You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
GNAI3
Guanine nucleotide-binding protein G(k) subunit alpha

Protein Summary
Description
Heterotrimeric guanine nucleotide-binding proteins (G proteins) function as transducers downstream of G protein-coupled receptors (GPCRs) in numerous signaling cascades. The alpha chain contains the guanine nucleotide binding site and alternates between an active, GTP-bound state and an inactive, GDP-bound state. Signaling by an activated GPCR promotes GDP release and GTP binding. The alpha subunit has a low GTPase activity that converts bound GTP to GDP, thereby terminating the signal. Both GDP release and GTP hydrolysis are modulated by numerous regulatory proteins (PubMed:8774883, PubMed:18434541, PubMed:19478087). Signaling is mediated via effector proteins, such as adenylate cyclase. Inhibits adenylate cyclase activity, leading to decreased intracellular cAMP levels (PubMed:19478087). Stimulates the activity of receptor-regulated K(+) channels (PubMed:2535845). The active GTP-bound form prevents the association of RGS14 with centrosomes and is required for the translocation of RGS ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000369851
  • ENSP00000358867
  • ENSG00000065135

Symbol
  • 87U6
  • ARCND1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
1
interacting protein
1
molecular function
0.99
pathway
0.89
kinase perturbation
0.84


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 28.83   (req: < 5)
Gene RIFs: 29   (req: <= 3)
Antibodies: 198   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 28.83   (req: >= 5)
Gene RIFs: 29   (req: > 3)
Antibodies: 198   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 25
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body mass index
1
1
1
30.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body mass index
1
30.7
Protein Data Bank (6)
1 – 5 of 6
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (104)
ADP signalling through P2Y purinoceptor 12 (R-HSA-392170)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 28
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
ADP signalling through P2Y purinoceptor 12
Reactome
Activation of GABAB receptors
Reactome
Adenylate cyclase inhibitory pathway
Reactome
Chaperonin-mediated protein folding
Reactome
Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding
Name
Explore in Pharos
Explore in Source
ADP signalling through P2Y purinoceptor 12
Activation of GABAB receptors
Adenylate cyclase inhibitory pathway
Chaperonin-mediated protein folding
Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding
Gene Ontology Terms (38)
Items per page:
10
1 – 9 of 9
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Traceable Author Statement (TAS)
Reactome
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
Ensembl
Protein-Protein Interactions (432)
1 – 10 of 432
GNAI1
Tbio
Novelty: 0.0488971
p_int: 0.999999997
p_ni: 3e-9
Score: 0.994
Data Source: BioPlex,STRINGDB
RGS12
Tbio
Novelty: 0.02857864
p_int: 0.999999992
p_ni: 3e-9
p_wrong: 4e-9
Score: 0.98
Data Source: BioPlex,STRINGDB
GNAO1
Tbio
Novelty: 0.00315097
p_int: 0.999999749
p_ni: 2.5e-7
Score: 0.938
Data Source: BioPlex,STRINGDB
GNG4
Tbio
Novelty: 0.14371438
p_int: 0.999999514
p_ni: 4.86e-7
Score: 0.983
Data Source: BioPlex,STRINGDB
RGS14
Tbio
Novelty: 0.01986201
p_int: 0.999999215
p_ni: 2.38e-7
p_wrong: 5.46e-7
Score: 0.996
Data Source: BioPlex,STRINGDB
GPSM1
Tbio
Novelty: 0.03510582
p_int: 0.999999175
p_ni: 7.97e-7
p_wrong: 2.7e-8
Score: 0.984
Data Source: BioPlex,STRINGDB
GNAT2
Tbio
Novelty: 0.01683655
p_int: 0.999998882
p_ni: 0.000001032
p_wrong: 8.7e-8
Score: 0.915
Data Source: BioPlex,STRINGDB
ANKRD13B
Tdark
Novelty: 1.45055536
p_int: 0.99999845
p_ni: 4e-9
p_wrong: 0.000001546
Score: 0.316
Data Source: BioPlex,STRINGDB
RAP1GAP
Tbio
Family: Enzyme
Novelty: 0.0111232
p_int: 0.99999641
p_ni: 2.5e-8
p_wrong: 0.000003565
Score: 0.529
Data Source: BioPlex,STRINGDB
GNB2
Tbio
Novelty: 0.08682553
p_int: 0.999979578
p_ni: 0.000020422
Score: 0.99
Data Source: BioPlex,STRINGDB
Publication Statistics
PubMed Score  28.83

PubMed score by year
PubTator Score  42.5

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer