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Tbio
RPSA
40S ribosomal protein SA

Protein Summary
Description
Required for the assembly and/or stability of the 40S ribosomal subunit. Required for the processing of the 20S rRNA-precursor to mature 18S rRNA in a late step of the maturation of 40S ribosomal subunits. Also functions as a cell surface receptor for laminin. Plays a role in cell adhesion to the basement membrane and in the consequent activation of signaling transduction pathways. May play a role in cell fate determination and tissue morphogenesis. Acts as a PPP1R16B-dependent substrate of PPP1CA. (Microbial infection) Acts as a receptor for the Adeno-associated viruses 2,3,8 and 9. (Microbial infection) Acts as a receptor for the Dengue virus. (Microbial infection) Acts as a receptor for the Sindbis virus. (Microbial infection) Acts as a receptor for the Venezuelan equine encephalitis virus. (Microbial infection) Acts as a receptor for the pathogenic prion protein. (Microbial infection) Acts as a receptor for bacteria. Laminins, a family of extracellular matrix glycoproteins, are the ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000301821
  • ENSP00000346067
  • ENSG00000168028

Symbol
  • LAMBR
  • LAMR1
  • SA
  • LBP
  • LRP
  • p40
  • 67LR
  • ICAS
  • lamR
  • 37LRP
  • LAMBR
  • LAMR1
  • LRP/LR
  • LBP/p40
  • NEM/1CHD4
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
interacting protein
1
disease perturbation
0.87
biological process
0.86
protein domain
0.85
disease
0.83


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 498.46   (req: < 5)
Gene RIFs: 78   (req: <= 3)
Antibodies: 350   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 498.46   (req: >= 5)
Gene RIFs: 78   (req: > 3)
Antibodies: 350   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 15
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0