Tbio NMB Neuromedin-B

Protein Summary

Description

Stimulates smooth muscle contraction in a manner similar to that of bombesin. This gene encodes a member of the bombesin-like family of neuropeptides, which negatively regulate eating behavior. The encoded protein may regulate colonic smooth muscle contraction through binding to its cognate receptor, the neuromedin B receptor (NMBR). Polymorphisms of this gene may be associated with hunger, weight gain and obesity. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2015]

Uniprot Accession IDs

• P08949
• Q96A06
• Q96HH5

Gene Name

• NMB

Ensembl ID

• ENST00000360476
• ENSP00000353664
• ENSG00000197696
• ENST00000394588
• ENSP00000378089

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
kinase perturbation	0.76
gene perturbation	0.66
histone modification site profile	0.66
biological process	0.62
tissue sample	0.62

Protein Classes

DTO Classes

Neuromedin-b Receptor

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 130.27   (req: < 5)

Gene RIFs: 13   (req: <= 3)

Antibodies: 142   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 130.27   (req: >= 5)

Gene RIFs: 13   (req: > 3)

Antibodies: 142   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 12

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0