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Tbio
CFH
Complement factor H

Protein Summary
Description
Factor H functions as a cofactor in the inactivation of C3b by factor I and also increases the rate of dissociation of the C3bBb complex (C3 convertase) and the (C3b)NBB complex (C5 convertase) in the alternative complement pathway. This gene is a member of the Regulator of Complement Activation (RCA) gene cluster and encodes a protein with twenty short consensus repeat (SCR) domains. This protein is secreted into the bloodstream and has an essential role in the regulation of complement activation, restricting this innate defense mechanism to microbial infections. Mutations in this gene have been associated with hemolytic-uremic syndrome (HUS) and chronic hypocomplementemic nephropathy. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Oct 2011]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000367429
  • ENSP00000356399
  • ENSG00000000971

Symbol
  • HF
  • HF1
  • HF2
  • FH
  • HF
  • HF1
  • HF2
  • HUS
  • FHL1
  • AHUS1
  • AMBP1
  • ARMD4
  • ARMS1
  • CFHL3
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological term
1
co-expressed gene
0.99
gene perturbation
0.96
disease
0.89
phenotype
0.82


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1613.64   (req: < 5)
Gene RIFs: 595   (req: <= 3)
Antibodies: 855   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1613.64   (req: >= 5)
Gene RIFs: 595   (req: > 3)
Antibodies: 855   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Data Bank (45)
1 – 5 of 45
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (170)
Complement cascade (R-HSA-166658)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Complement cascade
Reactome
Immune System
Reactome
Innate Immune System
Reactome
Regulation of Complement cascade
Name
Explore in Pharos
Explore in Source
Complement cascade
Immune System
Innate Immune System
Regulation of Complement cascade
Gene Ontology Terms (10)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Direct Assay (IDA)
BHF-UCL
Protein-Protein Interactions (109)
1 – 10 of 109
CFHR3
Tbio
Novelty: 0.02712836
p_int: 0.99551977
p_ni: 4.07e-7
p_wrong: 0.004479823
Score: 0.966
Data Source: BioPlex,STRINGDB
KLHL18
Tdark
Novelty: 1.55555556
p_int: 0.979446207
p_ni: 0.020000177
p_wrong: 0.000553616
Score: 0.193
Data Source: BioPlex,STRINGDB
MUT
Tbio
Family: Enzyme
Novelty: 0.00172221
p_int: 0.968147111
p_ni: 0.031852889
Score: 0.623
Data Source: BioPlex,STRINGDB
CFI
Tbio
Novelty: 0.00194994
Score: 0.999
Data Source: Reactome,STRINGDB
C3
Tbio
Novelty: 0.00025052
Score: 0.999
Data Source: Reactome,STRINGDB
CFHR1
Tbio
Novelty: 0.00805757
Score: 0.971
Data Source: STRINGDB
CFHR2
Tbio
Novelty: 0.11928994
Score: 0.948
Data Source: STRINGDB
CFB
Tchem
Novelty: 0.00128742
Score: 0.946
Data Source: Reactome,STRINGDB
ARMS2
Tbio
Novelty: 0.00399337
Score: 0.922
Data Source: STRINGDB
CRP
Tbio
Novelty: 0.0000246
Score: 0.869
Data Source: STRINGDB
Publication Statistics
PubMed Score  1613.64

PubMed score by year
PubTator Score  1744.96

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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