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Tbio
MELTF
Melanotransferrin

Protein Summary
Description
Involved in iron cellular uptake. Seems to be internalized and then recycled back to the cell membrane. Binds a single atom of iron per subunit. Could also bind zinc. The protein encoded by this gene is a cell-surface glycoprotein found on melanoma cells. The protein shares sequence similarity and iron-binding properties with members of the transferrin superfamily. The importance of the iron binding function has not yet been identified. This gene resides in the same region of chromosome 3 as members of the transferrin superfamily. Alternative splicing results in two transcript variants. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000296350
  • ENSP00000296350
  • ENSG00000163975
  • ENST00000296351
  • ENSP00000296351

Symbol
  • MAP97
  • MFI2
  • MTf
  • MFI2
  • MTF1
  • CD228
  • MAP97
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0
biological term
0
cell line
0
cell type or tissue
0
cellular component
0


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 121.09   (req: < 5)
Gene RIFs: 17   (req: <= 3)
Antibodies: 307   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 121.09   (req: >= 5)
Gene RIFs: 17   (req: > 3)
Antibodies: 307   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (185)
ICOS
Tbio
Novelty:  0.01378323
p_int:  0.997462923
p_ni:  2.27e-7
p_wrong:  0.002536851
Score:  0.692
Data Source:  BioPlex,STRINGDB
IL6
Tclin
Novelty:  0.00001819
Score:  0.934
Data Source:  STRINGDB
CP
Tbio
Novelty:  0.00103285
Score:  0.93
Data Source:  STRINGDB
APOB
Tchem
Novelty:  0.00008247
Score:  0.925
Data Source:  STRINGDB
ALB
Tchem
Novelty:  0.00000616
Score:  0.922
Data Source:  STRINGDB
CNTN3
Tbio
Novelty:  0.0055725
Score:  0.921
Data Source:  STRINGDB
CNTN5
Tbio
Novelty:  0.00601105
Score:  0.921
Data Source:  STRINGDB
CNTN4
Tbio
Novelty:  0.02483465
Score:  0.921
Data Source:  STRINGDB
APOE
Tbio
Novelty:  0.00005049
Score:  0.916
Data Source:  STRINGDB
AHSG
Tbio
Novelty:  0.00112502
Score:  0.915
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (5)
Metabolism of proteins (R-HSA-392499)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 5
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Metabolism of proteins
Reactome
Post-translational modification: synthesis of GPI-anchored proteins
Reactome
Post-translational protein modification
Reactome
Post-translational protein phosphorylation
Reactome
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
Name
Explore in Pharos
Explore in Source
Metabolism of proteins
Post-translational modification: synthesis of GPI-anchored proteins
Post-translational protein modification
Post-translational protein phosphorylation
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (14)
Find Similar Targets
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Mutant Phenotype (IMP)
UniProtKB
Disease Associations ()
No disease associations found
GWAS Traits (6)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
viral load
1
1
1
68.6
mathematical ability
3
1
3
59.5
self reported educational attainment
1
1
1
55.2
waist-hip ratio
1
1
1
24.5
BMI-adjusted waist-hip ratio
1
1
1
21.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
viral load
1
68.6
mathematical ability
3
59.5
self reported educational attainment
1
55.2
waist-hip ratio
1
24.5
BMI-adjusted waist-hip ratio
1
21.5
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
melanotransferrin
VGNC:7984
100612834
Macaque
melanotransferrin
707618
Mouse
MGI:1353421
30060
Rat
RGD:1308155
288038
Dog
melanotransferrin
VGNC:43155
488035
Species
Name
OMA
EggNOG
Inparanoid
Chimp
melanotransferrin
Macaque
melanotransferrin
Mouse
Rat
Dog
melanotransferrin
Publication Statistics
PubMed Score 121.09
PubMed score by year
PubTator Score 305.84
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title