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Tbio
KRT7
Keratin, type II cytoskeletal 7

Protein Summary
Description
Blocks interferon-dependent interphase and stimulates DNA synthesis in cells. Involved in the translational regulation of the human papillomavirus type 16 E7 mRNA (HPV16 E7). The protein encoded by this gene is a member of the keratin gene family. The type II cytokeratins consist of basic or neutral proteins which are arranged in pairs of heterotypic keratin chains coexpressed during differentiation of simple and stratified epithelial tissues. This type II cytokeratin is specifically expressed in the simple epithelia lining the cavities of the internal organs and in the gland ducts and blood vessels. The genes encoding the type II cytokeratins are clustered in a region of chromosome 12q12-q13. Alternative splicing may result in several transcript variants; however, not all variants have been fully described. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000331817
  • ENSP00000329243
  • ENSG00000135480

Symbol
  • SCL
  • K7
  • CK7
  • SCL
  • K2C7
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
gene perturbation
0.95
PubMedID
0.9
interacting protein
0.87
ligand (protein) perturbation
0.83
transcription factor perturbation
0.8


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2476.93   (req: < 5)
Gene RIFs: 80   (req: <= 3)
Antibodies: 2183   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2476.93   (req: >= 5)
Gene RIFs: 80   (req: > 3)
Antibodies: 2183   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Data Bank (1)
1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (3)
Developmental Biology (R-HSA-1266738)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 2 of 2
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Developmental Biology
Reactome
Keratinization
Name
Explore in Pharos
Explore in Source
Developmental Biology
Keratinization
Gene Ontology Terms (10)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Electronic Annotation (IEA)
InterPro
Protein-Protein Interactions (144)
1 – 10 of 144
KRT18
Tbio
Novelty: 0.00069055
Score: 0.956
Data Source: STRINGDB
KRT19
Tbio
Novelty: 0.00043162
Score: 0.955
Data Source: STRINGDB
KRT17
Tbio
Novelty: 0.00278761
Score: 0.955
Data Source: STRINGDB
KRT13
Tbio
Novelty: 0.00468754
Score: 0.949
Data Source: STRINGDB
KRT14
Tbio
Novelty: 0.00088743
Score: 0.944
Data Source: STRINGDB
KRT16
Tbio
Novelty: 0.00503235
Score: 0.939
Data Source: STRINGDB
KRT20
Tbio
Novelty: 0.00132004
Score: 0.939
Data Source: STRINGDB
KRT9
Tbio
Novelty: 0.00787691
Score: 0.936
Data Source: STRINGDB
KRT15
Tbio
Novelty: 0.00351898
Score: 0.935
Data Source: STRINGDB
KRT10
Tbio
Novelty: 0.00166073
Score: 0.934
Data Source: STRINGDB
Publication Statistics
PubMed Score  2476.93

PubMed score by year
PubTator Score  1318.02

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer