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Tclin
ADRB1
Beta-1 adrenergic receptor

Protein Summary
Description
Beta-adrenergic receptors mediate the catecholamine-induced activation of adenylate cyclase through the action of G proteins. This receptor binds epinephrine and norepinephrine with approximately equal affinity. Mediates Ras activation through G(s)-alpha- and cAMP-mediated signaling. The adrenergic receptors (subtypes alpha 1, alpha 2, beta 1, and beta 2) are a prototypic family of guanine nucleotide binding regulatory protein-coupled receptors that mediate the physiological effects of the hormone epinephrine and the neurotransmitter norepinephrine. Specific polymorphisms in this gene have been shown to affect the resting heart rate and can be involved in heart failure. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000369295
  • ENSP00000358301
  • ENSG00000043591

Symbol
  • ADRB1R
  • B1AR
  • RHR
  • B1AR
  • ADRB1R
  • BETA1AR
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
1
drug
1
molecular function
0.97
ligand (chemical)
0.95
chemical
0.94


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 864.79   (req: < 5)
Gene RIFs: 229   (req: <= 3)
Antibodies: 250   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 864.79   (req: >= 5)
Gene RIFs: 229   (req: > 3)
Antibodies: 250   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 26
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 494
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 45
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (45)
isoprenaline
Rendered image for isoprenaline
carvedilol
Rendered image for carvedilol
droxidopa
Rendered image for droxidopa
vortioxetine
Rendered image for vortioxetine
darifenacin
Rendered image for darifenacin
dobutamine
Rendered image for dobutamine
norepinephrine
Rendered image for norepinephrine
propafenone
Rendered image for propafenone
dopamine
Rendered image for dopamine
pindolol
Rendered image for pindolol
Protein-Protein Interactions (243)
GNB3
Tbio
Novelty:  0.0037117
Score:  0.958
Data Source:  STRINGDB
POMC
Tbio
Novelty:  0.00002436
Score:  0.955
Data Source:  STRINGDB
CRH
Tbio
Novelty:  0.000147
Score:  0.949
Data Source:  STRINGDB
P01258
Tbio
Novelty:  0.00010496
Score:  0.948
Data Source:  STRINGDB
P06881
Tclin
Novelty:  0.00010496
Score:  0.948
Data Source:  STRINGDB
VIP
Tbio
Novelty:  0.00024946
Score:  0.946
Data Source:  STRINGDB
GCG
Tchem
Novelty:  0.00004879
Score:  0.945
Data Source:  STRINGDB
AVP
Tbio
Novelty:  0.00016475
Score:  0.945
Data Source:  STRINGDB
ADCY5
Tchem
Family:  Enzyme
Novelty:  0.00307839
Score:  0.945
Data Source:  STRINGDB
NPS
Tbio
Novelty:  0.00692108
Score:  0.944
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (26)
Adrenoceptors (R-HSA-390696)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 8
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Adrenoceptors
Reactome
Amine ligand-binding receptors
Reactome
Class A/1 (Rhodopsin-like receptors)
Reactome
G alpha (s) signalling events
Reactome
GPCR downstream signalling
Name
Explore in Pharos
Explore in Source
Adrenoceptors
Amine ligand-binding receptors
Class A/1 (Rhodopsin-like receptors)
G alpha (s) signalling events
GPCR downstream signalling
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (31)
Find Similar Targets
Items per page:
10
1 – 10 of 10
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
BHF-UCL
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Physical Interaction (IPI)
BHF-UCL
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Traceable Author Statement (TAS)
ProtInc
Inferred from Electronic Annotation (IEA)
Ensembl
Disease Associations (null)
No disease associations found
GWAS Traits (26)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
high density lipoprotein cholesterol measurement
5
4
5
91
birth weight
6
3
6
89.8
triglyceride measurement
2
2
2
68.1
diastolic blood pressure
2
2
2
62.6
Agents acting on the renin-angiotensin system use measurement
1
1
1
58.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
high density lipoprotein cholesterol measurement
5
91
birth weight
6
89.8
triglyceride measurement
2
68.1
diastolic blood pressure
2
62.6
Agents acting on the renin-angiotensin system use measurement
1
58.4
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
adrenoceptor beta 1
VGNC:3799
466206
Mouse
MGI:87937
11554
Rat
RGD:2059
24925
Dog
adrenoceptor beta 1
VGNC:37676
493972
Cow
adrenoceptor beta 1
VGNC:50130
281604
Species
Name
OMA
EggNOG
Inparanoid
Chimp
adrenoceptor beta 1
Mouse
Rat
Dog
adrenoceptor beta 1
Cow
adrenoceptor beta 1
Publication Statistics
PubMed Score 864.79
PubMed score by year
PubTator Score 1039.85
PubTator score by year
Patents
Patents by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title