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Tclin
HCK
Tyrosine-protein kinase HCK

Protein Summary
Description
Non-receptor tyrosine-protein kinase found in hematopoietic cells that transmits signals from cell surface receptors and plays an important role in the regulation of innate immune responses, including neutrophil, monocyte, macrophage and mast cell functions, phagocytosis, cell survival and proliferation, cell adhesion and migration. Acts downstream of receptors that bind the Fc region of immunoglobulins, such as FCGR1A and FCGR2A, but also CSF3R, PLAUR, the receptors for IFNG, IL2, IL6 and IL8, and integrins, such as ITGB1 and ITGB2. During the phagocytic process, mediates mobilization of secretory lysosomes, degranulation, and activation of NADPH oxidase to bring about the respiratory burst. Plays a role in the release of inflammatory molecules. Promotes reorganization of the actin cytoskeleton and actin polymerization, formation of podosomes and cell protrusions. Inhibits TP73-mediated transcription activation and TP73-mediated apoptosis. Phosphorylates CBL in response to activation ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000518730
  • ENSP00000427757
  • ENSG00000101336
  • ENST00000520553
  • ENSP00000429848
  • ENST00000534862
  • ENSP00000444986
  • ENST00000538448
  • ENSP00000441169
  • ENST00000629881
  • ENSP00000486627
  • ENST00000639405
  • ENSP00000491964

Symbol
  • JTK9
  • p59Hck
  • p61Hck
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
viral protein
1
virus
1
PubMedID
0.99
biological process
0.98
protein domain
0.97


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 501.47   (req: < 5)
Gene RIFs: 46   (req: <= 3)
Antibodies: 545   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 501.47   (req: >= 5)
Gene RIFs: 46   (req: > 3)
Antibodies: 545   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 33
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 116
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 4
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (5)
ProKinO
Thumbnail image for ProKinO
The ProKinO is a protein kinase-specific ontology, which provides a controlled vocabulary of terms, their hierarchy, and relationships unifying sequence, structure, function, mutation and pathway information on kinases.
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Protein-Protein Interactions (287)
ITGB2
Tclin
Novelty:  0.00185859
Score:  0.979
Data Source:  STRINGDB
PLCG1
Tchem
Family:  Enzyme
Novelty:  0.00110273
Score:  0.979
Data Source:  STRINGDB
CRKL
Tbio
Novelty:  0.0051181
Score:  0.978
Data Source:  STRINGDB
VAV1
Tchem
Novelty:  0.00180518
Score:  0.977
Data Source:  STRINGDB
FCGR3A
Tclin
Novelty:  0.0004214
Score:  0.975
Data Source:  STRINGDB
EGFR
Tclin
Family:  Kinase
Novelty:  0.00007274
Score:  0.975
Data Source:  STRINGDB
FCGR1A
Tclin
Novelty:  0.00073204
Score:  0.974
Data Source:  STRINGDB
CBL
Tbio
Family:  Enzyme
Novelty:  0.00114929
Score:  0.973
Data Source:  STRINGDB
SOS1
Tchem
Novelty:  0.00285343
Score:  0.972
Data Source:  STRINGDB
FGR
Tchem
Family:  Kinase
Novelty:  0.00262848
Score:  0.971
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (98)
Cytokine Signaling in Immune system (R-HSA-1280215)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 16
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cytokine Signaling in Immune system
Reactome
Disease
Reactome
FCGR activation
Reactome
FLT3 Signaling
Reactome
Fcgamma receptor (FCGR) dependent phagocytosis
Name
Explore in Pharos
Explore in Source
Cytokine Signaling in Immune system
Disease
FCGR activation
FLT3 Signaling
Fcgamma receptor (FCGR) dependent phagocytosis
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (44)
Find Similar Targets
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Physical Interaction (IPI)
CAFA
Inferred from Mutant Phenotype (IMP)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Disease Associations (null)
No disease associations found
GWAS Traits (10)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
suntan
1
1
1
82
1
1
0
1.1
49.3
appendicular lean mass
1
1
1
39.7
urinary albumin to creatinine ratio
2
2
2
35.8
body height
1
1
1
30.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
suntan
1
82
0
1.1
49.3
appendicular lean mass
1
39.7
urinary albumin to creatinine ratio
2
35.8
body height
1
30.2
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
HCK proto-oncogene, Src family tyrosine kinase
VGNC:10154
458163
Macaque
HCK proto-oncogene, Src family tyrosine kinase
715723
Mouse
MGI:96052
15162
Rat
RGD:2785
25734
Dog
HCK proto-oncogene, Src family tyrosine kinase
VGNC:41618
485828
Species
Name
OMA
EggNOG
Inparanoid
Chimp
HCK proto-oncogene, Src family tyrosine kinase
Macaque
HCK proto-oncogene, Src family tyrosine kinase
Mouse
Rat
Dog
HCK proto-oncogene, Src family tyrosine kinase
Publication Statistics
PubMed Score 501.47
PubMed score by year
PubTator Score 188.44
PubTator score by year
Patents
Patents by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title