Tclin HCK Tyrosine-protein kinase HCK

Protein Summary

Description

Non-receptor tyrosine-protein kinase found in hematopoietic cells that transmits signals from cell surface receptors and plays an important role in the regulation of innate immune responses, including neutrophil, monocyte, macrophage and mast cell functions, phagocytosis, cell survival and proliferation, cell adhesion and migration. Acts downstream of receptors that bind the Fc region of immunoglobulins, such as FCGR1A and FCGR2A, but also CSF3R, PLAUR, the receptors for IFNG, IL2, IL6 and IL8, and integrins, such as ITGB1 and ITGB2. During the phagocytic process, mediates mobilization of secretory lysosomes, degranulation, and activation of NADPH oxidase to bring about the respiratory burst. Plays a role in the release of inflammatory molecules. Promotes reorganization of the actin cytoskeleton and actin polymerization, formation of podosomes and cell protrusions. Inhibits TP73-mediated transcription activation and TP73-mediated apoptosis. Phosphorylates CBL in response to activation of immunoglobulin gamma Fc region receptors. Phosphorylates ADAM15, BCR, ELMO1, FCGR2A, GAB1, GAB2, RAPGEF1, STAT5B, TP73, VAV1 and WAS. The protein encoded by this gene is a member of the Src family of tyrosine kinases. This protein is primarily hemopoietic, particularly in cells of the myeloid and B-lymphoid lineages. It may help couple the Fc receptor to the activation of the respiratory burst. In addition, it may play a role in neutrophil migration and in the degranulation of neutrophils. Multiple isoforms with different subcellular distributions are produced due to both alternative splicing and the use of alternative translation initiation codons, including a non-AUG (CUG) codon. [provided by RefSeq, Feb 2010]

Uniprot Accession IDs

• P08631
• A8K1I1
• B4DQB6
• E1P5M2
• Q29RX1
• Q2VPE2
• Q504R5
• Q5T7K1
• Q5T7K2
• Q96CC0
• Q9H5Y5
• Q9NUA4
• Q9UMJ5

Gene Name

• HCK

Ensembl ID

• ENST00000518730
• ENSP00000427757
• ENSG00000101336
• ENST00000520553
• ENSP00000429848
• ENST00000534862
• ENSP00000444986
• ENST00000538448
• ENSP00000441169
• ENST00000629881
• ENSP00000486627
• ENST00000639405
• ENSP00000491964

Symbol

• JTK9
• p59Hck
• p61Hck

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
viral protein	1
virus	1
PubMedID	0.99
biological process	0.98
protein domain	0.97

Protein Classes

DTO Classes

Protein / Kinase / Protein Kinase / Tk Group / Src Family / Tyrosine-protein Kinase Hck

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 501.47   (req: < 5)

Gene RIFs: 60   (req: <= 3)

Antibodies: 545   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 501.47   (req: >= 5)

Gene RIFs: 60   (req: > 3)

Antibodies: 545   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 33

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 116

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 4