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Tclin
ADRB1
Beta-1 adrenergic receptor

Protein Summary
Description
Beta-adrenergic receptors mediate the catecholamine-induced activation of adenylate cyclase through the action of G proteins. This receptor binds epinephrine and norepinephrine with approximately equal affinity. Mediates Ras activation through G(s)-alpha- and cAMP-mediated signaling. The adrenergic receptors (subtypes alpha 1, alpha 2, beta 1, and beta 2) are a prototypic family of guanine nucleotide binding regulatory protein-coupled receptors that mediate the physiological effects of the hormone epinephrine and the neurotransmitter norepinephrine. Specific polymorphisms in this gene have been shown to affect the resting heart rate and can be involved in heart failure. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000369295
  • ENSP00000358301
  • ENSG00000043591

Symbol
  • ADRB1R
  • B1AR
  • RHR
  • B1AR
  • ADRB1R
  • BETA1AR
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
1
drug
1
molecular function
0.97
ligand (chemical)
0.95
chemical
0.94


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 849.73   (req: < 5)
Gene RIFs: 229   (req: <= 3)
Antibodies: 250   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 849.73   (req: >= 5)
Gene RIFs: 229   (req: > 3)
Antibodies: 250   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 26
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 233
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 42
Approved Drugs (42)
1 – 10 of 42
carvedilol
chemical structure image
vortioxetine
chemical structure image
dopamine
chemical structure image
norepinephrine
chemical structure image
propafenone
chemical structure image
droxidopa
chemical structure image
dobutamine
chemical structure image
pindolol
chemical structure image
labetalol
chemical structure image
levobunolol
chemical structure image
GWAS Traits (8)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
birth weight
3
1
3
86.8
parental genotype effect measurement
1
1
1
32.4
Agents acting on the renin-angiotensin system use measurement
1
1
1
29.6
waist-hip ratio
1
1
1
16.7
1
1
1
5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
birth weight
3
86.8
parental genotype effect measurement
1
32.4
Agents acting on the renin-angiotensin system use measurement
1
29.6
waist-hip ratio
1
16.7
1
5
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
adrenoceptor beta 1
VGNC:3799
466206
Mouse
MGI:87937
11554
Rat
RGD:2059
24925
Dog
adrenoceptor beta 1
VGNC:37676
493972
Cow
adrenoceptor beta 1
VGNC:50130
281604
Species
Name
OMA
EggNOG
Inparanoid
Chimp
adrenoceptor beta 1
Mouse
Rat
Dog
adrenoceptor beta 1
Cow
adrenoceptor beta 1
Protein Structure (1 Structure, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P08588-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (26)
Adrenoceptors (R-HSA-390696)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 8
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Adrenoceptors
Reactome
Amine ligand-binding receptors
Reactome
Class A/1 (Rhodopsin-like receptors)
Reactome
G alpha (s) signalling events
Reactome
GPCR downstream signalling
Name
Explore in Pharos
Explore in Source
Adrenoceptors
Amine ligand-binding receptors
Class A/1 (Rhodopsin-like receptors)
G alpha (s) signalling events
GPCR downstream signalling
Gene Ontology Terms (31)
Items per page:
10
1 – 10 of 10
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
BHF-UCL
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Physical Interaction (IPI)
BHF-UCL
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Traceable Author Statement (TAS)
ProtInc
Inferred from Electronic Annotation (IEA)
Ensembl
Protein-Protein Interactions (243)
1 – 10 of 243
GNB3
Tbio
Novelty: 0.0037117
Score: 0.958
Data Source: STRINGDB
POMC
Tbio
Novelty: 0.00002436
Score: 0.955
Data Source: STRINGDB
CRH
Tbio
Novelty: 0.000147
Score: 0.949
Data Source: STRINGDB
CALCA
Tbio
Novelty: 0.00010496
Score: 0.948
Data Source: STRINGDB
CALCA
Tclin
Novelty: 0.00010496
Score: 0.948
Data Source: STRINGDB
VIP
Tbio
Novelty: 0.00024946
Score: 0.946
Data Source: STRINGDB
GCG
Tchem
Novelty: 0.00004879
Score: 0.945
Data Source: STRINGDB
AVP
Tbio
Novelty: 0.00016475
Score: 0.945
Data Source: STRINGDB
ADCY5
Tchem
Family: Enzyme
Novelty: 0.00307839
Score: 0.945
Data Source: STRINGDB
NPS
Tbio
Novelty: 0.00692108
Score: 0.944
Data Source: STRINGDB
Publication Statistics
PubMed Score  849.73

PubMed score by year
PubTator Score  1039.85

PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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