Tclin FCGR3A Low affinity immunoglobulin gamma Fc region receptor III-A

Protein Summary

Description

Receptor for the Fc region of IgG. Binds complexed or aggregated IgG and also monomeric IgG. Mediates antibody-dependent cellular cytotoxicity (ADCC) and other antibody-dependent responses, such as phagocytosis. This gene encodes a receptor for the Fc portion of immunoglobulin G, and it is involved in the removal of antigen-antibody complexes from the circulation, as well as other other antibody-dependent responses. This gene (FCGR3A) is highly similar to another nearby gene (FCGR3B) located on chromosome 1. The receptor encoded by this gene is expressed on natural killer (NK) cells as an integral membrane glycoprotein anchored through a transmembrane peptide, whereas FCGR3B is expressed on polymorphonuclear neutrophils (PMN) where the receptor is anchored through a phosphatidylinositol (PI) linkage. Mutations in this gene have been linked to susceptibility to recurrent viral infections, susceptibility to systemic lupus erythematosus, and alloimmune neonatal neutropenia. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• P08637
• A2N6W9
• Q53FJ0
• Q53FL6
• Q5EBR4
• Q65ZM6
• Q6PIJ0

Gene Name

• FCGR3A

Ensembl ID

• ENST00000367967
• ENSP00000356944
• ENSG00000203747
• ENST00000436743
• ENSP00000416607
• ENST00000443193
• ENSP00000392047

Symbol

• CD16A
• FCG3
• FCGR3
• IGFR3
• CD16
• FCG3
• CD16A
• FCGR3
• IGFR3
• IMD20
• FCR-10
• FCRIII
• FCGRIII
• FCRIIIA

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
biological term	0.98
drug	0.81
disease	0.76
tissue sample	0.67
cellular component	0.57

Protein Classes

PANTHER Classes

Protein / Cell Adhesion Molecule / Low Affinity Immunoglobulin Gamma Fc Region Receptor Iii-a

DTO Classes

Protein / Cell Adhesion / Low Affinity Immunoglobulin Gamma Fc Region Receptor Iii-a

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2481.73   (req: < 5)

Gene RIFs: 338   (req: <= 3)

Antibodies: 2092   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2481.73   (req: >= 5)

Gene RIFs: 338   (req: > 3)

Antibodies: 2092   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 4