You are using an outdated browser. Please upgrade your browser to improve your experience.

Tclin
FCGR3A
Low affinity immunoglobulin gamma Fc region receptor III-A

Protein Classes
Protein Summary
Description
Receptor for the Fc region of IgG. Binds complexed or aggregated IgG and also monomeric IgG. Mediates antibody-dependent cellular cytotoxicity (ADCC) and other antibody-dependent responses, such as phagocytosis. This gene encodes a receptor for the Fc portion of immunoglobulin G, and it is involved in the removal of antigen-antibody complexes from the circulation, as well as other other antibody-dependent responses. This gene (FCGR3A) is highly similar to another nearby gene (FCGR3B) located on chromosome 1. The receptor encoded by this gene is expressed on natural killer (NK) cells as an integral membrane glycoprotein anchored through a transmembrane peptide, whereas FCGR3B is expressed on polymorphonuclear neutrophils (PMN) where the receptor is anchored through a phosphatidylinositol (PI) linkage. Mutations in this gene have been linked to susceptibility to recurrent viral infections, susceptibility to systemic lupus erythematosus, and alloimmune neonatal neutropenia. Alternatively ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000367967
  • ENSP00000356944
  • ENSG00000203747
  • ENST00000436743
  • ENSP00000416607
  • ENST00000443193
  • ENSP00000392047

Symbol
  • CD16A
  • FCG3
  • FCGR3
  • IGFR3
  • CD16
  • FCG3
  • CD16A
  • FCGR3
  • IGFR3
  • IMD20
  • FCR-10
  • FCRIII
  • FCGRIII
  • FCRIIIA
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological term
0.98
drug
0.81
disease
0.76
tissue sample
0.67
cellular component
0.57


Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2169.1   (req: < 5)
Gene RIFs: 287   (req: <= 3)
Antibodies: 2092   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2169.1   (req: >= 5)
Gene RIFs: 287   (req: > 3)
Antibodies: 2092   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 4
GWAS Traits (33)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
serum non-albumin protein measurement
1
6
6
99.2
blood protein measurement
2
4
4
98
basophil percentage of leukocytes
1
4
4
94.1
hematocrit
3
4
4
91.1
basophil count
2
5
6
88.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
serum non-albumin protein measurement
6
99.2
blood protein measurement
4
98
basophil percentage of leukocytes
4
94.1
hematocrit
4
91.1
basophil count
6
88.2
Orthologs (7)
1 – 5 of 7
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
low affinity immunoglobulin gamma Fc region receptor III-B
457457
Macaque
Fc-gamma RIII
720006
Mouse
MGI:2179523
246256
Rat
RGD:1303067
304966
Dog
low affinity immunoglobulin gamma Fc region receptor III
478984
Species
Name
OMA
EggNOG
Inparanoid
Chimp
low affinity immunoglobulin gamma Fc region receptor III-B
Macaque
Fc-gamma RIII
Mouse
Rat
Dog
low affinity immunoglobulin gamma Fc region receptor III
Protein Structure (12 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P08637-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 5 of 12
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (41)
Adaptive Immune System (R-HSA-1280218)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 8
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Adaptive Immune System
Reactome
FCGR activation
Reactome
Fcgamma receptor (FCGR) dependent phagocytosis
Reactome
Immune System
Reactome
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
Name
Explore in Pharos
Explore in Source
Adaptive Immune System
FCGR activation
Fcgamma receptor (FCGR) dependent phagocytosis
Immune System
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
Gene Ontology Terms (8)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (210)
1 – 10 of 210
RAB32
Tbio
Family:  Enzyme
Novelty:  0.02514559
p_int:  0.872222528
p_ni:  0.127517837
p_wrong:  0.000259636
Score:  0.193
Data Source:  BioPlex,STRINGDB
NCS1
Tbio
Novelty:  0.0051468
p_int:  0.80139489
p_ni:  0.197593383
p_wrong:  0.001011727
Score:  0.199
Data Source:  BioPlex,STRINGDB
GK
Tbio
Family:  Kinase
Novelty:  0.00617547
p_int:  0.79180536
p_ni:  0.208194639
p_wrong:  1e-9
Score:  0.813
Data Source:  BioPlex,STRINGDB
FCGR3B
Tbio
Novelty:  0.000429
Score:  0.983
Data Source:  STRINGDB
FCGR1A
Tclin
Novelty:  0.00073204
Score:  0.977
Data Source:  STRINGDB
HCK
Tclin
Family:  Kinase
Novelty:  0.00237485
Score:  0.975
Data Source:  STRINGDB
FCER1G
Tbio
Novelty:  0.00783146
Score:  0.97
Data Source:  STRINGDB
SYK
Tclin
Family:  Kinase
Novelty:  0.00058994
Score:  0.956
Data Source:  Reactome,STRINGDB
LILRB2
Tbio
Novelty:  0.00545569
Score:  0.956
Data Source:  STRINGDB
FGR
Tchem
Family:  Kinase
Novelty:  0.00262848
Score:  0.954
Data Source:  STRINGDB
Publication Statistics
PubMed Score  2169.10

PubMed score by year
PubTator Score  2206.52

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
Find similar targets by: