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Tclin
CHRM5
Muscarinic acetylcholine receptor M5

Protein Summary
Description
The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. Primary transducing effect is Pi turnover. The muscarinic cholinergic receptors belong to a larger family of G protein-coupled receptors. The functional diversity of these receptors is defined by the binding of acetylcholine and includes cellular responses such as adenylate cyclase inhibition, phosphoinositide degeneration, and potassium channel mediation. Muscarinic receptors influence many effects of acetylcholine in the central and peripheral nervous system. The clinical implications of this receptor are unknown; however, stimulation of this receptor is known to increase cyclic AMP levels. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000383263
  • ENSP00000372750
  • ENSG00000184984
  • ENST00000557872
  • ENSP00000453745

Symbol
  • HM5
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
drug
0.99
ligand (chemical)
0.96
biological process
0.75
molecular function
0.7
trait
0.61


Related Tools
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 38.42   (req: < 5)
Gene RIFs: 10   (req: <= 3)
Antibodies: 218   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 38.42   (req: >= 5)
Gene RIFs: 10   (req: > 3)
Antibodies: 218   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 15
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 124
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 38
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
cholinergic receptor muscarinic 5
VGNC:10166
503515
Macaque
cholinergic receptor muscarinic 5
574330
Mouse
MGI:109248
213788
Rat
RGD:620027
53949
Dog
cholinergic receptor muscarinic 5
VGNC:39235
487472
Species
Name
OMA
EggNOG
Inparanoid
Chimp
cholinergic receptor muscarinic 5
Macaque
cholinergic receptor muscarinic 5
Mouse
Rat
Dog
cholinergic receptor muscarinic 5
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-P08912-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (19)
Amine ligand-binding receptors (R-HSA-375280)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 8
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Amine ligand-binding receptors
Reactome
Class A/1 (Rhodopsin-like receptors)
Reactome
G alpha (q) signalling events
Reactome
GPCR downstream signalling
Reactome
GPCR ligand binding
Name
Explore in Pharos
Explore in Source
Amine ligand-binding receptors
Class A/1 (Rhodopsin-like receptors)
G alpha (q) signalling events
GPCR downstream signalling
GPCR ligand binding
Gene Ontology Terms (20)
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Traceable Author Statement (TAS)
ProtInc
Protein-Protein Interactions (181)
1 – 10 of 181
GRM5
Tchem
Family: GPCR
Novelty: 0.00062552
Score: 0.945
Data Source: STRINGDB
GRK2
Tchem
Family: Kinase
Novelty: 0.00200696
Score: 0.942
Data Source: STRINGDB
CCK
Tbio
Novelty: 0.00012268
Score: 0.92
Data Source: STRINGDB
CASR
Tclin
Family: GPCR
Novelty: 0.00061316
Score: 0.919
Data Source: STRINGDB
GNAQ
Tbio
Novelty: 0.0008997
Score: 0.919
Data Source: STRINGDB
GNA11
Tbio
Novelty: 0.00128664
Score: 0.918
Data Source: STRINGDB
GNB5
Tbio
Novelty: 0.0067714
Score: 0.918
Data Source: STRINGDB
GNG13
Tbio
Novelty: 0.13011919
Score: 0.916
Data Source: STRINGDB
BDKRB2
Tclin
Family: GPCR
Novelty: 0.00335227
Score: 0.915
Data Source: STRINGDB
ADRA1D
Tclin
Family: GPCR
Novelty: 0.00203304
Score: 0.915
Data Source: STRINGDB
Publication Statistics
PubMed Score  38.42

PubMed score by year
PubTator Score  7.48

PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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