Tchem PTPRC Receptor-type tyrosine-protein phosphatase C

Protein Summary

Description

Protein tyrosine-protein phosphatase required for T-cell activation through the antigen receptor. Acts as a positive regulator of T-cell coactivation upon binding to DPP4. The first PTPase domain has enzymatic activity, while the second one seems to affect the substrate specificity of the first one. Upon T-cell activation, recruits and dephosphorylates SKAP1 and FYN. Dephosphorylates LYN, and thereby modulates LYN activity (By similarity). (Microbial infection) Acts as a receptor for human cytomegalovirus protein UL11 and mediates binding of UL11 to T-cells, leading to reduced induction of tyrosine phosphorylation of multiple signaling proteins upon T-cell receptor stimulation and impaired T-cell proliferation. The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitosis, and oncogenic transformation. This PTP contains an extracellular domain, a single transmembrane segment and two tandem intracytoplasmic catalytic domains, and thus is classified as a receptor type PTP. This PTP has been shown to be an essential regulator of T- and B-cell antigen receptor signaling. It functions through either direct interaction with components of the antigen receptor complexes, or by activating various Src family kinases required for the antigen receptor signaling. This PTP also suppresses JAK kinases, and thus functions as a regulator of cytokine receptor signaling. Alternatively spliced transcripts variants of this gene, which encode distinct isoforms, have been reported. [provided by RefSeq, Jun 2012]

Uniprot Accession IDs

• P08575
• A0A0A0MT22
• A8K7W6
• Q16614
• Q9H0Y6
• X6R433

Gene Name

• PTPRC

Ensembl ID

• ENST00000348564
• ENSP00000306782
• ENSG00000081237
• ENST00000442510
• ENSP00000411355
• ENST00000573477
• ENSP00000461074
• ENSG00000262418
• ENST00000573679
• ENSP00000458322

Symbol

• CD45
• LCA
• LY5
• B220
• CD45
• L-CA
• T200
• CD45R
• GP180

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
biological process	1
PubMedID	1
protein domain	0.97
gene perturbation	0.85
hub protein	0.79

Protein Classes

PANTHER Classes

Protein / Receptor / Receptor-type Tyrosine-protein Phosphatase C

Protein / Hydrolase / Phosphatase / Protein Phosphatase / Receptor-type Tyrosine-protein Phosphatase C

DTO Classes

Protein / Enzyme / Hydrolase / Phosphatase / Protein Phosphatase / Receptor-type Tyrosine-protein Phosphatase C

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 9320.88   (req: < 5)

Gene RIFs: 225   (req: <= 3)

Antibodies: 0   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 9320.88   (req: >= 5)

Gene RIFs: 225   (req: > 3)

Antibodies: 0   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 74

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 65

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0