Protein Summary
Factor H functions as a cofactor in the inactivation of C3b by factor I and also increases the rate of dissociation of the C3bBb complex (C3 convertase) and the (C3b)NBB complex (C5 convertase) in the alternative complement pathway. This gene is a member of the Regulator of Complement Activation (RCA) gene cluster and encodes a protein with twenty short consensus repeat (SCR) domains. This protein is secreted into the bloodstream and has an essential role in the regulation of complement activation, restricting this innate defense mechanism to microbial infections. Mutations in this gene have been associated with hemolytic-uremic syndrome (HUS) and chronic hypocomplementemic nephropathy. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Oct 2011]
- ENST00000367429
- ENSP00000356399
- ENSG00000000971
- HF
- HF1
- HF2
- FH
- HF
- HF1
- HF2
- HUS
- FHL1
- AHUS1
- AMBP1
- ARMD4
- ARMS1
- CFHL3
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
---|---|---|---|
biological term | 1 | ||
co-expressed gene | 0.99 | ||
gene perturbation | 0.96 | ||
disease | 0.89 | ||
phenotype | 0.82 | ||
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 1613.64 (req: < 5)
Gene RIFs: 595 (req: <= 3)
Antibodies: 855 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 1613.64 (req: >= 5)
Gene RIFs: 595 (req: > 3)
Antibodies: 855 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 6
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Protein Data Bank (45)
1 – 5 of 45
PDB Structure Id | Ligand | Method | Resolution (Ã…) | M.W. (kDa) | Pub Year | Title |
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PDB Structure Id | M.W. | Resolution | Pub Year |
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Pathways (170)
Reactome (4)
KEGG (2)
WikiPathways (164)
Click on a row in the table to change the structure displayed.
Items per page:
1 – 4 of 4
Data Source | Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|---|
Reactome | Complement cascade | ||||
Reactome | Immune System | ||||
Reactome | Innate Immune System | ||||
Reactome | Regulation of Complement cascade | ||||
Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|
Complement cascade | ||||
Immune System | ||||
Innate Immune System | ||||
Regulation of Complement cascade | ||||
Gene Ontology Terms (10)
Functions (2)
Components (4)
Processes (4)
Items per page:
10
1 – 2 of 2
GO Term | Evidence | Assigned by | ||
---|---|---|---|---|
Inferred from Direct Assay (IDA) | BHF-UCL | |||
Inferred from Direct Assay (IDA) | BHF-UCL | |||
Protein-Protein Interactions (109)
1 – 10 of 109
CFHR3
Novelty: 0.02712836
p_int: 0.99551977
p_ni: 4.07e-7
p_wrong: 0.004479823
Score: 0.966
Data Source: BioPlex,STRINGDB
KLHL18
Novelty: 1.55555556
p_int: 0.979446207
p_ni: 0.020000177
p_wrong: 0.000553616
Score: 0.193
Data Source: BioPlex,STRINGDB
MUT
Family: Enzyme
Novelty: 0.00172221
p_int: 0.968147111
p_ni: 0.031852889
Score: 0.623
Data Source: BioPlex,STRINGDB
CFI
Novelty: 0.00194994
Score: 0.999
Data Source: Reactome,STRINGDB
C3
Novelty: 0.00025052
Score: 0.999
Data Source: Reactome,STRINGDB
CFHR1
Novelty: 0.00805757
Score: 0.971
Data Source: STRINGDB
CFHR2
Novelty: 0.11928994
Score: 0.948
Data Source: STRINGDB
CFB
Novelty: 0.00128742
Score: 0.946
Data Source: Reactome,STRINGDB
ARMS2
Novelty: 0.00399337
Score: 0.922
Data Source: STRINGDB
CRP
Novelty: 0.0000246
Score: 0.869
Data Source: STRINGDB
Publication Statistics
PubMed Score 1613.64
PubMed score by year
PubTator Score 1744.96
PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
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