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Tbio
PLEK
Pleckstrin

Related Tools
Target Illumination GWAS Analytics (TIGA)
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ARCHS4
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IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 854.16   (req: < 5)
Gene RIFs: 12   (req: <= 3)
Antibodies: 406   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 854.16   (req: >= 5)
Gene RIFs: 12   (req: > 3)
Antibodies: 406   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 27
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (12)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
lymphocyte count
3
1
3
81.3
mean platelet volume
2
1
2
77.9
2
2
0
1.1
75
venous thromboembolism
2
1
1
1.1
71.5
myeloid white cell count
1
1
1
66.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
lymphocyte count
3
81.3
mean platelet volume
2
77.9
0
1.1
75
venous thromboembolism
1
1.1
71.5
myeloid white cell count
1
66.4
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
pleckstrin
VGNC:338
459292
Macaque
pleckstrin
698949
Mouse
MGI:1860485
56193
Rat
RGD:1308269
364206
Dog
pleckstrin
VGNC:44666
442956
Species
Name
OMA
EggNOG
Inparanoid
Chimp
pleckstrin
Macaque
pleckstrin
Mouse
Rat
Dog
pleckstrin
Protein Structure (8 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P08567-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 5 of 8
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (7)
Hemostasis (R-HSA-109582)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Hemostasis
Reactome
Platelet activation, signaling and aggregation
Reactome
Platelet degranulation
Reactome
Response to elevated platelet cytosolic Ca2+
Name
Explore in Pharos
Explore in Source
Hemostasis
Platelet activation, signaling and aggregation
Platelet degranulation
Response to elevated platelet cytosolic Ca2+
Protein-Protein Interactions (451)
1 – 10 of 451
WDR75
Tbio
Novelty: 0.09443914
p_int: 0.883803403
p_ni: 0.116196583
p_wrong: 1.4e-8
Score: 0.369
Data Source: BioPlex,STRINGDB
MCF2
Tbio
Novelty: 0.00345951
Score: 0.874
Data Source: STRINGDB
AKT1
Tchem
Family: Kinase
Novelty: 0.00003185
Score: 0.873
Data Source: STRINGDB
LCP2
Tbio
Novelty: 0.00512968
Score: 0.871
Data Source: STRINGDB
BTK
Tclin
Family: Kinase
Novelty: 0.00050747
Score: 0.87
Data Source: STRINGDB
ITGB2
Tclin
Novelty: 0.00185859
Score: 0.84
Data Source: STRINGDB
LAPTM5
Tbio
Novelty: 0.06809459
Score: 0.803
Data Source: STRINGDB
SERPINA4
Tbio
Novelty: 0.00483207
Score: 0.795
Data Source: STRINGDB
PTPRC
Tchem
Family: Enzyme
Novelty: 0.00012027
Score: 0.791
Data Source: STRINGDB
FYB1
Tbio
Novelty: 0.00247573
Score: 0.79
Data Source: STRINGDB
Publication Statistics
PubMed Score  854.16

PubMed score by year
PubTator Score  455

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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