Protein Summary
Factor H functions as a cofactor in the inactivation of C3b by factor I and also increases the rate of dissociation of the C3bBb complex (C3 convertase) and the (C3b)NBB complex (C5 convertase) in the alternative complement pathway. This gene is a member of the Regulator of Complement Activation (RCA) gene cluster and encodes a protein with twenty short consensus repeat (SCR) domains. This protein is secreted into the bloodstream and has an essential role in the regulation of complement activation, restricting this innate defense mechanism to microbial infections. Mutations in this gene have been associated with hemolytic-uremic syndrome (HUS) and chronic hypocomplementemic nephropathy. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Oct 2011]
- ENST00000367429
- ENSP00000356399
- ENSG00000000971
- HF
- HF1
- HF2
- FH
- HF
- HF1
- HF2
- HUS
- FHL1
- AHUS1
- AMBP1
- ARMD4
- ARMS1
- CFHL3
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
biological term | 1 | ||
co-expressed gene | 0.99 | ||
gene perturbation | 0.96 | ||
disease | 0.89 | ||
phenotype | 0.82 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 1979.64 (req: < 5)
Gene RIFs: 595 (req: <= 3)
Antibodies: 855 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 1979.64 (req: >= 5)
Gene RIFs: 595 (req: > 3)
Antibodies: 855 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 6
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Expression Data (0 Tissues)
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (109)
CFHR3
Novelty: 0.01779009
p_int: 0.99551977
p_ni: 4.07e-7
p_wrong: 0.004479823
Score: 0.966
Data Source: BioPlex,STRINGDB
KLHL18
Novelty: 0.52915213
p_int: 0.979446207
p_ni: 0.020000177
p_wrong: 0.000553616
Score: 0.193
Data Source: BioPlex,STRINGDB
MUT
Family: Enzyme
Novelty: 0.00074807
p_int: 0.968147111
p_ni: 0.031852889
Score: 0.623
Data Source: BioPlex,STRINGDB
Nearest Tclin Targets
Pathways (170)
Reactome (4)
KEGG (2)
WikiPathways (164)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Complement cascade | ||||
Reactome | Immune System | ||||
Reactome | Innate Immune System | ||||
Reactome | Regulation of Complement cascade | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Complement cascade | ||||
Immune System | ||||
Innate Immune System | ||||
Regulation of Complement cascade | ||||
Viral Interactions (0)
Gene Ontology Terms (10)
Functions (2)
Components (4)
Processes (4)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Direct Assay (IDA) | BHF-UCL | |||
Inferred from Direct Assay (IDA) | BHF-UCL | |||
Disease Associations (null)
GWAS Traits (36)
Items per page:
1 – 5 of 36
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
14 | 17 | 0 | 2.4 | 100 | |||||
4 | 9 | 0 | 2.4 | 99.8 | |||||
blood protein measurement | 107 | 16 | 106 | 1.4 | 99.8 | ||||
atrophic macular degeneration | 2 | 7 | 0 | 2.6 | 99.3 | ||||
complement factor H measurement | 4 | 5 | 4 | 4253 | 99.1 | ||||
Items per page:
1 – 5 of 36
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
0 | 2.4 | 100 | |||||
0 | 2.4 | 99.8 | |||||
blood protein measurement | 106 | 1.4 | 99.8 | ||||
atrophic macular degeneration | 0 | 2.6 | 99.3 | ||||
complement factor H measurement | 4 | 4253 | 99.1 | ||||
Find similar targets by:
IDG Resources
Orthologs (9)
1 – 5 of 9
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | complement factor H | VGNC:1214 | 457601 | |||||
Mouse | MGI:88385 | 12628 | ||||||
Rat | RGD:620428 | 155012 | ||||||
Dog | complement factor H | 478952 | ||||||
Horse | complement factor H | 100051358 | ||||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | complement factor H | |||||
Mouse | ||||||
Rat | ||||||
Dog | complement factor H | |||||
Horse | complement factor H | |||||
Publication Statistics
PubMed Score 1979.64
PubMed score by year
PubTator Score 1744.96
PubTator score by year
Related Publications
Text Mined References (742)
GeneRif Annotations (595)
Items per page:
0 of 0
PMID | Year | Title |
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