Tbio SNRNP70 U1 small nuclear ribonucleoprotein 70 kDa

Protein Summary

Description

Component of the spliceosomal U1 snRNP, which is essential for recognition of the pre-mRNA 5' splice-site and the subsequent assembly of the spliceosome (PubMed:19325628, PubMed:25555158). SNRNP70 binds to the loop I region of U1-snRNA (PubMed:2467746, PubMed:19325628, PubMed:25555158). Isoform 3: Truncated isoforms that lack the RRM domain cannot bind U1-snRNA. Isoform 4: Truncated isoforms that lack the RRM domain cannot bind U1-snRNA.

Uniprot Accession IDs

• P08621
• B3KUA3
• P78493
• P78494
• Q15364
• Q15686
• Q15687
• Q15689
• Q99377
• Q9UE45
• Q9UE46
• Q9UE47
• Q9UE48
• Q9UFQ6
• U1 snRNP 70 kDa

Gene Name

• SNRNP70

Ensembl ID

• ENST00000221448
• ENSP00000221448
• ENSG00000104852
• ENST00000401730
• ENSP00000385077
• ENST00000595231
• ENSP00000471006
• ENST00000598441
• ENSP00000472998
• ENST00000601065
• ENSP00000468952

Symbol

• RNPU1Z
• RPU1
• SNRP70
• U1AP1
• RPU1
• Snp1
• U1AP
• U170K
• U1RNP
• RNPU1Z
• SNRP70
• U1-70K

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
interacting protein	1
hub protein	0.97
kinase perturbation	0.97
ligand (protein) perturbation	0.96
transcription factor binding site profile	0.89

Protein Classes

PANTHER Classes

Protein / Nucleic Acid Binding / Rna Binding Protein / Mrna Processing Factor / Mrna Splicing Factor / U1 Small Nuclear Ribonucleoprotein 70 Kda

DTO Classes

Protein / Nucleic Acid Binding / Rna Binding Protein / Mrna Processing Factor / Mrna Splicing Factor / U1 Small Nuclear Ribonucleoprotein 70 Kda

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 815.46   (req: < 5)

Gene RIFs: 29   (req: <= 3)

Antibodies: 181   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 815.46   (req: >= 5)

Gene RIFs: 29   (req: > 3)

Antibodies: 181   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Protein Sequence and Structure

Residue Counts

Protein Sequence

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Expression Data (0 Tissues)

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No expression data found

Related Tools

Target Illumination GWAS Analytics (TIGA)

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

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GENEVA

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

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GlyGen

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

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ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

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Approved Drugs (0)

No approved drugs found

Active Ligands (0)

No active ligands found

Protein-Protein Interactions (398)

Explore Interacting Targets

1 – 10 of 398

• See Interactions on String-DB

RBMXL1

Tdark

Novelty:  0.81422952

p_int:  0.999999644

p_ni:  3.56e-7

Data Source:  BioPlex

CMTR2

Tbio

Family:  Enzyme

Novelty:  0.11208282

p_int:  0.9999994

p_ni:  1.07e-7

p_wrong:  4.93e-7

Score:  0.622

Data Source:  BioPlex,STRINGDB

GEMIN8

Tbio

Novelty:  0.19515325

p_int:  0.999998595

p_ni:  0.000001405

Score:  0.656

Data Source:  BioPlex,STRINGDB

GEMIN7

Tbio

Novelty:  0.04835353

p_int:  0.999996624

p_ni:  0.000003368

p_wrong:  8e-9

Score:  0.611

Data Source:  BioPlex,STRINGDB

SMN1

Tchem

Family:  Epigenetic

Novelty:  0.0008085

p_int:  0.999989707

p_ni:  3e-9

p_wrong:  0.000010289

Score:  0.746

Data Source:  BioPlex,STRINGDB

SNRPGP15

Tdark

p_int:  0.999987589

p_ni:  0.000012411

Data Source:  BioPlex

SNRPF

Tdark

Novelty:  0.17624854

p_int:  0.999953645

p_ni:  0.000046355

Score:  0.999

Data Source:  BioPlex,STRINGDB

SNRPE

Tbio

Novelty:  0.02033423

p_int:  0.99994439

p_ni:  0.00005561

Score:  0.999

Data Source:  BioPlex,STRINGDB

SNRPN

Tbio

Novelty:  0.002157

p_int:  0.999882665

p_ni:  0.000117335

Score:  0.994

Data Source:  BioPlex,STRINGDB

GEMIN4

Tbio

Novelty:  0.03731756

p_int:  0.999861476

p_ni:  0.000138524

Score:  0.731

Data Source:  BioPlex,STRINGDB

Nearest Tclin Targets

Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.

