Protein Summary
Initiates the extrinsic pathway of blood coagulation. Serine protease that circulates in the blood in a zymogen form. Factor VII is converted to factor VIIa by factor Xa, factor XIIa, factor IXa, or thrombin by minor proteolysis. In the presence of tissue factor and calcium ions, factor VIIa then converts factor X to factor Xa by limited proteolysis. Factor VIIa will also convert factor IX to factor IXa in the presence of tissue factor and calcium. This gene encodes coagulation factor VII which is a vitamin K-dependent factor essential for hemostasis. This factor circulates in the blood in a zymogen form, and is converted to an active form by either factor IXa, factor Xa, factor XIIa, or thrombin by minor proteolysis. Upon activation of the factor VII, a heavy chain containing a catalytic domain and a light chain containing 2 EGF-like domains are generated, and two chains are held together by a disulfide bond. In the presence of factor III and calcium ions, the activated factor then fu ...more
- ENST00000346342
- ENSP00000329546
- ENSG00000057593
- ENST00000375581
- ENSP00000364731
- SPCA
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
---|---|---|---|
biological term | 1 | ||
protein domain | 1 | ||
interacting protein | 0.86 | ||
gene perturbation | 0.85 | ||
kinase perturbation | 0.81 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 3862.79 (req: < 5)
Gene RIFs: 294 (req: <= 3)
Antibodies: 580 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 3862.79 (req: >= 5)
Gene RIFs: 294 (req: > 3)
Antibodies: 580 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 29
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligands: 325
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
Related Tools

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (325)
Protein-Protein Interactions (95)
C1QL1
Novelty: 0.11689088
p_int: 0.970664662
p_ni: 0.029216152
p_wrong: 0.000119187
Score: 0.235
Data Source: BioPlex,STRINGDB
NMU
Novelty: 0.00326109
p_int: 0.928034855
p_ni: 0.070480579
p_wrong: 0.001484566
Score: 0.345
Data Source: BioPlex,STRINGDB
CRELD2
Novelty: 0.09438775
p_int: 0.803870921
p_ni: 0.174242374
p_wrong: 0.021886705
Score: 0.416
Data Source: BioPlex,STRINGDB
Nearest Tclin Targets
Pathways (22)
Reactome (12)
KEGG (1)
PathwayCommons (2)
WikiPathways (7)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|---|
Reactome | BMAL1:CLOCK,NPAS2 activates circadian gene expression | ||||
Reactome | Circadian Clock | ||||
Reactome | Extrinsic Pathway of Fibrin Clot Formation | ||||
Reactome | Formation of Fibrin Clot (Clotting Cascade) | ||||
Reactome | Gamma carboxylation, hypusine formation and arylsulfatase activation | ||||
Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|
BMAL1:CLOCK,NPAS2 activates circadian gene expression | ||||
Circadian Clock | ||||
Extrinsic Pathway of Fibrin Clot Formation | ||||
Formation of Fibrin Clot (Clotting Cascade) | ||||
Gamma carboxylation, hypusine formation and arylsulfatase activation | ||||
Viral Interactions (0)
Gene Ontology Terms (36)
Functions (4)
Components (7)
Processes (25)
GO Term | Evidence | Assigned by | ||
---|---|---|---|---|
Traceable Author Statement (TAS) | ProtInc | |||
Traceable Author Statement (TAS) | ProtInc | |||
Inferred from Electronic Annotation (IEA) | InterPro | |||
Inferred from Electronic Annotation (IEA) | Ensembl | |||
Disease Associations ()
GWAS Traits (7)
Items per page:
1 – 5 of 7
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|---|---|
factor VII measurement | 2 | 8 | 8 | 99.7 | |||||
prothrombin time measurement | 2 | 5 | 5 | 99 | |||||
reticulocyte measurement | 3 | 3 | 3 | 73.2 | |||||
tissue factor measurement | 1 | 1 | 1 | 57.3 | |||||
reticulocyte count | 1 | 1 | 1 | 35 | |||||
Items per page:
1 – 5 of 7
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|
factor VII measurement | 8 | 99.7 | |||||
prothrombin time measurement | 5 | 99 | |||||
reticulocyte measurement | 3 | 73.2 | |||||
tissue factor measurement | 1 | 57.3 | |||||
reticulocyte count | 1 | 35 | |||||
Find similar targets by:
IDG Resources
Orthologs (12)
1 – 5 of 12
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|---|---|
Chimp | coagulation factor VII | VGNC:7831 | 744785 | |||||
Macaque | coagulation factor VII | 721933 | ||||||
Mouse | MGI:109325 | 14068 | ||||||
Rat | RGD:628678 | 260320 | ||||||
Dog | coagulation factor VII | VGNC:40552 | 607661 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|
Chimp | coagulation factor VII | |||||
Macaque | coagulation factor VII | |||||
Mouse | ||||||
Rat | ||||||
Dog | coagulation factor VII | |||||
Publication Statistics
PubMed Score 3862.79
PubMed score by year
PubTator Score 355.30
PubTator score by year
Related Publications
Text Mined References (439)
GeneRif Annotations (294)
Items per page:
0 of 0
PMID | Year | Title |
---|