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Tchem
STS
Steryl-sulfatase

Protein Classes
Protein Summary
Description
Conversion of sulfated steroid precursors to estrogens during pregnancy. This gene encodes a multi-pass membrane protein that is localized to the endoplasmic reticulum. It belongs to the sulfatase family and hydrolyzes several 3-beta-hydroxysteroid sulfates, which serve as metabolic precursors for estrogens, androgens, and cholesterol. Mutations in this gene are associated with X-linked ichthyosis (XLI). Alternatively spliced transcript variants resulting from the use of different promoters have been described for this gene (PMID:17601726). [provided by RefSeq, Mar 2016]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000217961
  • ENSP00000217961
  • ENSG00000101846

Symbol
  • ARSC1
  • ES
  • ASC
  • XLI
  • ARSC
  • SSDD
  • ARSC1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
0.88
chemical
0.86
cellular component
0.77
transcription factor perturbation
0.74
biological term
0.66


Related Tools
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 277.54   (req: < 5)
Gene RIFs: 70   (req: <= 3)
Antibodies: 245   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 277.54   (req: >= 5)
Gene RIFs: 70   (req: > 3)
Antibodies: 245   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 247
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
steroid sulfatase
VGNC:14719
465478
Macaque
steroid sulfatase
707799
Rat
RGD:3783
24800
Dog
steroid sulfatase
VGNC:54604
491727
Horse
steroid sulfatase
VGNC:49276
100034102
Species
Name
OMA
EggNOG
Inparanoid
Chimp
steroid sulfatase
Macaque
steroid sulfatase
Rat
Dog
steroid sulfatase
Horse
steroid sulfatase
Protein Structure (1 Structure, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P08842-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (11)
Gamma carboxylation, hypusine formation and arylsulfatase activation (R-HSA-163841)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 8
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Gamma carboxylation, hypusine formation and arylsulfatase activation
Reactome
Glycosphingolipid metabolism
Reactome
Metabolism
Reactome
Metabolism of lipids
Reactome
Metabolism of proteins
Name
Explore in Pharos
Explore in Source
Gamma carboxylation, hypusine formation and arylsulfatase activation
Glycosphingolipid metabolism
Metabolism
Metabolism of lipids
Metabolism of proteins
Protein-Protein Interactions (151)
1 – 10 of 151
RETREG2
Tdark
Novelty: 0.18851807
p_int: 0.999561034
p_ni: 0.000284243
p_wrong: 0.000154723
Score: 0.173
Data Source: BioPlex,STRINGDB
SUMF1
Tbio
Family: Enzyme
Novelty: 0.00954537
p_int: 0.99881003
p_ni: 0.001021465
p_wrong: 0.000168505
Score: 0.973
Data Source: BioPlex,STRINGDB
JAG2
Tbio
Novelty: 0.00176158
p_int: 0.997541032
p_ni: 0.00245894
p_wrong: 2.7e-8
Score: 0.179
Data Source: BioPlex,STRINGDB
TBC1D22B
Tbio
Novelty: 0.49852962
p_int: 0.99695425
p_ni: 0.003045352
p_wrong: 3.98e-7
Data Source: BioPlex
FUT8
Tbio
Family: Enzyme
Novelty: 0.00675388
p_int: 0.996595556
p_ni: 0.003403752
p_wrong: 6.92e-7
Data Source: BioPlex
LYZL1
Tbio
Family: Enzyme
Novelty: 0.10945096
p_int: 0.991114877
p_ni: 0.006779716
p_wrong: 0.002105407
Data Source: BioPlex
ALG9
Tbio
Family: Enzyme
Novelty: 0.02975572
p_int: 0.990421061
p_ni: 0.009578938
p_wrong: 1e-9
Score: 0.181
Data Source: BioPlex,STRINGDB
ZDHHC6
Tbio
Family: Enzyme
Novelty: 0.17384821
p_int: 0.984773737
p_ni: 0.01505259
p_wrong: 0.000173673
Data Source: BioPlex
SLC30A1
Tbio
Family: Transporter
Novelty: 0.00528427
p_int: 0.969888666
p_ni: 0.030106527
p_wrong: 0.000004807
Data Source: BioPlex
LRRC8A
Tbio
Novelty: 0.0163093
p_int: 0.950711772
p_ni: 0.049288204
p_wrong: 2.4e-8
Data Source: BioPlex
Publication Statistics
PubMed Score  277.54

PubMed score by year
PubTator Score  1502.31

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer