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Tbio
HOXD4
Homeobox protein Hox-D4

Protein Summary
Description
Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. This gene belongs to the homeobox family of genes. The homeobox genes encode a highly conserved family of transcription factors that play an important role in morphogenesis in all multicellular organisms. Mammals possess four similar homeobox gene clusters, HOXA, HOXB, HOXC and HOXD, located on different chromosomes, consisting of 9 to 11 genes arranged in tandem. This gene is one of several homeobox HOXD genes located at 2q31-2q37 chromosome regions. Deletions that removed the entire HOXD gene cluster or 5' end of this cluster have been associated with severe limb and genital abnormalities. The protein encoded by this gene may play a role in determining positional values in developing limb buds. Alternatively spliced variants have been described but their full length nature has not been determined. [provided b ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000306324
  • ENSP00000302548
  • ENSG00000170166

Symbol
  • HOX4B
  • HOX4
  • HOX4B
  • HHO.C13
  • HOX-5.1
  • Hox-4.2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
co-expressed gene
1
gene perturbation
0.91
protein domain
0.85
tissue sample
0.69
kinase perturbation
0.6


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 57.26   (req: < 5)
Gene RIFs: 5   (req: <= 3)
Antibodies: 181   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 57.26   (req: >= 5)
Gene RIFs: 5   (req: > 3)
Antibodies: 181   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (90)
ANKHD1
Tbio
Novelty:  0.05390096
p_int:  0.987711374
p_ni:  0.012288619
p_wrong:  7e-9
Score:  0.194
Data Source:  BioPlex,STRINGDB
ACTBL2
Tbio
Novelty:  0.18080702
p_int:  0.907293063
p_ni:  0.092706937
Data Source:  BioPlex
ANKRD17
Tbio
Novelty:  0.03177323
p_int:  0.800039839
p_ni:  0.199960161
Score:  0.247
Data Source:  BioPlex,STRINGDB
HOXC6
Tbio
Family:  TF
Novelty:  0.00991192
Score:  0.97
Data Source:  STRINGDB
HOXC5
Tbio
Family:  TF
Novelty:  0.05354226
Score:  0.968
Data Source:  STRINGDB
HOXB5
Tbio
Family:  TF
Novelty:  0.01119871
Score:  0.968
Data Source:  STRINGDB
HOXA7
Tbio
Family:  TF
Novelty:  0.00337527
Score:  0.968
Data Source:  STRINGDB
HOXB6
Tbio
Family:  TF
Novelty:  0.0176813
Score:  0.967
Data Source:  STRINGDB
HOXA5
Tbio
Family:  TF
Novelty:  0.0058504
Score:  0.966
Data Source:  STRINGDB
HOXB7
Tbio
Family:  TF
Novelty:  0.00765378
Score:  0.966
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (3)
Activation of HOX genes during differentiation (R-HSA-5619507)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Activation of HOX genes during differentiation
Reactome
Activation of anterior HOX genes in hindbrain development during early embryogenesis
Reactome
Developmental Biology
Name
Explore in Pharos
Explore in Source
Activation of HOX genes during differentiation
Activation of anterior HOX genes in hindbrain development during early embryogenesis
Developmental Biology
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (12)
Find Similar Targets
Items per page:
10
1 – 4 of 4
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
NTNU_SB
Inferred from Mutant Phenotype (IMP)
NTNU_SB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Sequence Alignment (ISA)
NTNU_SB
Disease Associations (null)
No disease associations found
GWAS Traits (25)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
glomerular filtration rate
6
4
7
7.7
93.3
creatinine measurement
3
3
4
92.9
balding measurement
1
3
3
92.9
urate measurement
3
3
4
85.7
hematocrit
3
1
3
82.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
glomerular filtration rate
7
7.7
93.3
creatinine measurement
4
92.9
balding measurement
3
92.9
urate measurement
4
85.7
hematocrit
3
82.3
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Mouse
MGI:96208
15436
Rat
RGD:1309690
288153
Dog
homeobox D4 [Source:HGNC Symbol;Acc:HGNC:5138]
Cow
homeobox D4
513306
Pig
homeobox D4 [Source:HGNC Symbol;Acc:HGNC:5138]
Species
Name
OMA
EggNOG
Inparanoid
Mouse
Rat
Dog
homeobox D4 [Source:HGNC Symbol;Acc:HGNC:5138]
Cow
homeobox D4
Pig
homeobox D4 [Source:HGNC Symbol;Acc:HGNC:5138]
Publication Statistics
PubMed Score 57.26
PubMed score by year
PubTator Score 24.28
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title