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Tchem
IGFBP1
Insulin-like growth factor-binding protein 1

Protein Classes
Protein Summary
Description
IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their cell surface receptors. Promotes cell migration. This gene is a member of the insulin-like growth factor binding protein (IGFBP) family and encodes a protein with an IGFBP N-terminal domain and a thyroglobulin type-I domain. The encoded protein, mainly expressed in the liver, circulates in the plasma and binds both insulin-like growth factors (IGFs) I and II, prolonging their half-lives and altering their interaction with cell surface receptors. This protein is important in cell migration and metabolism. Low levels of this protein may be associated with impaired glucose tolerance, vascular disease and hypertension in human patients. [provided by RefSeq, Aug 2017]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000275525
  • ENSP00000275525
  • ENSG00000146678

Symbol
  • IBP1
  • AFBP
  • IBP1
  • PP12
  • IGF-BP25
  • hIGFBP-1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.92
biological term
0.72
disease
0.69
virus perturbation
0.68
PubMedID
0.67


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1177.71   (req: < 5)
Gene RIFs: 209   (req: <= 3)
Antibodies: 600   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1177.71   (req: >= 5)
Gene RIFs: 209   (req: > 3)
Antibodies: 600   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 13
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 2
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Data Bank (3)
1 – 3 of 3
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (91)
ATF4 activates genes in response to endoplasmic reticulum stress (R-HSA-380994)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 12
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
ATF4 activates genes in response to endoplasmic reticulum stress
Reactome
FOXO-mediated transcription
Reactome
FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes
Reactome
Gene expression (Transcription)
Reactome
Generic Transcription Pathway
Name
Explore in Pharos
Explore in Source
ATF4 activates genes in response to endoplasmic reticulum stress
FOXO-mediated transcription
FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes
Gene expression (Transcription)
Generic Transcription Pathway
Protein-Protein Interactions (222)
1 – 10 of 222
PTPN3
Tbio
Family: Enzyme
Novelty: 0.03232859
p_int: 0.999994926
p_ni: 0.000004162
p_wrong: 9.12e-7
Score: 0.282
Data Source: BioPlex,STRINGDB
TRIP6
Tbio
Novelty: 0.03035413
p_int: 0.999994325
p_ni: 0.000005675
Data Source: BioPlex
SUSD5
Tdark
Novelty: 3
p_int: 0.999491741
p_ni: 0.000507674
p_wrong: 5.85e-7
Score: 0.177
Data Source: BioPlex,STRINGDB
ADAMTS1
Tchem
Family: Enzyme
Novelty: 0.00302564
p_int: 0.994809707
p_ni: 0.005190293
Score: 0.264
Data Source: BioPlex,STRINGDB
ZNF696
Tdark
Family: TF
Novelty: 11
p_int: 0.989424894
p_ni: 0.010575106
p_wrong: 1e-9
Data Source: BioPlex
TIMP1
Tbio
Family: Enzyme
Novelty: 0.00025759
p_int: 0.985022977
p_ni: 0.014728711
p_wrong: 0.000248313
Score: 0.95
Data Source: BioPlex,STRINGDB
IGF2
Tbio
Novelty: 0.00024884
p_int: 0.983864127
p_ni: 2.9e-7
p_wrong: 0.016135582
Score: 0.995
Data Source: BioPlex,Reactome,STRINGDB
PLXDC2
Tbio
Novelty: 0.11383622
p_int: 0.980055149
p_ni: 0.019944851
Data Source: BioPlex
GNB2
Tbio
Novelty: 0.20536996
p_int: 0.965513412
p_ni: 0.034486583
p_wrong: 5e-9
Data Source: BioPlex
ZNF664
Tdark
Family: TF
Novelty: 0.33511491
p_int: 0.947187987
p_ni: 0.000094004
p_wrong: 0.052718009
Score: 0.19
Data Source: BioPlex,STRINGDB
Publication Statistics
PubMed Score  1177.71

PubMed score by year
PubTator Score  1541.8

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer