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Tclin
MET
Hepatocyte growth factor receptor

Protein Summary
Description
Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to hepatocyte growth factor/HGF ligand. Regulates many physiological processes including proliferation, scattering, morphogenesis and survival. Ligand binding at the cell surface induces autophosphorylation of MET on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by ligand, interacts with the PI3-kinase subunit PIK3R1, PLCG1, SRC, GRB2, STAT3 or the adapter GAB1. Recruitment of these downstream effectors by MET leads to the activation of several signaling cascades including the RAS-ERK, PI3 kinase-AKT, or PLCgamma-PKC. The RAS-ERK activation is associated with the morphogenetic effects while PI3K/AKT coordinates prosurvival effects. During embryonic development, MET signaling plays a role in gastrulation, development and migration of muscles and neuronal precursors, angiogenesis and kidney formation. In adults, parti ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000318493
  • ENSP00000317272
  • ENSG00000105976
  • ENST00000397752
  • ENSP00000380860
  • ENST00000436117
  • ENSP00000410980

Symbol
  • HGFR
  • AUTS9
  • RCCP2
  • c-Met
  • DFNB97
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological term
1
protein domain
1
biological process
0.99
hub protein
0.99
molecular function
0.99


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2866.8   (req: < 5)
Gene RIFs: 999   (req: <= 3)
Antibodies: 2650   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2866.8   (req: >= 5)
Gene RIFs: 999   (req: > 3)
Antibodies: 2650   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 37
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 1746
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 6