Tbio MYL3 Myosin light chain 3

Protein Summary

Description

Regulatory light chain of myosin. Does not bind calcium. MYL3 encodes myosin light chain 3, an alkali light chain also referred to in the literature as both the ventricular isoform and the slow skeletal muscle isoform. Mutations in MYL3 have been identified as a cause of mid-left ventricular chamber type hypertrophic cardiomyopathy. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• P08590
• B2R534
• Q9NRS8

Gene Name

• MYL3

Ensembl ID

• ENST00000292327
• ENSP00000292327
• ENSG00000160808
• ENST00000395869
• ENSP00000379210

Symbol

• CMH8
• VLC1
• VLCl
• MLC1V
• MLC1SB
• MLC-lV/sb

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
molecular function	0.79
gene perturbation	0.7
cellular component	0.62
PubMedID	0.58
tissue sample	0.58

Protein Classes

PANTHER Classes

Protein / Cytoskeletal Protein / Actin Family Cytoskeletal Protein / Myosin Light Chain 3

Protein / Calcium-binding Protein / Intracellular Calcium-sensing Protein / Calmodulin / Myosin Light Chain 3

DTO Classes

Protein / Calcium-binding Protein / Intracellular Calcium-sensing Protein / Calmodulin / Myosin Light Chain 3

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 202.5   (req: < 5)

Gene RIFs: 13   (req: <= 3)

Antibodies: 342   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 202.5   (req: >= 5)

Gene RIFs: 13   (req: > 3)

Antibodies: 342   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 12

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0