CYC1
Cytochrome c1, heme protein, mitochondrial
Protein Summary
This is the heme-containing component of the cytochrome b-c1 complex, which accepts electrons from Rieske protein and transfers electrons to cytochrome c in the mitochondrial respiratory chain. This gene encodes a subunit of the cytochrome bc1 complex, which plays an important role in the mitochondrial respiratory chain by transferring electrons from the Rieske iron-sulfur protein to cytochrome c. Mutations in this gene may cause mitochondrial complex III deficiency, nuclear type 6. [provided by RefSeq, Dec 2013]
- ENST00000318911
- ENSP00000317159
- ENSG00000179091
- UQCR4
- MC3DN6
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
disease perturbation | 1 | ||
co-expressed gene | 0.99 | ||
kinase perturbation | 0.91 | ||
virus perturbation | 0.83 | ||
transcription factor perturbation | 0.8 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 59.05 (req: < 5)
Gene RIFs: 14 (req: <= 3)
Antibodies: 371 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 59.05 (req: >= 5)
Gene RIFs: 14 (req: > 3)
Antibodies: 371 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 7
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 1
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
Related Tools
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
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GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (1)
Active Ligands (0)
Protein-Protein Interactions (305)
HCCS
Family: Enzyme
Novelty: 0.0022585
p_int: 0.999895592
p_ni: 0.000104408
Score: 0.813
Data Source: BioPlex,STRINGDB
UQCRH
Novelty: 0.04494433
p_int: 0.987828044
p_ni: 0.012171956
Score: 0.999
Data Source: BioPlex,STRINGDB
PTGES2
Family: Enzyme
Novelty: 0.01415352
p_int: 0.96599556
p_ni: 0.03400444
Score: 0.378
Data Source: BioPlex,STRINGDB
PEX19
Novelty: 0.00605342
p_int: 0.956886723
p_ni: 0.043113277
Score: 0.277
Data Source: BioPlex,STRINGDB
UQCRB
Novelty: 0.02933046
p_int: 0.936677682
p_ni: 0.063322318
Score: 0.999
Data Source: BioPlex,STRINGDB
SCYL3
Family: Kinase
Novelty: 0.13735583
p_int: 0.930026635
p_ni: 0.069973365
Data Source: BioPlex
Nearest Tclin Targets
Pathways (24)
Reactome (6)
KEGG (8)
PathwayCommons (2)
WikiPathways (8)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Metabolism | ||||
Reactome | Mitochondrial protein import | ||||
Reactome | Protein localization | ||||
Reactome | Respiratory electron transport | ||||
Reactome | Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Metabolism | ||||
Mitochondrial protein import | ||||
Protein localization | ||||
Respiratory electron transport | ||||
Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. | ||||
Viral Interactions (0)
Gene Ontology Terms (13)
Functions (4)
Components (6)
Processes (3)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Traceable Author Statement (TAS) | ProtInc | |||
Inferred from Electronic Annotation (IEA) | InterPro | |||
Inferred from Electronic Annotation (IEA) | UniProtKB-KW | |||
Disease Associations ()
GWAS Traits (18)
Items per page:
1 – 5 of 18
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
serum metabolite measurement | 1 | 2 | 2 | 93 | |||||
blood metabolite measurement | 1 | 2 | 2 | 89.7 | |||||
metabolite measurement | 1 | 1 | 1 | 85.4 | |||||
eosinophil count | 3 | 1 | 3 | 82.6 | |||||
eosinophil percentage of leukocytes | 2 | 1 | 2 | 81.7 | |||||
Items per page:
1 – 5 of 18
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
serum metabolite measurement | 2 | 93 | |||||
blood metabolite measurement | 2 | 89.7 | |||||
metabolite measurement | 1 | 85.4 | |||||
eosinophil count | 3 | 82.6 | |||||
eosinophil percentage of leukocytes | 2 | 81.7 | |||||
Find similar targets by:
IDG Resources
Orthologs (11)
1 – 5 of 11
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | cytochrome c1 | VGNC:6683 | 472893 | |||||
Macaque | cytochrome c-1 | 700518 | ||||||
Mouse | MGI:1913695 | 66445 | ||||||
Dog | cytochrome c1 | VGNC:50287 | 475121 | |||||
Horse | cytochrome c1 | VGNC:49118 | 100146668 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | cytochrome c1 | |||||
Macaque | cytochrome c-1 | |||||
Mouse | ||||||
Dog | cytochrome c1 | |||||
Horse | cytochrome c1 | |||||
Publication Statistics
PubMed Score 59.05
PubMed score by year
PubTator Score 54.50
PubTator score by year
Related Publications
Text Mined References (31)
GeneRif Annotations (14)
Items per page:
0 of 0
PMID | Year | Title |
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