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Tbio
NMB
Neuromedin-B

Protein Summary
Description
Stimulates smooth muscle contraction in a manner similar to that of bombesin. This gene encodes a member of the bombesin-like family of neuropeptides, which negatively regulate eating behavior. The encoded protein may regulate colonic smooth muscle contraction through binding to its cognate receptor, the neuromedin B receptor (NMBR). Polymorphisms of this gene may be associated with hunger, weight gain and obesity. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2015]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000360476
  • ENSP00000353664
  • ENSG00000197696
  • ENST00000394588
  • ENSP00000378089
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
0.76
gene perturbation
0.66
histone modification site profile
0.66
biological process
0.62
tissue sample
0.62


Protein Classes
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 130.27   (req: < 5)
Gene RIFs: 12   (req: <= 3)
Antibodies: 142   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 130.27   (req: >= 5)
Gene RIFs: 12   (req: > 3)
Antibodies: 142   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 12
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (194)
UBAC1
Tbio
Novelty:  0.00122518
p_int:  0.99996942
p_ni:  0.00003058
Data Source:  BioPlex
NIPBL
Tbio
Novelty:  0.00462654
p_int:  0.999894293
p_ni:  0.000055671
p_wrong:  0.000050036
Data Source:  BioPlex
MAU2
Tdark
Novelty:  0.00594861
p_int:  0.999806182
p_ni:  0.000079992
p_wrong:  0.000113826
Data Source:  BioPlex
RNF123
Tbio
Family:  Enzyme
Novelty:  0.01872044
p_int:  0.999196716
p_ni:  0.000803284
Data Source:  BioPlex
ZMYND19
Tdark
Novelty:  0.3590069
p_int:  0.983619509
p_ni:  0.016380379
p_wrong:  1.13e-7
Data Source:  BioPlex
RMND5A
Tbio
Novelty:  0.01820349
p_int:  0.951595444
p_ni:  0.048404556
Data Source:  BioPlex
WDR26
Tbio
Novelty:  0.04140166
p_int:  0.942705089
p_ni:  0.057294911
Data Source:  BioPlex
GID8
Tbio
Novelty:  0.21243963
p_int:  0.929395808
p_ni:  0.070604192
Data Source:  BioPlex
MAEA
Tbio
Novelty:  0.00833813
p_int:  0.917110729
p_ni:  0.082889271
Data Source:  BioPlex
XRCC2
Tbio
Novelty:  0.00862049
p_int:  0.893774048
p_ni:  0.000139599
p_wrong:  0.106086353
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (8)
Class A/1 (Rhodopsin-like receptors) (R-HSA-373076)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 7
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Class A/1 (Rhodopsin-like receptors)
Reactome
G alpha (q) signalling events
Reactome
GPCR downstream signalling
Reactome
GPCR ligand binding
Reactome
Peptide ligand-binding receptors
Name
Explore in Pharos
Explore in Source
Class A/1 (Rhodopsin-like receptors)
G alpha (q) signalling events
GPCR downstream signalling
GPCR ligand binding
Peptide ligand-binding receptors
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (12)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
schizophrenia
5
4
1
1.1
90.1
BMI-adjusted hip circumference
2
5
5
75.9
transmembrane glycoprotein NMB measurement
1
1
1
66.5
glomerular filtration rate
3
1
3
61
1
1
0
1.1
56.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
schizophrenia
1
1.1
90.1
BMI-adjusted hip circumference
5
75.9
transmembrane glycoprotein NMB measurement
1
66.5
glomerular filtration rate
3
61
0
1.1
56.3
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (7)
1 – 5 of 7
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
neuromedin B
VGNC:1908
743470
Mouse
MGI:1915289
68039
Rat
RGD:1562710
499194
Dog
neuromedin B
VGNC:43854
479051
Horse
neuromedin B
VGNC:20772
100053292
Species
Name
OMA
EggNOG
Inparanoid
Chimp
neuromedin B
Mouse
Rat
Dog
neuromedin B
Horse
neuromedin B
Publication Statistics
PubMed Score 130.27
PubMed score by year
PubTator Score 138.04
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title