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Tbio
SERPINF2
Alpha-2-antiplasmin

Protein Summary
Description
Serine protease inhibitor. The major targets of this inhibitor are plasmin and trypsin, but it also inactivates matriptase-3/TMPRSS7 and chymotrypsin. This gene encodes a member of the serpin family of serine protease inhibitors. The protein is a major inhibitor of plasmin, which degrades fibrin and various other proteins. Consequently, the proper function of this gene has a major role in regulating the blood clotting pathway. Mutations in this gene result in alpha-2-plasmin inhibitor deficiency, which is characterized by severe hemorrhagic diathesis. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2009]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000324015
  • ENSP00000321853
  • ENSG00000167711
  • ENST00000382061
  • ENSP00000371493
  • ENST00000450523
  • ENSP00000403877
  • ENST00000618883
  • ENSP00000479005
  • ENSG00000276838
  • ENST00000622842
  • ENSP00000481874

Symbol
  • AAP
  • PLI
  • AAP
  • API
  • PLI
  • A2AP
  • ALPHA-2-PI
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0.99
gene perturbation
0.84
cellular component
0.65
disease
0.62
biological term
0.57


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1660.66   (req: < 5)
Gene RIFs: 37   (req: <= 3)
Antibodies: 496   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1660.66   (req: >= 5)
Gene RIFs: 37   (req: > 3)
Antibodies: 496   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 23
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (4)
Items per page:
1 – 4 of 4
GWAS Trait
EFO ID
ENSG ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
testosterone measurement
1
1
1
86.3
testosterone measurement
1
1
1
86.3
serum albumin measurement
1
1
1
31.9
serum albumin measurement
1
1
1
31.9
Items per page:
1 – 4 of 4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
testosterone measurement
1
86.3
testosterone measurement
1
86.3
serum albumin measurement
1
31.9
serum albumin measurement
1
31.9
Pathways (20)
Dissolution of Fibrin Clot (R-HSA-75205)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 5
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Dissolution of Fibrin Clot
Reactome
Hemostasis
Reactome
Platelet activation, signaling and aggregation
Reactome
Platelet degranulation
Reactome
Response to elevated platelet cytosolic Ca2+
Name
Explore in Pharos
Explore in Source
Dissolution of Fibrin Clot
Hemostasis
Platelet activation, signaling and aggregation
Platelet degranulation
Response to elevated platelet cytosolic Ca2+
Protein-Protein Interactions (158)
1 – 10 of 158
RNASEH1
Tchem
Family: Enzyme
Novelty: 0.01838314
p_int: 0.999995035
p_ni: 0.000004965
Data Source: BioPlex
DAPP1
Tbio
Novelty: 0.05145215
p_int: 0.999983638
p_ni: 0.000016354
p_wrong: 8e-9
Data Source: BioPlex
PLAT
Tclin
Family: Enzyme
Novelty: 0.00017503
p_int: 0.999942222
p_ni: 0.000057778
Score: 0.984
Data Source: BioPlex,STRINGDB
POMGNT2
Tbio
Family: Enzyme
Novelty: 0.15109569
p_int: 0.99975874
p_ni: 0.00024126
Data Source: BioPlex
HIBADH
Tbio
Family: Enzyme
Novelty: 0.03861647
p_int: 0.998567909
p_ni: 0.00143209
Data Source: BioPlex
EMB
Tbio
Novelty: 0.00135577
p_int: 0.988870429
p_ni: 0.009530179
p_wrong: 0.001599392
Data Source: BioPlex
PLG
Tclin
Family: Enzyme
Novelty: 0.00004806
Score: 0.995
Data Source: Reactome,STRINGDB
A2M
Tbio
Novelty: 0.00070446
Score: 0.98
Data Source: STRINGDB
FGA
Tbio
Novelty: 0.00107227
Score: 0.975
Data Source: STRINGDB
ALB
Tchem
Novelty: 0.00000616
Score: 0.962
Data Source: STRINGDB
Publication Statistics
PubMed Score  1660.66

PubMed score by year
PubTator Score  1319.8

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer