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Tbio
SNRNP70
U1 small nuclear ribonucleoprotein 70 kDa

Protein Summary
Description
Component of the spliceosomal U1 snRNP, which is essential for recognition of the pre-mRNA 5' splice-site and the subsequent assembly of the spliceosome (PubMed:19325628, PubMed:25555158). SNRNP70 binds to the loop I region of U1-snRNA (PubMed:2467746, PubMed:19325628, PubMed:25555158). Isoform 3: Truncated isoforms that lack the RRM domain cannot bind U1-snRNA. Isoform 4: Truncated isoforms that lack the RRM domain cannot bind U1-snRNA.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000221448
  • ENSP00000221448
  • ENSG00000104852
  • ENST00000401730
  • ENSP00000385077
  • ENST00000595231
  • ENSP00000471006
  • ENST00000598441
  • ENSP00000472998
  • ENST00000601065
  • ENSP00000468952

Symbol
  • RNPU1Z
  • RPU1
  • SNRP70
  • U1AP1
  • RPU1
  • Snp1
  • U1AP
  • U170K
  • U1RNP
  • RNPU1Z
  • SNRP70
  • U1-70K
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
interacting protein
1
hub protein
0.97
kinase perturbation
0.97
ligand (protein) perturbation
0.96
transcription factor binding site profile
0.89


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 804.91   (req: < 5)
Gene RIFs: 29   (req: <= 3)
Antibodies: 181   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 804.91   (req: >= 5)
Gene RIFs: 29   (req: > 3)
Antibodies: 181   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
systolic blood pressure
1
1
1
61
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
systolic blood pressure
1
61
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
small nuclear ribonucleoprotein U1 subunit 70
VGNC:8612
747202
Macaque
small nuclear ribonucleoprotein U1 subunit 70
719090
Mouse
MGI:98341
20637
Rat
RGD:1307120
361574
Dog
small nuclear ribonucleoprotein U1 subunit 70
VGNC:46609
484388
Species
Name
OMA
EggNOG
Inparanoid
Chimp
small nuclear ribonucleoprotein U1 subunit 70
Macaque
small nuclear ribonucleoprotein U1 subunit 70
Mouse
Rat
Dog
small nuclear ribonucleoprotein U1 subunit 70
Protein Structure (6 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P08621-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 5 of 6
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (7)
Metabolism of RNA (R-HSA-8953854)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Metabolism of RNA
Reactome
Processing of Capped Intron-Containing Pre-mRNA
Reactome
mRNA Splicing
Reactome
mRNA Splicing - Major Pathway
Name
Explore in Pharos
Explore in Source
Metabolism of RNA
Processing of Capped Intron-Containing Pre-mRNA
mRNA Splicing
mRNA Splicing - Major Pathway
Gene Ontology Terms (15)
Items per page:
10
1 – 3 of 3
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Mutant Phenotype (IMP)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Protein-Protein Interactions (398)
1 – 10 of 398
RBMXL1
Tdark
Novelty: 0.81422952
p_int: 0.999999644
p_ni: 3.56e-7
Data Source: BioPlex
CMTR2
Tbio
Family: Enzyme
Novelty: 0.11208282
p_int: 0.9999994
p_ni: 1.07e-7
p_wrong: 4.93e-7
Score: 0.622
Data Source: BioPlex,STRINGDB
GEMIN8
Tbio
Novelty: 0.19515325
p_int: 0.999998595
p_ni: 0.000001405
Score: 0.656
Data Source: BioPlex,STRINGDB
GEMIN7
Tbio
Novelty: 0.04835353
p_int: 0.999996624
p_ni: 0.000003368
p_wrong: 8e-9
Score: 0.611
Data Source: BioPlex,STRINGDB
SMN1
Tbio
Family: Epigenetic
Novelty: 0.0008085
p_int: 0.999989707
p_ni: 3e-9
p_wrong: 0.000010289
Score: 0.746
Data Source: BioPlex,STRINGDB
SNRPGP15
Tdark
p_int: 0.999987589
p_ni: 0.000012411
Data Source: BioPlex
SNRPF
Tdark
Novelty: 0.17624854
p_int: 0.999953645
p_ni: 0.000046355
Score: 0.999
Data Source: BioPlex,STRINGDB
SNRPE
Tbio
Novelty: 0.02033423
p_int: 0.99994439
p_ni: 0.00005561
Score: 0.999
Data Source: BioPlex,STRINGDB
SNRPN
Tbio
Novelty: 0.002157
p_int: 0.999882665
p_ni: 0.000117335
Score: 0.994
Data Source: BioPlex,STRINGDB
GEMIN4
Tbio
Novelty: 0.03731756
p_int: 0.999861476
p_ni: 0.000138524
Score: 0.731
Data Source: BioPlex,STRINGDB
Publication Statistics
PubMed Score  804.91

PubMed score by year
PubTator Score  389.86

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer