RPS17
40S ribosomal protein S17
Protein Summary
Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of four RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 40S subunit. The protein belongs to the S17E family of ribosomal proteins and is located in the cytoplasm. Mutations in this gene cause Diamond-Blackfan anemia 4. Alternative splicing of this gene results in multiple transcript variants. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. [provided by RefSeq, Apr 2014]
- ENST00000330244
- ENSP00000346046
- ENSG00000182774
- ENST00000617731
- ENSP00000483755
- ENSG00000278229
- ENST00000647841
- ENSP00000498019
- RPS17L
- S17
- DBA4
- RPS17L
- RPS17L1
- RPS17L2
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
disease perturbation | 1 | ||
interacting protein | 1 | ||
kinase perturbation | 0.95 | ||
gene perturbation | 0.86 | ||
transcription factor perturbation | 0.84 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 167.57 (req: < 5)
Gene RIFs: 7 (req: <= 3)
Antibodies: 128 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 167.57 (req: >= 5)
Gene RIFs: 7 (req: > 3)
Antibodies: 128 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 9
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0