SNRNP70
U1 small nuclear ribonucleoprotein 70 kDa
Protein Summary
Component of the spliceosomal U1 snRNP, which is essential for recognition of the pre-mRNA 5' splice-site and the subsequent assembly of the spliceosome (PubMed:19325628, PubMed:25555158). SNRNP70 binds to the loop I region of U1-snRNA (PubMed:2467746, PubMed:19325628, PubMed:25555158). Isoform 3: Truncated isoforms that lack the RRM domain cannot bind U1-snRNA. Isoform 4: Truncated isoforms that lack the RRM domain cannot bind U1-snRNA.
- ENST00000221448
- ENSP00000221448
- ENSG00000104852
- ENST00000401730
- ENSP00000385077
- ENST00000595231
- ENSP00000471006
- ENST00000598441
- ENSP00000472998
- ENST00000601065
- ENSP00000468952
- RNPU1Z
- RPU1
- SNRP70
- U1AP1
- RPU1
- Snp1
- U1AP
- U170K
- U1RNP
- RNPU1Z
- SNRP70
- U1-70K
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
interacting protein | 1 | ||
hub protein | 0.97 | ||
kinase perturbation | 0.97 | ||
ligand (protein) perturbation | 0.96 | ||
transcription factor binding site profile | 0.89 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 956.46 (req: < 5)
Gene RIFs: 36 (req: <= 3)
Antibodies: 181 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 956.46 (req: >= 5)
Gene RIFs: 36 (req: > 3)
Antibodies: 181 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 9
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0