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Tchem
CD63
CD63 antigen

Protein Summary
Description
Functions as cell surface receptor for TIMP1 and plays a role in the activation of cellular signaling cascades. Plays a role in the activation of ITGB1 and integrin signaling, leading to the activation of AKT, FAK/PTK2 and MAP kinases. Promotes cell survival, reorganization of the actin cytoskeleton, cell adhesion, spreading and migration, via its role in the activation of AKT and FAK/PTK2. Plays a role in VEGFA signaling via its role in regulating the internalization of KDR/VEGFR2. Plays a role in intracellular vesicular transport processes, and is required for normal trafficking of the PMEL luminal domain that is essential for the development and maturation of melanocytes. Plays a role in the adhesion of leukocytes onto endothelial cells via its role in the regulation of SELP trafficking. May play a role in mast cell degranulation in response to Ms4a2/FceRI stimulation, but not in mast cell degranulation in response to other stimuli. The protein encoded by this gene is a member of th ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000257857
  • ENSP00000257857
  • ENSG00000135404
  • ENST00000420846
  • ENSP00000393502
  • ENST00000546939
  • ENSP00000447356
  • ENST00000549117
  • ENSP00000447730
  • ENST00000550776
  • ENSP00000448091
  • ENST00000552692
  • ENSP00000449337
  • ENST00000552754
  • ENSP00000446807

Symbol
  • MLA1
  • TSPAN30
  • MLA1
  • ME491
  • LAMP-3
  • OMA81H
  • TSPAN30
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
1
kinase perturbation
0.95
PubMedID
0.86
disease
0.85
transcription factor binding site profile
0.76


Related Tools
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1368.04   (req: < 5)
Gene RIFs: 69   (req: <= 3)
Antibodies: 1768   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1368.04   (req: >= 5)
Gene RIFs: 69   (req: > 3)
Antibodies: 1768   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 14
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 11
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
CD63 molecule
VGNC:12886
451969
Macaque
CD63 molecule
709828
Mouse
MGI:99529
12512
Rat
RGD:62080
29186
Dog
CD63 molecule
VGNC:38967
474391
Species
Name
OMA
EggNOG
Inparanoid
Chimp
CD63 molecule
Macaque
CD63 molecule
Mouse
Rat
Dog
CD63 molecule
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-P08962-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (19)
Hemostasis (R-HSA-109582)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 7
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Hemostasis
Reactome
Immune System
Reactome
Innate Immune System
Reactome
Neutrophil degranulation
Reactome
Platelet activation, signaling and aggregation
Name
Explore in Pharos
Explore in Source
Hemostasis
Immune System
Innate Immune System
Neutrophil degranulation
Platelet activation, signaling and aggregation
Gene Ontology Terms (29)
Items per page:
10
1 – 10 of 15
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
MGI
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Protein-Protein Interactions (216)
1 – 10 of 216
RETREG3
Tdark
Novelty: 0.99215801
p_int: 0.999358995
p_ni: 0.000583267
p_wrong: 0.000057738
Score: 0.185
Data Source: BioPlex,STRINGDB
LGALS9
Tchem
Novelty: 0.00381766
p_int: 0.985084815
p_ni: 0.014165752
p_wrong: 0.000749432
Score: 0.422
Data Source: BioPlex,STRINGDB
LGALS8
Tchem
Novelty: 0.00623836
p_int: 0.968415256
p_ni: 0.030446582
p_wrong: 0.001138162
Score: 0.182
Data Source: BioPlex,STRINGDB
TSPAN2
Tbio
Novelty: 0.03842973
p_int: 0.957540493
p_ni: 0.041369199
p_wrong: 0.001090308
Score: 0.816
Data Source: BioPlex,STRINGDB
LGALS3
Tchem
Novelty: 0.00032754
p_int: 0.943680806
p_ni: 0.055991896
p_wrong: 0.000327298
Score: 0.508
Data Source: BioPlex,STRINGDB
TMEM47
Tdark
Novelty: 0.1571161
p_int: 0.936343015
p_ni: 0.063656975
p_wrong: 1.1e-8
Data Source: BioPlex
TMEM208
Tdark
Novelty: 0.63059333
p_int: 0.935744792
p_ni: 0.064139369
p_wrong: 0.000115839
Data Source: BioPlex
TSPAN31
Tbio
Novelty: 0.13580467
p_int: 0.911198547
p_ni: 0.088780038
p_wrong: 0.000021414
Score: 0.494
Data Source: BioPlex,STRINGDB
SLC7A14
Tbio
Family: Transporter
Novelty: 0.1613451
p_int: 0.882588032
p_ni: 0.117328615
p_wrong: 0.000083353
Data Source: BioPlex
FAM241A
Tdark
Novelty: 1.04041354
p_int: 0.877948542
p_ni: 0.12198723
p_wrong: 0.000064228
Data Source: BioPlex
Publication Statistics
PubMed Score  1368.04

PubMed score by year
PubTator Score  707.36

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer