Tbio FGF4 Fibroblast growth factor 4

Protein Summary

Description

Plays an important role in the regulation of embryonic development, cell proliferation, and cell differentiation. Required for normal limb and cardiac valve development during embryogenesis. The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities and are involved in a variety of biological processes including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. This gene was identified by its oncogenic transforming activity. This gene and FGF3, another oncogenic growth factor, are located closely on chromosome 11. Co-amplification of both genes was found in various kinds of human tumors. Studies on the mouse homolog suggested a function in bone morphogenesis and limb development through the sonic hedgehog (SHH) signaling pathway. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• P08620
• B7U994
• FGF-4

Gene Name

• FGF4

Ensembl ID

• ENST00000168712
• ENSP00000168712
• ENSG00000075388

Symbol

• HST
• HSTF1
• KS3
• HST
• KFGF
• FGF-4
• HST-1
• HSTF1
• K-FGF
• HBGF-4
• HSTF-1

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
biological process	0.93
disease perturbation	0.74
PubMedID	0.67
cell type or tissue	0.62
transcription factor	0.62

Protein Classes

PANTHER Classes

Protein / Signaling Molecule / Growth Factor / Fibroblast Growth Factor 4

DTO Classes

Protein / Signaling / Growth Factor / Fibroblast Growth Factor 4

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 597.58   (req: < 5)

Gene RIFs: 27   (req: <= 3)

Antibodies: 400   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 597.58   (req: >= 5)

Gene RIFs: 27   (req: > 3)

Antibodies: 400   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 27

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0