Pathways (7)

Reactome (4)

KEGG (1)

PathwayCommons (1)

WikiPathways (1)

Metabolism of RNA (R-HSA-8953854)

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Find Similar Targets

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5

1 – 4 of 4

Data Source	Name	Explore in Pharos	Explore in Source
Reactome	Metabolism of RNA	686 targets	R-HSA-8953854
Reactome	Processing of Capped Intron-Containing Pre-mRNA	241 targets	R-HSA-72203
Reactome	mRNA Splicing	188 targets	R-HSA-72172
Reactome	mRNA Splicing - Major Pathway	180 targets	R-HSA-72163

Name	Explore in Pharos	Explore in Source
Metabolism of RNA	686 targets	R-HSA-8953854
Processing of Capped Intron-Containing Pre-mRNA	241 targets	R-HSA-72203
mRNA Splicing	188 targets	R-HSA-72172
mRNA Splicing - Major Pathway	180 targets	R-HSA-72163

Viral Interactions (0)

No viral interactions found

Gene Ontology Terms (15)

Functions (3)

Components (6)

Processes (6)

Find Similar Targets

Items per page:

10

1 – 3 of 3

GO Term	Evidence	Assigned by
U1 snRNA binding	Inferred from Direct Assay (IDA)	UniProtKB
RNA binding	Inferred from Mutant Phenotype (IMP)	UniProtKB
mRNA binding	Inferred from Biological aspect of Ancestor (IBA)	GO_Central

Disease Associations ()

No disease associations found

GWAS Traits (8)

• Explore on Target Illumination GWAS Analytics (TIGA)

Items per page:

5

1 – 5 of 8

GWAS Trait	EFO ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
testosterone measurement	EFO_0004908	5	5	5		87.3
systolic blood pressure	EFO_0006335	1	1	1		67.7
body mass index	EFO_0004340	1	1	1		31.4
heel bone mineral density	EFO_0009270	1	1	1		31.4
electrocardiography	EFO_0004327	1	1	3		30.1

• Explore on Target Illumination GWAS Analytics (TIGA)

Items per page:

5

1 – 5 of 8

GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
testosterone measurement	EFO_0004908	5		87.3
systolic blood pressure	EFO_0006335	1		67.7
body mass index	EFO_0004340	1		31.4
heel bone mineral density	EFO_0009270	1		31.4
electrocardiography	EFO_0004327	3		30.1

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Find similar targets by:

UniProt Keyword Find Similar Targets

No Header	No Header
3D-structure
Acetylation
Alternative splicing
Complete proteome
Direct protein sequencing
Isopeptide bond
mRNA processing
Nucleus
Phosphoprotein
Reference proteome

GWAS Trait Find Similar Targets

No Header	No Header
body height
body mass index
electrocardiography
ferritin measurement
heel bone mineral density
puberty onset measurement
systolic blood pressure
testosterone measurement

IDG Resources

No IDG generated resources found

Orthologs (13)

1 – 5 of 13

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Chimp	small nuclear ribonucleoprotein U1 subunit 70	VGNC:8612	747202
Macaque	small nuclear ribonucleoprotein U1 subunit 70		719090
Mouse	small nuclear ribonucleoprotein 70 (U1)	MGI:98341	20637
Rat	small nuclear ribonucleoprotein U1 subunit 70	RGD:1307120	361574
Dog	small nuclear ribonucleoprotein U1 subunit 70	VGNC:46609	484388

Species	Name	OMA	EggNOG	Inparanoid
Chimp	small nuclear ribonucleoprotein U1 subunit 70
Macaque	small nuclear ribonucleoprotein U1 subunit 70
Mouse	small nuclear ribonucleoprotein 70 (U1)
Rat	small nuclear ribonucleoprotein U1 subunit 70
Dog	small nuclear ribonucleoprotein U1 subunit 70

Publication Statistics

PubMed Score 815.46

PubMed score by year

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PubTator Score 389.86

PubTator score by year

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Related Publications

Text Mined References (86)

GeneRif Annotations (29)

Items per page:

10

0 of 0

PMID	Year	Title