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Tchem
IGFBP1
Insulin-like growth factor-binding protein 1

Protein Summary
Description
IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their cell surface receptors. Promotes cell migration. This gene is a member of the insulin-like growth factor binding protein (IGFBP) family and encodes a protein with an IGFBP N-terminal domain and a thyroglobulin type-I domain. The encoded protein, mainly expressed in the liver, circulates in the plasma and binds both insulin-like growth factors (IGFs) I and II, prolonging their half-lives and altering their interaction with cell surface receptors. This protein is important in cell migration and metabolism. Low levels of this protein may be associated with impaired glucose tolerance, vascular disease and hypertension in human patients. [provided by RefSeq, Aug 2017]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000275525
  • ENSP00000275525
  • ENSG00000146678

Symbol
  • IBP1
  • AFBP
  • IBP1
  • PP12
  • IGF-BP25
  • hIGFBP-1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.92
biological term
0.72
disease
0.69
virus perturbation
0.68
PubMedID
0.67


Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1392.57   (req: < 5)
Gene RIFs: 209   (req: <= 3)
Antibodies: 600   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1392.57   (req: >= 5)
Gene RIFs: 209   (req: > 3)
Antibodies: 600   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 13
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 2
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (11)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
pulse pressure measurement
4
3
4
89.9
IGF-1 measurement
1
3
3
87.7
appendicular lean mass
2
2
2
63.9
body height
1
1
1
62.8
heel bone mineral density
1
1
1
44.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
pulse pressure measurement
4
89.9
IGF-1 measurement
3
87.7
appendicular lean mass
2
63.9
body height
1
62.8
heel bone mineral density
1
44.2
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
insulin like growth factor binding protein 1
VGNC:4397
463395
Macaque
insulin like growth factor binding protein 1
696994
Mouse
MGI:96436
16006
Rat
RGD:2872
25685
Dog
insulin like growth factor binding protein 1
VGNC:41902
480812
Species
Name
OMA
EggNOG
Inparanoid
Chimp
insulin like growth factor binding protein 1
Macaque
insulin like growth factor binding protein 1
Mouse
Rat
Dog
insulin like growth factor binding protein 1
Protein Structure (3 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P08833-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 3 of 3
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (91)
ATF4 activates genes in response to endoplasmic reticulum stress (R-HSA-380994)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 12
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
ATF4 activates genes in response to endoplasmic reticulum stress
Reactome
FOXO-mediated transcription
Reactome
FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes
Reactome
Gene expression (Transcription)
Reactome
Generic Transcription Pathway
Name
Explore in Pharos
Explore in Source
ATF4 activates genes in response to endoplasmic reticulum stress
FOXO-mediated transcription
FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes
Gene expression (Transcription)
Generic Transcription Pathway
Protein-Protein Interactions (222)
1 – 10 of 222
PTPN3
Tbio
Family:  Enzyme
Novelty:  0.02390509
p_int:  0.999994926
p_ni:  0.000004162
p_wrong:  9.12e-7
Score:  0.282
Data Source:  BioPlex,STRINGDB
TRIP6
Tbio
Novelty:  0.02183202
p_int:  0.999994325
p_ni:  0.000005675
Data Source:  BioPlex
SUSD5
Tdark
Novelty:  1.0992718
p_int:  0.999491741
p_ni:  0.000507674
p_wrong:  5.85e-7
Score:  0.177
Data Source:  BioPlex,STRINGDB
ADAMTS1
Tchem
Family:  Enzyme
Novelty:  0.00483758
p_int:  0.994809707
p_ni:  0.005190293
Score:  0.264
Data Source:  BioPlex,STRINGDB
ZNF696
Tdark
Family:  TF
Novelty:  3.49300122
p_int:  0.989424894
p_ni:  0.010575106
p_wrong:  1e-9
Data Source:  BioPlex
TIMP1
Tbio
Family:  Enzyme
Novelty:  0.00020986
p_int:  0.985022977
p_ni:  0.014728711
p_wrong:  0.000248313
Score:  0.95
Data Source:  BioPlex,STRINGDB
IGF2
Tbio
Novelty:  0.00021277
p_int:  0.983864127
p_ni:  2.9e-7
p_wrong:  0.016135582
Score:  0.995
Data Source:  BioPlex,Reactome,STRINGDB
PLXDC2
Tbio
Novelty:  0.06496695
p_int:  0.980055149
p_ni:  0.019944851
Data Source:  BioPlex
GNB2
Tbio
Novelty:  0.08682553
p_int:  0.965513412
p_ni:  0.034486583
p_wrong:  5e-9
Data Source:  BioPlex
ZNF664
Tdark
Family:  TF
Novelty:  0.25879878
p_int:  0.947187987
p_ni:  0.000094004
p_wrong:  0.052718009
Score:  0.19
Data Source:  BioPlex,STRINGDB
Publication Statistics
PubMed Score  1392.57

PubMed score by year
PubTator Score  1541.8

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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