Tchem CD63 CD63 antigen

Protein Summary

Description

Functions as cell surface receptor for TIMP1 and plays a role in the activation of cellular signaling cascades. Plays a role in the activation of ITGB1 and integrin signaling, leading to the activation of AKT, FAK/PTK2 and MAP kinases. Promotes cell survival, reorganization of the actin cytoskeleton, cell adhesion, spreading and migration, via its role in the activation of AKT and FAK/PTK2. Plays a role in VEGFA signaling via its role in regulating the internalization of KDR/VEGFR2. Plays a role in intracellular vesicular transport processes, and is required for normal trafficking of the PMEL luminal domain that is essential for the development and maturation of melanocytes. Plays a role in the adhesion of leukocytes onto endothelial cells via its role in the regulation of SELP trafficking. May play a role in mast cell degranulation in response to Ms4a2/FceRI stimulation, but not in mast cell degranulation in response to other stimuli. The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. The encoded protein is a cell surface glycoprotein that is known to complex with integrins. It may function as a blood platelet activation marker. Deficiency of this protein is associated with Hermansky-Pudlak syndrome. Also this gene has been associated with tumor progression. Alternative splicing results in multiple transcript variants encoding different protein isoforms. [provided by RefSeq, Apr 2012]

Uniprot Accession IDs

• P08962
• F8VZE2
• Q5TZP3
• Q8N6Z9
• Q9UCG6

Gene Name

• CD63

Ensembl ID

• ENST00000257857
• ENSP00000257857
• ENSG00000135404
• ENST00000420846
• ENSP00000393502
• ENST00000546939
• ENSP00000447356
• ENST00000549117
• ENSP00000447730
• ENST00000550776
• ENSP00000448091
• ENST00000552692
• ENSP00000449337
• ENST00000552754
• ENSP00000446807

Symbol

• MLA1
• TSPAN30
• MLA1
• ME491
• LAMP-3
• OMA81H
• TSPAN30

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
disease perturbation	1
kinase perturbation	0.95
PubMedID	0.86
disease	0.85
transcription factor binding site profile	0.76

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1861.74   (req: < 5)

Gene RIFs: 69   (req: <= 3)

Antibodies: 1768   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1861.74   (req: >= 5)

Gene RIFs: 69   (req: > 3)

Antibodies: 1768   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 14

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 11

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Expression Data (0 Tissues)

tutorial

No expression data found

Protein Sequence and Structure

Residue Counts

Protein Sequence

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Related Tools (4)

Target Illumination GWAS Analytics (TIGA)

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

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GENEVA

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

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GlyGen

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

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ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

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Approved Drugs (0)

No approved drugs found

Active Ligands (11)

Explore Active Ligands

1 – 10 of 11

lanraplenib

CD63Tchem

pIC50 : 8.21

US9290505, Ex.-1

CD63Tchem

pIC50 : 8.21

US9290505, Ex.-7

CD63Tchem

pIC50 : 8.06

US9290505, Ex.-5

CD63Tchem

pIC50 : 7.91

US9290505, Ex.-3

CD63Tchem

pIC50 : 7.88

US9290505, Ex.-6

CD63Tchem

pIC50 : 7.84

CHEMBL3952825

CD63Tchem

pIC50 : 7.8

CHEMBL3978560

CD63Tchem

pIC50 : 7

US9290505, Ex.-4

CD63Tchem

pIC50 : 6.8

CHEMBL3962740

CD63Tchem

pIC50 : 6.13

Protein-Protein Interactions (216)

Explore Interacting Targets

1 – 10 of 216

• See Interactions on String-DB

RETREG3

Tdark

Novelty:  0.99215801

p_int:  0.999358995

p_ni:  0.000583267

p_wrong:  0.000057738

Score:  0.185

Data Source:  BioPlex,STRINGDB

LGALS9

Tchem

Novelty:  0.00381766

p_int:  0.985084815

p_ni:  0.014165752

p_wrong:  0.000749432

Score:  0.422

Data Source:  BioPlex,STRINGDB

LGALS8

Tchem

Novelty:  0.00623836

p_int:  0.968415256

p_ni:  0.030446582

p_wrong:  0.001138162

Score:  0.182

Data Source:  BioPlex,STRINGDB

TSPAN2

Tbio

Novelty:  0.03842973

p_int:  0.957540493

p_ni:  0.041369199

p_wrong:  0.001090308

Score:  0.816

Data Source:  BioPlex,STRINGDB

LGALS3

Tchem

Novelty:  0.00032754

p_int:  0.943680806

p_ni:  0.055991896

p_wrong:  0.000327298

Score:  0.508

Data Source:  BioPlex,STRINGDB

TMEM47

Tdark

Novelty:  0.1571161

p_int:  0.936343015

p_ni:  0.063656975

p_wrong:  1.1e-8

Data Source:  BioPlex

TMEM208

Tdark

Novelty:  0.63059333

p_int:  0.935744792

p_ni:  0.064139369

p_wrong:  0.000115839

Data Source:  BioPlex

TSPAN31

Tbio

Novelty:  0.13580467

p_int:  0.911198547

p_ni:  0.088780038

p_wrong:  0.000021414

Score:  0.494

Data Source:  BioPlex,STRINGDB

SLC7A14

Tbio

Family:  Transporter

Novelty:  0.1613451

p_int:  0.882588032

p_ni:  0.117328615

p_wrong:  0.000083353

Data Source:  BioPlex

FAM241A

Tdark

Novelty:  1.04041354

p_int:  0.877948542

p_ni:  0.12198723

p_wrong:  0.000064228

Data Source:  BioPlex

Nearest Tclin Targets

Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.

Pathways (19)

Reactome (7)

KEGG (2)

WikiPathways (10)

Hemostasis (R-HSA-109582)

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Data Source	Name	Explore in Pharos	Explore in Source
Reactome	Hemostasis	666 targets	R-HSA-109582
Reactome	Immune System	2246 targets	R-HSA-168256
Reactome	Innate Immune System	1188 targets	R-HSA-168249
Reactome	Neutrophil degranulation	543 targets	R-HSA-6798695
Reactome	Platelet activation, signaling and aggregation	258 targets	R-HSA-76002

Name	Explore in Pharos	Explore in Source
Hemostasis	666 targets	R-HSA-109582
Immune System	2246 targets	R-HSA-168256
Innate Immune System	1188 targets	R-HSA-168249
Neutrophil degranulation	543 targets	R-HSA-6798695
Platelet activation, signaling and aggregation	258 targets	R-HSA-76002

Viral Interactions (0)

No viral interactions found

Gene Ontology Terms (29)

Components (15)

Processes (14)

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10

1 – 10 of 15

GO Term	Evidence	Assigned by
cell surface	Inferred from Direct Assay (IDA)	MGI
endosome lumen	Inferred from Direct Assay (IDA)	UniProtKB
endosome membrane	Inferred from Direct Assay (IDA)	UniProtKB
extracellular exosome	Inferred from Direct Assay (IDA)	UniProtKB
extracellular space	Inferred from Direct Assay (IDA)	UniProtKB
intrinsic component of plasma membrane	Inferred from Direct Assay (IDA)	UniProtKB
late endosome membrane	Inferred from Direct Assay (IDA)	UniProtKB
lysosomal membrane	Inferred from Direct Assay (IDA)	UniProtKB
multivesicular body membrane	Inferred from Direct Assay (IDA)	UniProtKB
multivesicular body, internal vesicle	Inferred from Direct Assay (IDA)	UniProtKB

Disease Associations (null)

No disease associations found

GWAS Traits (11)

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5

1 – 5 of 11

GWAS Trait	EFO ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
refractive error	MONDO_0004892	3	3	3	13.8	98.1
Myopia	HP_0000545	3	2	0	1.3	95.9
age at onset	EFO_0004847	1	1	0	13.8	87.2
Abnormality of refraction	HP_0000539	1	1	1		75.9
atrophic macular degeneration	EFO_1001492	1	1	0	1.2	50.9

• Explore on Target Illumination GWAS Analytics (TIGA)

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5

1 – 5 of 11

GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
refractive error	MONDO_0004892	3	13.8	98.1
Myopia	HP_0000545	0	1.3	95.9
age at onset	EFO_0004847	0	13.8	87.2
Abnormality of refraction	HP_0000539	1		75.9
atrophic macular degeneration	EFO_1001492	0	1.2	50.9

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Find similar targets by:

UniProt Keyword Find Similar Targets

No Header	No Header
Alternative splicing
Cell membrane
Complete proteome
Direct protein sequencing
Endosome
Glycoprotein
Lipoprotein
Lysosome
Membrane
Palmitate

GWAS Trait Find Similar Targets

No Header	No Header
Abnormality of refraction
age at onset
age-related macular degeneration
atrial fibrillation
atrophic macular degeneration
educational attainment
heart rate
Myopia
refractive error
response to beta blocker

MGI Phenotype Find Similar Targets

No Header	No Header
behavior/neurological phenotype
digestive/alimentary phenotype
homeostasis/metabolism phenotype
renal/urinary system phenotype

IDG Resources

No IDG generated resources found

Orthologs (11)

1 – 5 of 11

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Chimp	CD63 molecule	VGNC:12886	451969
Macaque	CD63 molecule		709828
Mouse	CD63 antigen	MGI:99529	12512
Rat	Cd63 molecule	RGD:62080	29186
Dog	CD63 molecule	VGNC:38967	474391

Species	Name	OMA	EggNOG	Inparanoid
Chimp	CD63 molecule
Macaque	CD63 molecule
Mouse	CD63 antigen
Rat	Cd63 molecule
Dog	CD63 molecule

Publication Statistics

PubMed Score 1861.74

PubMed score by year

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PubTator Score 707.36

PubTator score by year

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Related Publications

Text Mined References (127)

GeneRif Annotations (69)

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PMID	Year	Title