Tchem F7 Coagulation factor VII

Protein Summary

Description

Initiates the extrinsic pathway of blood coagulation. Serine protease that circulates in the blood in a zymogen form. Factor VII is converted to factor VIIa by factor Xa, factor XIIa, factor IXa, or thrombin by minor proteolysis. In the presence of tissue factor and calcium ions, factor VIIa then converts factor X to factor Xa by limited proteolysis. Factor VIIa will also convert factor IX to factor IXa in the presence of tissue factor and calcium. This gene encodes coagulation factor VII which is a vitamin K-dependent factor essential for hemostasis. This factor circulates in the blood in a zymogen form, and is converted to an active form by either factor IXa, factor Xa, factor XIIa, or thrombin by minor proteolysis. Upon activation of the factor VII, a heavy chain containing a catalytic domain and a light chain containing 2 EGF-like domains are generated, and two chains are held together by a disulfide bond. In the presence of factor III and calcium ions, the activated factor then further activates the coagulation cascade by converting factor IX to factor IXa and/or factor X to factor Xa. Defects in this gene can cause coagulopathy. Alternative splicing results in multiple transcript variants encoding different isoforms that may undergo similar proteolytic processing to generate mature polypeptides. [provided by RefSeq, Aug 2015]

Uniprot Accession IDs

• P08709
• B0YJC8
• Q14339
• Q5JVF1
• Q5JVF2
• Q9UD52
• Q9UD53
• Q9UD54

Gene Name

• F7

Ensembl ID

• ENST00000346342
• ENSP00000329546
• ENSG00000057593
• ENST00000375581
• ENSP00000364731

Symbol

• SPCA

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
biological term	1
protein domain	1
interacting protein	0.86
gene perturbation	0.85
kinase perturbation	0.81

Protein Classes

PANTHER Classes

Protein / ... / Serine Protease / Coagulation Factor Vii

DTO Classes

Protein / Enzyme / Protease / Serine Protease / Coagulation Factor Vii

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3862.79   (req: < 5)

Gene RIFs: 294   (req: <= 3)

Antibodies: 580   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3862.79   (req: >= 5)

Gene RIFs: 294   (req: > 3)

Antibodies: 580   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 29

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 325

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Protein Sequence and Structure

Residue Counts

Protein Sequence

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Expression Data (0 Tissues)

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No expression data found

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Target Illumination GWAS Analytics (TIGA)

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GENEVA

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

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GlyGen

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

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ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

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Approved Drugs (0)

No approved drugs found

Active Ligands (325)

Explore Active Ligands

1 – 10 of 325

CHEMBL96433

F7Tchem Enzyme

pKi : 7.11

CHEMBL3127463

F7Tchem Enzyme

pKi : 6.47

CHEMBL282830

F7Tchem Enzyme

pKi : 9.19

CHEMBL27852

F7Tchem Enzyme

pKi : 8

CHEMBL284436

F7Tchem Enzyme

pKi : 6.42

CHEMBL265315

F7Tchem Enzyme

pKi : 6.78

CHEMBL4634303

F7Tchem Enzyme

pIC50 : 7.66

CHEMBL4646710

F7Tchem Enzyme

pIC50 : 7.92

CHEMBL4640835

F7Tchem Enzyme

pIC50 : 7.68

US9174974, Example 19

F7Tchem Enzyme

pKi : 6.72

Protein-Protein Interactions (95)

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1 – 10 of 95

• See Interactions on String-DB

C1QL1

Tdark

Novelty:  0.11689088

p_int:  0.970664662

p_ni:  0.029216152

p_wrong:  0.000119187

Score:  0.235

Data Source:  BioPlex,STRINGDB

NMU

Tbio

Novelty:  0.00326109

p_int:  0.928034855

p_ni:  0.070480579

p_wrong:  0.001484566

Score:  0.345

Data Source:  BioPlex,STRINGDB

CRELD2

Tbio

Novelty:  0.09438775

p_int:  0.803870921

p_ni:  0.174242374

p_wrong:  0.021886705

Score:  0.416

Data Source:  BioPlex,STRINGDB

F3

Tchem

Novelty:  0.00006457

Score:  0.999

Data Source:  Reactome,STRINGDB

TFPI

Tchem

Novelty:  0.00060355

Score:  0.979

Data Source:  Reactome,STRINGDB

GGCX

Tclin

Family:  Enzyme

Novelty:  0.00819484

Score:  0.975

Data Source:  Reactome,STRINGDB

F9

Tchem

Family:  Enzyme

Novelty:  0.00032127

Score:  0.972

Data Source:  Reactome,STRINGDB

SERPINC1

Tclin

Novelty:  0.00008721

Score:  0.966

Data Source:  STRINGDB

F10

Tclin

Family:  Enzyme

Novelty:  0.00063008

Score:  0.964

Data Source:  Reactome,STRINGDB

FURIN

Tchem

Family:  Enzyme

Novelty:  0.00055079

Score:  0.91

Data Source:  Reactome,STRINGDB

Nearest Tclin Targets

Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.

