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Tbio
CD14
Monocyte differentiation antigen CD14

Protein Summary
Description
Coreceptor for bacterial lipopolysaccharide (PubMed:1698311, PubMed:23264655). In concert with LBP, binds to monomeric lipopolysaccharide and delivers it to the LY96/TLR4 complex, thereby mediating the innate immune response to bacterial lipopolysaccharide (LPS) (PubMed:20133493, PubMed:23264655). Acts via MyD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response (PubMed:8612135). Acts as a coreceptor for TLR2:TLR6 heterodimer in response to diacylated lipopeptides and for TLR2:TLR1 heterodimer in response to triacylated lipopeptides, these clusters trigger signaling from the cell surface and subsequently are targeted to the Golgi in a lipid-raft dependent pathway (PubMed:16880211). Binds electronegative LDL (LDL(-)) and mediates the cytokine release induced by LDL(-) (PubMed:23880187). The protein encoded by this gene is a surface antigen that is preferentially expressed on monocytes/macrophages. It cooperates with other proteins to med ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000302014
  • ENSP00000304236
  • ENSG00000170458
  • ENST00000401743
  • ENSP00000385519
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological term
1
disease
0.89
chemical
0.86
gene perturbation
0.85
cellular component
0.82


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 124.47   (req: < 5)
Gene RIFs: 511   (req: <= 3)
Antibodies: 3205   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 124.47   (req: >= 5)
Gene RIFs: 511   (req: > 3)
Antibodies: 3205   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 41
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
inflammatory biomarker measurement
1
1
0
125.7
2.9
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
inflammatory biomarker measurement
0
125.7
2.9
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
CD14 molecule
VGNC:3938
462118
Macaque
CD14 molecule
697482
Mouse
MGI:88318
12475
Rat
RGD:620588
60350
Horse
CD14 molecule
VGNC:16245
100630219
Species
Name
OMA
EggNOG
Inparanoid
Chimp
CD14 molecule
Macaque
CD14 molecule
Mouse
Rat
Horse
CD14 molecule
Protein Structure (1 Structure, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P08571-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (99)
Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon (R-HSA-936964)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 35
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon
Reactome
Adaptive Immune System
Reactome
Antigen processing-Cross presentation
Reactome
Apoptosis
Reactome
Caspase activation via Death Receptors in the presence of ligand
Name
Explore in Pharos
Explore in Source
Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon
Adaptive Immune System
Antigen processing-Cross presentation
Apoptosis
Caspase activation via Death Receptors in the presence of ligand
Protein-Protein Interactions (177)
1 – 10 of 177
MTG2
Tbio
Family: Enzyme
Novelty: 0.06104792
p_int: 0.999929337
p_ni: 0.000070657
p_wrong: 6e-9
Data Source: BioPlex
DIS3
Tbio
Family: Enzyme
Novelty: 0.00961238
p_int: 0.996901173
p_ni: 0.003098827
Data Source: BioPlex
LAMB1
Tbio
Novelty: 0.0104285
p_int: 0.952840251
p_ni: 0.047159749
Data Source: BioPlex
HLA-DQA1
Tbio
Novelty: 0.00077488
p_int: 0.923122317
p_ni: 0.00011445
p_wrong: 0.076763233
Data Source: BioPlex
MAN2B1
Tchem
Family: Enzyme
Novelty: 0.0051017
p_int: 0.89846661
p_ni: 0.10153339
Data Source: BioPlex
BCHE
Tclin
Family: Enzyme
Novelty: 0.00031267
p_int: 0.892001322
p_ni: 0.105919796
p_wrong: 0.002078881
Data Source: BioPlex
GALNS
Tbio
Family: Enzyme
Novelty: 0.00510529
p_int: 0.883876906
p_ni: 0.116123084
p_wrong: 1e-8
Data Source: BioPlex
PTCD2
Tdark
Novelty: 0.23529342
p_int: 0.837322817
p_ni: 0.153756011
p_wrong: 0.008921172
Data Source: BioPlex
INTS7
Tdark
Novelty: 0.04592325
p_int: 0.79278441
p_ni: 0.207215589
Data Source: BioPlex
CERCAM
Tdark
Family: Enzyme
Novelty: 0.33392502
p_int: 0.791321907
p_ni: 0.208678093
Data Source: BioPlex
Publication Statistics
PubMed Score  124.47

PubMed score by year
PubTator Score  3290.22

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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