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Tchem
F7
Coagulation factor VII

Protein Summary
Description
Initiates the extrinsic pathway of blood coagulation. Serine protease that circulates in the blood in a zymogen form. Factor VII is converted to factor VIIa by factor Xa, factor XIIa, factor IXa, or thrombin by minor proteolysis. In the presence of tissue factor and calcium ions, factor VIIa then converts factor X to factor Xa by limited proteolysis. Factor VIIa will also convert factor IX to factor IXa in the presence of tissue factor and calcium. This gene encodes coagulation factor VII which is a vitamin K-dependent factor essential for hemostasis. This factor circulates in the blood in a zymogen form, and is converted to an active form by either factor IXa, factor Xa, factor XIIa, or thrombin by minor proteolysis. Upon activation of the factor VII, a heavy chain containing a catalytic domain and a light chain containing 2 EGF-like domains are generated, and two chains are held together by a disulfide bond. In the presence of factor III and calcium ions, the activated factor then fu ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000346342
  • ENSP00000329546
  • ENSG00000057593
  • ENST00000375581
  • ENSP00000364731

Symbol
  • SPCA
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological term
1
protein domain
1
interacting protein
0.86
gene perturbation
0.85
kinase perturbation
0.81


Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
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GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
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GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3862.79   (req: < 5)
Gene RIFs: 294   (req: <= 3)
Antibodies: 580   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3862.79   (req: >= 5)
Gene RIFs: 294   (req: > 3)
Antibodies: 580   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 29
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 325
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (7)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
factor VII measurement
2
8
8
99.7
prothrombin time measurement
2
5
5
99
reticulocyte measurement
3
3
3
73.2
tissue factor measurement
1
1
1
57.3
reticulocyte count
1
1
1
35
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
factor VII measurement
8
99.7
prothrombin time measurement
5
99
reticulocyte measurement
3
73.2
tissue factor measurement
1
57.3
reticulocyte count
1
35
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
coagulation factor VII
VGNC:7831
744785
Macaque
coagulation factor VII
721933
Mouse
MGI:109325
14068
Rat
RGD:628678
260320
Dog
coagulation factor VII
VGNC:40552
607661
Species
Name
OMA
EggNOG
Inparanoid
Chimp
coagulation factor VII
Macaque
coagulation factor VII
Mouse
Rat
Dog
coagulation factor VII
Protein Structure (108 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P08709-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 5 of 108
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (22)
BMAL1:CLOCK,NPAS2 activates circadian gene expression (R-HSA-1368108)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 12
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
BMAL1:CLOCK,NPAS2 activates circadian gene expression
Reactome
Circadian Clock
Reactome
Extrinsic Pathway of Fibrin Clot Formation
Reactome
Formation of Fibrin Clot (Clotting Cascade)
Reactome
Gamma carboxylation, hypusine formation and arylsulfatase activation
Name
Explore in Pharos
Explore in Source
BMAL1:CLOCK,NPAS2 activates circadian gene expression
Circadian Clock
Extrinsic Pathway of Fibrin Clot Formation
Formation of Fibrin Clot (Clotting Cascade)
Gamma carboxylation, hypusine formation and arylsulfatase activation
Protein-Protein Interactions (95)
1 – 10 of 95
C1QL1
Tdark
Novelty:  0.11689088
p_int:  0.970664662
p_ni:  0.029216152
p_wrong:  0.000119187
Score:  0.235
Data Source:  BioPlex,STRINGDB
NMU
Tbio
Novelty:  0.00326109
p_int:  0.928034855
p_ni:  0.070480579
p_wrong:  0.001484566
Score:  0.345
Data Source:  BioPlex,STRINGDB
CRELD2
Tbio
Novelty:  0.09438775
p_int:  0.803870921
p_ni:  0.174242374
p_wrong:  0.021886705
Score:  0.416
Data Source:  BioPlex,STRINGDB
F3
Tchem
Novelty:  0.00006457
Score:  0.999
Data Source:  Reactome,STRINGDB
TFPI
Tchem
Novelty:  0.00060355
Score:  0.979
Data Source:  Reactome,STRINGDB
GGCX
Tclin
Family:  Enzyme
Novelty:  0.00819484
Score:  0.975
Data Source:  Reactome,STRINGDB
F9
Tchem
Family:  Enzyme
Novelty:  0.00032127
Score:  0.972
Data Source:  Reactome,STRINGDB
SERPINC1
Tclin
Novelty:  0.00008721
Score:  0.966
Data Source:  STRINGDB
F10
Tclin
Family:  Enzyme
Novelty:  0.00063008
Score:  0.964
Data Source:  Reactome,STRINGDB
FURIN
Tchem
Family:  Enzyme
Novelty:  0.00055079
Score:  0.91
Data Source:  Reactome,STRINGDB
Publication Statistics
PubMed Score  3862.79

PubMed score by year
PubTator Score  355.3

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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