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Tbio
RPSA
40S ribosomal protein SA

Protein Summary
Description
Required for the assembly and/or stability of the 40S ribosomal subunit. Required for the processing of the 20S rRNA-precursor to mature 18S rRNA in a late step of the maturation of 40S ribosomal subunits. Also functions as a cell surface receptor for laminin. Plays a role in cell adhesion to the basement membrane and in the consequent activation of signaling transduction pathways. May play a role in cell fate determination and tissue morphogenesis. Acts as a PPP1R16B-dependent substrate of PPP1CA. (Microbial infection) Acts as a receptor for the Adeno-associated viruses 2,3,8 and 9. (Microbial infection) Acts as a receptor for the Dengue virus. (Microbial infection) Acts as a receptor for the Sindbis virus. (Microbial infection) Acts as a receptor for the Venezuelan equine encephalitis virus. (Microbial infection) Acts as a receptor for the pathogenic prion protein. (Microbial infection) Acts as a receptor for bacteria. Laminins, a family of extracellular matrix glycoproteins, are the ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000301821
  • ENSP00000346067
  • ENSG00000168028

Symbol
  • LAMBR
  • LAMR1
  • SA
  • LBP
  • LRP
  • p40
  • 67LR
  • ICAS
  • lamR
  • 37LRP
  • LAMBR
  • LAMR1
  • LRP/LR
  • LBP/p40
  • NEM/1CHD4
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
interacting protein
1
disease perturbation
0.87
biological process
0.86
protein domain
0.85
disease
0.83


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 440.48   (req: < 5)
Gene RIFs: 78   (req: <= 3)
Antibodies: 350   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 440.48   (req: >= 5)
Gene RIFs: 78   (req: > 3)
Antibodies: 350   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 15
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (577)
CDR2L
Tbio
Novelty:  0.09295886
p_int:  0.999994801
p_ni:  0.000005199
Score:  0.719
Data Source:  BioPlex,STRINGDB
RPS27A
Tbio
Novelty:  0.00658124
p_int:  0.999163983
p_ni:  0.000836007
p_wrong:  1e-8
Score:  0.999
Data Source:  BioPlex,STRINGDB
CDR2
Tbio
Novelty:  0.00141419
p_int:  0.996767146
p_ni:  0.003232854
Score:  0.163
Data Source:  BioPlex,STRINGDB
ZNF335
Tbio
Family:  TF
Novelty:  0.05115842
p_int:  0.995779224
p_ni:  0.001865867
p_wrong:  0.002354909
Score:  0.309
Data Source:  BioPlex,STRINGDB
ZNF358
Tdark
Family:  TF
Novelty:  0.77495044
p_int:  0.995388152
p_ni:  0.004594798
p_wrong:  0.00001705
Score:  0.193
Data Source:  BioPlex,STRINGDB
DHX57
Tdark
Family:  Enzyme
Novelty:  0.8244078
p_int:  0.995246671
p_ni:  0.004753329
Score:  0.653
Data Source:  BioPlex,STRINGDB
HIST1H1A
Tbio
Novelty:  0.00123818
p_int:  0.989161424
p_ni:  0.010838576
Score:  0.22
Data Source:  BioPlex,STRINGDB
RPS21
Tbio
Novelty:  0.00578555
p_int:  0.988959674
p_ni:  0.011040326
Score:  0.999
Data Source:  BioPlex,STRINGDB
BMS1
Tbio
Novelty:  0.0349992
p_int:  0.983576171
p_ni:  0.016423819
p_wrong:  1e-8
Score:  0.922
Data Source:  BioPlex,STRINGDB
RPL26L1
Tdark
Novelty:  0.75408617
p_int:  0.983534105
p_ni:  0.016465895
Score:  0.995
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (39)
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S (R-HSA-72662)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 36
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S
Reactome
Axon guidance
Reactome
Cap-dependent Translation Initiation
Reactome
Developmental Biology
Reactome
Disease
Name
Explore in Pharos
Explore in Source
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S
Axon guidance
Cap-dependent Translation Initiation
Developmental Biology
Disease
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (23)
Find Similar Targets
Items per page:
10
1 – 6 of 6
GO Term
Evidence
Assigned by
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from High Throughput Direct Assay (HDA)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Electronic Annotation (IEA)
UniProtKB-UniRule
Inferred from Electronic Annotation (IEA)
UniProtKB-UniRule
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Disease Associations ()
No disease associations found
GWAS Traits (7)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
1
1
0
1.4
67.9
1
1
0
1.1
39.6
sporadic amyotrophic lateral sclerosis
1
1
1
21.5
cortical thickness
1
1
1
12.9
Thyroid preparation use measurement
1
1
1
9.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
1.4
67.9
0
1.1
39.6
sporadic amyotrophic lateral sclerosis
1
21.5
cortical thickness
1
12.9
Thyroid preparation use measurement
1
9.1
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
ribosomal protein SA
693293
Mouse
MGI:105381
16785
Rat
RGD:71026
29236
Dog
ribosomal protein SA
477029
Horse
ribosomal protein SA
100055367
Species
Name
OMA
EggNOG
Inparanoid
Macaque
ribosomal protein SA
Mouse
Rat
Dog
ribosomal protein SA
Horse
ribosomal protein SA
Publication Statistics
PubMed Score 440.48
PubMed score by year
PubTator Score 196.16
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title