Tchem F7 Coagulation factor VII

Protein Summary

Description

Initiates the extrinsic pathway of blood coagulation. Serine protease that circulates in the blood in a zymogen form. Factor VII is converted to factor VIIa by factor Xa, factor XIIa, factor IXa, or thrombin by minor proteolysis. In the presence of tissue factor and calcium ions, factor VIIa then converts factor X to factor Xa by limited proteolysis. Factor VIIa will also convert factor IX to factor IXa in the presence of tissue factor and calcium. This gene encodes coagulation factor VII which is a vitamin K-dependent factor essential for hemostasis. This factor circulates in the blood in a zymogen form, and is converted to an active form by either factor IXa, factor Xa, factor XIIa, or thrombin by minor proteolysis. Upon activation of the factor VII, a heavy chain containing a catalytic domain and a light chain containing 2 EGF-like domains are generated, and two chains are held together by a disulfide bond. In the presence of factor III and calcium ions, the activated factor then further activates the coagulation cascade by converting factor IX to factor IXa and/or factor X to factor Xa. Defects in this gene can cause coagulopathy. Alternative splicing results in multiple transcript variants encoding different isoforms that may undergo similar proteolytic processing to generate mature polypeptides. [provided by RefSeq, Aug 2015]

Uniprot Accession IDs

• P08709
• B0YJC8
• Q14339
• Q5JVF1
• Q5JVF2
• Q9UD52
• Q9UD53
• Q9UD54

Gene Name

• F7

Ensembl ID

• ENST00000346342
• ENSP00000329546
• ENSG00000057593
• ENST00000375581
• ENSP00000364731

Symbol

• SPCA

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
biological term	1
protein domain	1
interacting protein	0.86
gene perturbation	0.85
kinase perturbation	0.81

Protein Classes

PANTHER Classes

Protein / ... / Serine Protease / Coagulation Factor Vii

DTO Classes

Protein / Enzyme / Protease / Serine Protease / Coagulation Factor Vii

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 4072.16   (req: < 5)

Gene RIFs: 294   (req: <= 3)

Antibodies: 580   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 4072.16   (req: >= 5)

Gene RIFs: 294   (req: > 3)

Antibodies: 580   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 29

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 325

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0