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Tchem
PTPRC
Receptor-type tyrosine-protein phosphatase C

Protein Summary
Description
Protein tyrosine-protein phosphatase required for T-cell activation through the antigen receptor. Acts as a positive regulator of T-cell coactivation upon binding to DPP4. The first PTPase domain has enzymatic activity, while the second one seems to affect the substrate specificity of the first one. Upon T-cell activation, recruits and dephosphorylates SKAP1 and FYN. Dephosphorylates LYN, and thereby modulates LYN activity (By similarity). (Microbial infection) Acts as a receptor for human cytomegalovirus protein UL11 and mediates binding of UL11 to T-cells, leading to reduced induction of tyrosine phosphorylation of multiple signaling proteins upon T-cell receptor stimulation and impaired T-cell proliferation. The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitosis, and oncogenic transformation. This PTP contains ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000348564
  • ENSP00000306782
  • ENSG00000081237
  • ENST00000442510
  • ENSP00000411355
  • ENST00000573477
  • ENSP00000461074
  • ENSG00000262418
  • ENST00000573679
  • ENSP00000458322

Symbol
  • CD45
  • LCA
  • LY5
  • B220
  • CD45
  • L-CA
  • T200
  • CD45R
  • GP180
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
1
PubMedID
1
protein domain
0.97
gene perturbation
0.85
hub protein
0.79


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 7782.92   (req: < 5)
Gene RIFs: 187   (req: <= 3)
Antibodies: 0   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 7782.92   (req: >= 5)
Gene RIFs: 187   (req: > 3)
Antibodies: 0   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 74
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 64
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (35)
Items per page:
1 – 5 of 35
GWAS Trait
EFO ID
ENSG ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
lymphocyte count
3
4
6
90.4
lymphocyte count
3
4
6
90.4
myeloid white cell count
1
1
1
78
myeloid white cell count
1
1
1
78
monocyte count
1
4
4
62.7
Items per page:
1 – 5 of 35
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
lymphocyte count
6
90.4
lymphocyte count
6
90.4
myeloid white cell count
1
78
myeloid white cell count
1
78
monocyte count
4
62.7
Protein Data Bank (5)
1 – 5 of 5
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (29)
Adaptive Immune System (R-HSA-1280218)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 10
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Adaptive Immune System
Reactome
Axon guidance
Reactome
Developmental Biology
Reactome
Immune System
Reactome
Innate Immune System
Name
Explore in Pharos
Explore in Source
Adaptive Immune System
Axon guidance
Developmental Biology
Immune System
Innate Immune System
Gene Ontology Terms (87)
Items per page:
10
1 – 9 of 9
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
ARUK-UCL
Inferred from Physical Interaction (IPI)
ARUK-UCL
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Sequence or structural Similarity (ISS)
ARUK-UCL
Traceable Author Statement (TAS)
ARUK-UCL
Traceable Author Statement (TAS)
ARUK-UCL
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Protein-Protein Interactions (717)
1 – 10 of 717
LCK
Tclin
Family: Kinase
Novelty: 0.00058377
Score: 0.994
Data Source: Reactome,STRINGDB
CXCR4
Tclin
Family: GPCR
Novelty: 0.0002811
Score: 0.99
Data Source: STRINGDB
CD79A
Tbio
Novelty: 0.00118942
Score: 0.986
Data Source: STRINGDB
FYN
Tclin
Family: Kinase
Novelty: 0.00072167
Score: 0.983
Data Source: STRINGDB
CD3E
Tclin
Novelty: 0.0053855
Score: 0.982
Data Source: Reactome,STRINGDB
CD4
Tclin
Novelty: 0.00001217
Score: 0.982
Data Source: Reactome,STRINGDB
CD22
Tclin
Novelty: 0.0009372
Score: 0.979
Data Source: STRINGDB
CD247
Tbio
Novelty: 0.00217194
Score: 0.974
Data Source: Reactome,STRINGDB
LYN
Tclin
Family: Kinase
Novelty: 0.00097393
Score: 0.973
Data Source: STRINGDB
CD79B
Tclin
Novelty: 0.00227414
Score: 0.973
Data Source: STRINGDB
Publication Statistics
PubMed Score  7782.92

PubMed score by year
PubTator Score  2832.33

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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