Pathways (22)

Reactome (12)

KEGG (1)

PathwayCommons (2)

WikiPathways (7)

BMAL1:CLOCK,NPAS2 activates circadian gene expression (R-HSA-1368108)

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Data Source	Name	Explore in Pharos	Explore in Source
Reactome	BMAL1:CLOCK,NPAS2 activates circadian gene expression	27 targets	R-HSA-1368108
Reactome	Circadian Clock	69 targets	R-HSA-400253
Reactome	Extrinsic Pathway of Fibrin Clot Formation	5 targets	R-HSA-140834
Reactome	Formation of Fibrin Clot (Clotting Cascade)	39 targets	R-HSA-140877
Reactome	Gamma carboxylation, hypusine formation and arylsulfatase activation	39 targets	R-HSA-163841

Name	Explore in Pharos	Explore in Source
BMAL1:CLOCK,NPAS2 activates circadian gene expression	27 targets	R-HSA-1368108
Circadian Clock	69 targets	R-HSA-400253
Extrinsic Pathway of Fibrin Clot Formation	5 targets	R-HSA-140834
Formation of Fibrin Clot (Clotting Cascade)	39 targets	R-HSA-140877
Gamma carboxylation, hypusine formation and arylsulfatase activation	39 targets	R-HSA-163841

Viral Interactions (0)

No viral interactions found

Gene Ontology Terms (36)

Functions (4)

Components (7)

Processes (25)

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1 – 4 of 4

GO Term	Evidence	Assigned by
serine-type endopeptidase activity	Traceable Author Statement (TAS)	ProtInc
serine-type peptidase activity	Traceable Author Statement (TAS)	ProtInc
calcium ion binding	Inferred from Electronic Annotation (IEA)	InterPro
signaling receptor binding	Inferred from Electronic Annotation (IEA)	Ensembl

Disease Associations ()

No disease associations found

GWAS Traits (7)

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5

1 – 5 of 7

GWAS Trait	EFO ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
factor VII measurement	EFO_0004619	2	8	8		99.7
prothrombin time measurement	EFO_0008390	2	5	5		99
reticulocyte measurement	EFO_0010700	3	3	3		73.2
tissue factor measurement	EFO_0010623	1	1	1		57.3
reticulocyte count	EFO_0007986	1	1	1		35

• Explore on Target Illumination GWAS Analytics (TIGA)

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5

1 – 5 of 7

GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
factor VII measurement	EFO_0004619	8		99.7
prothrombin time measurement	EFO_0008390	5		99
reticulocyte measurement	EFO_0010700	3		73.2
tissue factor measurement	EFO_0010623	1		57.3
reticulocyte count	EFO_0007986	1		35

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UniProt Keyword Find Similar Targets

No Header	No Header
3D-structure
Alternative splicing
Blood coagulation
Calcium
Cleavage on pair of basic residues
Complete proteome
Direct protein sequencing
Disease mutation
Disulfide bond
EGF-like domain

GWAS Trait Find Similar Targets

No Header	No Header
atrial fibrillation
factor VII measurement
osteoarthritis
prothrombin time measurement
reticulocyte count
reticulocyte measurement
tissue factor measurement

MGI Phenotype Find Similar Targets

No Header	No Header
adipose tissue phenotype
cardiovascular system phenotype
craniofacial phenotype
growth/size/body region phenotype
homeostasis/metabolism phenotype
mortality/aging
skeleton phenotype

IDG Resources

No IDG generated resources found

Orthologs (12)

1 – 5 of 12

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Chimp	coagulation factor VII	VGNC:7831	744785
Macaque	coagulation factor VII		721933
Mouse	coagulation factor VII	MGI:109325	14068
Rat	coagulation factor VII	RGD:628678	260320
Dog	coagulation factor VII	VGNC:40552	607661

Species	Name	OMA	EggNOG	Inparanoid
Chimp	coagulation factor VII
Macaque	coagulation factor VII
Mouse	coagulation factor VII
Rat	coagulation factor VII
Dog	coagulation factor VII

Publication Statistics

PubMed Score 3862.79

PubMed score by year

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PubTator Score 355.30

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Related Publications

Text Mined References (439)

GeneRif Annotations (294)

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PMID	Year	Title