Tclin IL6R Interleukin-6 receptor subunit alpha

Protein Summary

Description

Part of the receptor for interleukin 6. Binds to IL6 with low affinity, but does not transduce a signal. Signal activation necessitate an association with IL6ST. Activation may lead to the regulation of the immune response, acute-phase reactions and hematopoiesis. Low concentration of a soluble form of IL6 receptor acts as an agonist of IL6 activity. This gene encodes a subunit of the interleukin 6 (IL6) receptor complex. Interleukin 6 is a potent pleiotropic cytokine that regulates cell growth and differentiation and plays an important role in the immune response. The IL6 receptor is a protein complex consisting of this protein and interleukin 6 signal transducer (IL6ST/GP130/IL6-beta), a receptor subunit also shared by many other cytokines. Dysregulated production of IL6 and this receptor are implicated in the pathogenesis of many diseases, such as multiple myeloma, autoimmune diseases and prostate cancer. Alternatively spliced transcript variants encoding distinct isoforms have been reported. A pseudogene of this gene is found on chromosome 9.[provided by RefSeq, May 2011]

Uniprot Accession IDs

• P08887
• A8KAE8
• B2R6V4
• Q16202
• Q53EQ7
• Q5FWG2
• Q5VZ23
• IL-6 receptor subunit alpha

Gene Name

• IL6R

Ensembl ID

• ENST00000344086
• ENSP00000340589
• ENSG00000160712
• ENST00000368485
• ENSP00000357470

Symbol

• IL6Q
• gp80
• CD126
• IL6RA
• IL6RQ
• IL-6RA
• IL-6R-1

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
biological term	0.99
trait	0.93
PubMedID	0.92
transcription factor binding site profile	0.92
biological process	0.89

Protein Classes

PANTHER Classes

Protein / Signaling Molecule / Cytokine / Interleukin-6 Receptor Subunit Alpha

Protein / Defense/immunity Protein / Interleukin-6 Receptor Subunit Alpha

DTO Classes

Protein / Signaling / Cytokine / Interleukin-6 Receptor Subunit Alpha

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 522.07   (req: < 5)

Gene RIFs: 390   (req: <= 3)

Antibodies: 896   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 522.07   (req: >= 5)

Gene RIFs: 390   (req: > 3)

Antibodies: 896   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 41

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 3