Tchem CYC1 Cytochrome c1, heme protein, mitochondrial

Protein Summary

Description

This is the heme-containing component of the cytochrome b-c1 complex, which accepts electrons from Rieske protein and transfers electrons to cytochrome c in the mitochondrial respiratory chain. This gene encodes a subunit of the cytochrome bc1 complex, which plays an important role in the mitochondrial respiratory chain by transferring electrons from the Rieske iron-sulfur protein to cytochrome c. Mutations in this gene may cause mitochondrial complex III deficiency, nuclear type 6. [provided by RefSeq, Dec 2013]

Uniprot Accession IDs

• P08574
• Q5U062
• Q6FHS7

Gene Name

• CYC1

Ensembl ID

• ENST00000318911
• ENSP00000317159
• ENSG00000179091

Symbol

• UQCR4
• MC3DN6

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
disease perturbation	1
co-expressed gene	0.99
kinase perturbation	0.91
virus perturbation	0.83
transcription factor perturbation	0.8

Related Tools

Target Illumination GWAS Analytics (TIGA)

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GENEVA

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GlyGen

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

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IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 59.05   (req: < 5)

Gene RIFs: 14   (req: <= 3)

Antibodies: 371   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 59.05   (req: >= 5)

Gene RIFs: 14   (req: > 3)

Antibodies: 371   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 1

Approved Drugs (1)

Explore Approved Drugs

1 – 1 of 1

gilteritinib

CYC1Tchem

Kd : 6.7

GWAS Traits (18)

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GWAS Trait	EFO ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
serum metabolite measurement	EFO_0005653	1	2	2		93
blood metabolite measurement	EFO_0005664	1	2	2		89.7
metabolite measurement	EFO_0004725	1	1	1		85.4
eosinophil count	EFO_0004842	3	1	3		82.6
eosinophil percentage of leukocytes	EFO_0007991	2	1	2		81.7

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GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
serum metabolite measurement	EFO_0005653	2		93
blood metabolite measurement	EFO_0005664	2		89.7
metabolite measurement	EFO_0004725	1		85.4
eosinophil count	EFO_0004842	3		82.6
eosinophil percentage of leukocytes	EFO_0007991	2		81.7

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Orthologs (11)

1 – 5 of 11

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Chimp	cytochrome c1	VGNC:6683	472893
Macaque	cytochrome c-1		700518
Mouse	cytochrome c-1	MGI:1913695	66445
Dog	cytochrome c1	VGNC:50287	475121
Horse	cytochrome c1	VGNC:49118	100146668

Species	Name	OMA	EggNOG	Inparanoid
Chimp	cytochrome c1
Macaque	cytochrome c-1
Mouse	cytochrome c-1
Dog	cytochrome c1
Horse	cytochrome c1

Protein Structure (3 Structures, 1 AlphaFold Model)

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Representation

  axes   backbone   ball+stick   cartoon   rocket   rope   spacefill

Color Scheme

  target   atomindex   bfactor   chainname   electrostatic   element   hydrophobicity   resname   sstruc

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P08574-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 3 of 3

PDB Structure Id	Ligand	Method	Resolution (Å)	Residues	Fraction of Total Protein	Pub Year	Title

PDB Structure Id	Fraction of Total Protein	Resolution	Pub Year

Pathways (24)

Reactome (6)

KEGG (8)

PathwayCommons (2)

WikiPathways (8)

Metabolism (R-HSA-1430728)

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Data Source	Name	Explore in Pharos	Explore in Source
Reactome	Metabolism	2112 targets	R-HSA-1430728
Reactome	Mitochondrial protein import	65 targets	R-HSA-1268020
Reactome	Protein localization	165 targets	R-HSA-9609507
Reactome	Respiratory electron transport	101 targets	R-HSA-611105
Reactome	Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.	123 targets	R-HSA-163200

Name	Explore in Pharos	Explore in Source
Metabolism	2112 targets	R-HSA-1430728
Mitochondrial protein import	65 targets	R-HSA-1268020
Protein localization	165 targets	R-HSA-9609507
Respiratory electron transport	101 targets	R-HSA-611105
Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.	123 targets	R-HSA-163200

Gene Ontology Terms (13)

Functions (4)

Components (6)

Processes (3)

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1 – 4 of 4

GO Term	Evidence	Assigned by
electron transporter, transferring electrons within CoQH2-cytochrome c reductase complex activity	Inferred from Biological aspect of Ancestor (IBA)	GO_Central
electron transporter, transferring electrons from CoQH2-cytochrome c reductase complex and cytochrome c oxidase complex activity	Traceable Author Statement (TAS)	ProtInc
heme binding	Inferred from Electronic Annotation (IEA)	InterPro
metal ion binding	Inferred from Electronic Annotation (IEA)	UniProtKB-KW

Protein-Protein Interactions (305)

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1 – 10 of 305

• See Interactions on String-DB

HCCS

Tbio

Family:  Enzyme

Novelty:  0.0022585

p_int:  0.999895592

p_ni:  0.000104408

Score:  0.813

Data Source:  BioPlex,STRINGDB

UQCRH

Tbio

Novelty:  0.04494433

p_int:  0.987828044

p_ni:  0.012171956

Score:  0.999

Data Source:  BioPlex,STRINGDB

PTGES2

Tchem

Family:  Enzyme

Novelty:  0.01415352

p_int:  0.96599556

p_ni:  0.03400444

Score:  0.378

Data Source:  BioPlex,STRINGDB

PEX19

Tbio

Novelty:  0.00605342

p_int:  0.956886723

p_ni:  0.043113277

Score:  0.277

Data Source:  BioPlex,STRINGDB

UQCRB

Tbio

Novelty:  0.02933046

p_int:  0.936677682

p_ni:  0.063322318

Score:  0.999

Data Source:  BioPlex,STRINGDB

SCYL3

Tbio

Family:  Kinase

Novelty:  0.13735583

p_int:  0.930026635

p_ni:  0.069973365

Data Source:  BioPlex

MT-CYB

Tbio

Novelty:  0.00012093

Score:  0.999

Data Source:  STRINGDB

UQCRC2

Tbio

Family:  Enzyme

Novelty:  0.01584406

Score:  0.999

Data Source:  STRINGDB

UQCRQ

Tbio

Novelty:  0.04392627

Score:  0.999

Data Source:  STRINGDB

UQCR10

Tbio

Novelty:  0.04536078

Score:  0.999

Data Source:  STRINGDB

Publication Statistics

PubMed Score  59.05

PubMed score by year

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PubTator Score  54.5

PubTator score by year

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Amino Acid Sequence

Residue Counts

Protein Sequence

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UniProt Keyword Find Similar Targets

No Header	No Header
3D-structure
Complete proteome
Disease mutation
Electron transport
Heme
Iron
Membrane
Metal-binding
Mitochondrion
Mitochondrion inner membrane

GWAS Trait Find Similar Targets

No Header	No Header
asthma
bipolar I disorder
blood metabolite measurement
BMI-adjusted waist circumference
creatinine measurement
eosinophil count
eosinophil percentage of granulocytes
eosinophil percentage of leukocytes
fibrinogen measurement
glomerular filtration rate