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Tbio
IL3
Interleukin-3

Protein Summary
Description
Granulocyte/macrophage colony-stimulating factors are cytokines that act in hematopoiesis by controlling the production, differentiation, and function of 2 related white cell populations of the blood, the granulocytes and the monocytes-macrophages. This CSF induces granulocytes, macrophages, mast cells, stem cells, erythroid cells, eosinophils and megakaryocytes. The protein encoded by this gene is a potent growth promoting cytokine. This cytokine is capable of supporting the proliferation of a broad range of hematopoietic cell types. It is involved in a variety of cell activities such as cell growth, differentiation and apoptosis. This cytokine has been shown to also possess neurotrophic activity, and it may be associated with neurologic disorders. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000296870
  • ENSP00000296870
  • ENSG00000164399

Symbol
  • IL-3
  • MCGF
  • MULTI-CSF
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
tissue
0.82
biological term
0.8
biological process
0.78
disease
0.67
chemical
0.65


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3036.38   (req: < 5)
Gene RIFs: 82   (req: <= 3)
Antibodies: 722   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3036.38   (req: >= 5)
Gene RIFs: 82   (req: > 3)
Antibodies: 722   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 15
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Data Bank (3)
1 – 3 of 3
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (50)
Cytokine Signaling in Immune system (R-HSA-1280215)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 17
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cytokine Signaling in Immune system
Reactome
FLT3 Signaling
Reactome
Gene expression (Transcription)
Reactome
Generic Transcription Pathway
Reactome
Immune System
Name
Explore in Pharos
Explore in Source
Cytokine Signaling in Immune system
FLT3 Signaling
Gene expression (Transcription)
Generic Transcription Pathway
Immune System
Gene Ontology Terms (17)
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Traceable Author Statement (TAS)
UniProtKB
Traceable Author Statement (TAS)
Reactome
Traceable Author Statement (TAS)
Reactome
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (300)
1 – 10 of 300
IL3RA
Tclin
Novelty: 0.00358526
Score: 0.997
Data Source: Reactome,STRINGDB
CSF2
Tbio
Novelty: 0.00012299
Score: 0.995
Data Source: STRINGDB
IL2
Tchem
Novelty: 0.00004362
Score: 0.989
Data Source: STRINGDB
IL5
Tclin
Novelty: 0.00032832
Score: 0.987
Data Source: STRINGDB
STAT5B
Tchem
Family: TF
Novelty: 0.00091216
Score: 0.984
Data Source: Reactome,STRINGDB
STAT5A
Tchem
Family: TF
Novelty: 0.00091229
Score: 0.983
Data Source: Reactome,STRINGDB
CSF2RB
Tclin
Novelty: 0.0255155
Score: 0.978
Data Source: Reactome,STRINGDB
JAK2
Tclin
Family: Kinase
Novelty: 0.00028252
Score: 0.966
Data Source: Reactome,STRINGDB
HRAS
Tchem
Family: Enzyme
Novelty: 0.00008788
Score: 0.963
Data Source: STRINGDB
IL5RA
Tclin
Novelty: 0.02117904
Score: 0.962
Data Source: STRINGDB
Publication Statistics
PubMed Score  3036.38

PubMed score by year
PubTator Score  1945.94

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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