Tbio SNRNP70 U1 small nuclear ribonucleoprotein 70 kDa

Protein Summary

Description

Component of the spliceosomal U1 snRNP, which is essential for recognition of the pre-mRNA 5' splice-site and the subsequent assembly of the spliceosome (PubMed:19325628, PubMed:25555158). SNRNP70 binds to the loop I region of U1-snRNA (PubMed:2467746, PubMed:19325628, PubMed:25555158). Isoform 3: Truncated isoforms that lack the RRM domain cannot bind U1-snRNA. Isoform 4: Truncated isoforms that lack the RRM domain cannot bind U1-snRNA.

Uniprot Accession IDs

• P08621
• B3KUA3
• P78493
• P78494
• Q15364
• Q15686
• Q15687
• Q15689
• Q99377
• Q9UE45
• Q9UE46
• Q9UE47
• Q9UE48
• Q9UFQ6
• U1 snRNP 70 kDa

Gene Name

• SNRNP70

Ensembl ID

• ENST00000221448
• ENSP00000221448
• ENSG00000104852
• ENST00000401730
• ENSP00000385077
• ENST00000595231
• ENSP00000471006
• ENST00000598441
• ENSP00000472998
• ENST00000601065
• ENSP00000468952

Symbol

• RNPU1Z
• RPU1
• SNRP70
• U1AP1
• RPU1
• Snp1
• U1AP
• U170K
• U1RNP
• RNPU1Z
• SNRP70
• U1-70K

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
interacting protein	1
hub protein	0.97
kinase perturbation	0.97
ligand (protein) perturbation	0.96
transcription factor binding site profile	0.89

Protein Classes

PANTHER Classes

Protein / Nucleic Acid Binding / Rna Binding Protein / Mrna Processing Factor / Mrna Splicing Factor / U1 Small Nuclear Ribonucleoprotein 70 Kda

DTO Classes

Protein / Nucleic Acid Binding / Rna Binding Protein / Mrna Processing Factor / Mrna Splicing Factor / U1 Small Nuclear Ribonucleoprotein 70 Kda

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 956.46   (req: < 5)

Gene RIFs: 36   (req: <= 3)

Antibodies: 181   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 956.46   (req: >= 5)

Gene RIFs: 36   (req: > 3)

Antibodies: 181   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0