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Tbio
PLEK
Pleckstrin

IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 867.03   (req: < 5)
Gene RIFs: 12   (req: <= 3)
Antibodies: 406   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 867.03   (req: >= 5)
Gene RIFs: 12   (req: > 3)
Antibodies: 406   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 27
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (451)
WDR75
Tbio
Novelty:  0.09443914
p_int:  0.883803403
p_ni:  0.116196583
p_wrong:  1.4e-8
Score:  0.369
Data Source:  BioPlex,STRINGDB
MCF2
Tbio
Novelty:  0.00345951
Score:  0.874
Data Source:  STRINGDB
AKT1
Tchem
Family:  Kinase
Novelty:  0.00003185
Score:  0.873
Data Source:  STRINGDB
LCP2
Tbio
Novelty:  0.00512968
Score:  0.871
Data Source:  STRINGDB
BTK
Tclin
Family:  Kinase
Novelty:  0.00050747
Score:  0.87
Data Source:  STRINGDB
ITGB2
Tclin
Novelty:  0.00185859
Score:  0.84
Data Source:  STRINGDB
LAPTM5
Tbio
Novelty:  0.06809459
Score:  0.803
Data Source:  STRINGDB
SERPINA4
Tbio
Novelty:  0.00483207
Score:  0.795
Data Source:  STRINGDB
PTPRC
Tchem
Family:  Enzyme
Novelty:  0.00012027
Score:  0.791
Data Source:  STRINGDB
FYB1
Tbio
Novelty:  0.00247573
Score:  0.79
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (7)
Hemostasis (R-HSA-109582)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Hemostasis
Reactome
Platelet activation, signaling and aggregation
Reactome
Platelet degranulation
Reactome
Response to elevated platelet cytosolic Ca2+
Name
Explore in Pharos
Explore in Source
Hemostasis
Platelet activation, signaling and aggregation
Platelet degranulation
Response to elevated platelet cytosolic Ca2+
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (33)
Find Similar Targets
Items per page:
10
1 – 4 of 4
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Sequence Model (ISM)
NTNU_SB
Disease Associations ()
No disease associations found
GWAS Traits (19)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
lymphocyte count
3
1
3
81.1
platelet crit
2
1
2
78.4
3
3
0
1.1
77.7
mean platelet volume
2
1
2
77.4
myeloid white cell count
1
1
1
64
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
lymphocyte count
3
81.1
platelet crit
2
78.4
0
1.1
77.7
mean platelet volume
2
77.4
myeloid white cell count
1
64
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
pleckstrin
VGNC:338
459292
Macaque
pleckstrin
698949
Mouse
MGI:1860485
56193
Rat
RGD:1308269
364206
Dog
pleckstrin
VGNC:44666
442956
Species
Name
OMA
EggNOG
Inparanoid
Chimp
pleckstrin
Macaque
pleckstrin
Mouse
Rat
Dog
pleckstrin
Publication Statistics
PubMed Score 867.03
PubMed score by year
PubTator Score 455.00
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title