You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
ITGA5
Integrin alpha-5

Protein Summary
Description
Integrin alpha-5/beta-1 (ITGA5:ITGB1) is a receptor for fibronectin and fibrinogen. It recognizes the sequence R-G-D in its ligands. ITGA5:ITGB1 binds to PLA2G2A via a site (site 2) which is distinct from the classical ligand-binding site (site 1) and this induces integrin conformational changes and enhanced ligand binding to site 1 (PubMed:18635536, PubMed:25398877). ITGA5:ITGB1 acts as a receptor for fibrillin-1 (FBN1) and mediates R-G-D-dependent cell adhesion to FBN1 (PubMed:12807887, PubMed:17158881). ITGA5:ITGB1 is a receptor for IL1B and binding is essential for IL1B signaling (PubMed:29030430). (Microbial infection) Integrin ITGA5:ITGB1 acts as a receptor for Human metapneumovirus. (Microbial infection) Integrin ITGA2:ITGB1 acts as a receptor for Human parvovirus B19. (Microbial infection) In case of HIV-1 infection, the interaction with extracellular viral Tat protein seems to enhance angiogenesis in Kaposi's sarcoma lesions. The product of this gene belongs to the integrin al ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000293379
  • ENSP00000293379
  • ENSG00000161638

Symbol
  • FNRA
  • FNRA
  • CD49e
  • VLA-5
  • VLA5A
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological term
0.99
transcription factor perturbation
0.97
interacting protein
0.94
biological process
0.86
gene perturbation
0.86


Related Tools
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 310.54   (req: < 5)
Gene RIFs: 266   (req: <= 3)
Antibodies: 1060   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 310.54   (req: >= 5)
Gene RIFs: 266   (req: > 3)
Antibodies: 1060   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 28
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
integrin subunit alpha 5
VGNC:5435
451958
Macaque
integrin subunit alpha 5
574315
Mouse
MGI:96604
16402
Rat
RGD:2925
315346
Dog
integrin subunit alpha 5
VGNC:42127
486493
Species
Name
OMA
EggNOG
Inparanoid
Chimp
integrin subunit alpha 5
Macaque
integrin subunit alpha 5
Mouse
Rat
Dog
integrin subunit alpha 5
Protein Structure (6 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P08648-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 5 of 6
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (51)
Axon guidance (R-HSA-422475)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 15
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Axon guidance
Reactome
Cell surface interactions at the vascular wall
Reactome
Developmental Biology
Reactome
Elastic fibre formation
Reactome
Extracellular matrix organization
Name
Explore in Pharos
Explore in Source
Axon guidance
Cell surface interactions at the vascular wall
Developmental Biology
Elastic fibre formation
Extracellular matrix organization
Gene Ontology Terms (39)
Items per page:
10
1 – 6 of 6
GO Term
Evidence
Assigned by
Traceable Author Statement (TAS)
BHF-UCL
Traceable Author Statement (TAS)
BHF-UCL
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (203)
1 – 10 of 203
LGALS8
Tchem
Novelty: 0.00623836
p_int: 0.999999793
p_ni: 1.99e-7
p_wrong: 8e-9
Score: 0.18
Data Source: BioPlex,STRINGDB
TXNDC16
Tdark
Novelty: 0.25365147
p_int: 0.999966411
p_ni: 0.000025049
p_wrong: 0.00000854
Data Source: BioPlex
FAM19A4
Tbio
Novelty: 0.04305684
p_int: 0.999859303
p_ni: 0.000097564
p_wrong: 0.000043133
Data Source: BioPlex
ADAM32
Tdark
Family: Enzyme
Novelty: 0.36071191
p_int: 0.999808098
p_ni: 0.000058471
p_wrong: 0.000133431
Score: 0.198
Data Source: BioPlex,STRINGDB
BTNL3
Tdark
Novelty: 0.27343899
p_int: 0.999652221
p_ni: 0.000347021
p_wrong: 7.58e-7
Score: 0.19
Data Source: BioPlex,STRINGDB
LY86
Tbio
Novelty: 0.00314575
p_int: 0.993568232
p_ni: 0.004522295
p_wrong: 0.001909473
Data Source: BioPlex
ITGB1
Tclin
Novelty: 0.00055626
Score: 0.999
Data Source: Reactome,STRINGDB
FN1
Tchem
Novelty: 0.00003647
Score: 0.99
Data Source: Reactome,STRINGDB
ITGB3
Tclin
Novelty: 0.00067255
Score: 0.987
Data Source: STRINGDB
TLN1
Tbio
Novelty: 0.00803981
Score: 0.981
Data Source: STRINGDB
Publication Statistics
PubMed Score  310.54

PubMed score by year
PubTator Score  240.34

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
Find similar targets by: