Tbio PDHA1 Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial

Protein Summary

Description

The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2), and thereby links the glycolytic pathway to the tricarboxylic cycle. The pyruvate dehydrogenase (PDH) complex is a nuclear-encoded mitochondrial multienzyme complex that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2), and provides the primary link between glycolysis and the tricarboxylic acid (TCA) cycle. The PDH complex is composed of multiple copies of three enzymatic components: pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydrogenase (E3). The E1 enzyme is a heterotetramer of two alpha and two beta subunits. This gene encodes the E1 alpha 1 subunit containing the E1 active site, and plays a key role in the function of the PDH complex. Mutations in this gene are associated with pyruvate dehydrogenase E1-alpha deficiency and X-linked Leigh syndrome. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Mar 2010]

Uniprot Accession IDs

• P08559
• A5YVE9
• B2R5P7
• B7Z3T7
• B7Z3X5
• Q53H41
• Q5JPT8
• Q9NP12
• Q9UBJ8
• Q9UBU0
• Q9UNG4
• Q9UNG5

Gene Name

• PDHA1

Ensembl ID

• ENST00000379806
• ENSP00000369134
• ENSG00000131828
• ENST00000422285
• ENSP00000394382
• ENST00000540249
• ENSP00000440761
• ENST00000545074
• ENSP00000438550

Symbol

• PHE1A
• PDHA
• PDHAD
• PHE1A
• PDHCE1A

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
disease perturbation	1
kinase perturbation	1
transcription factor perturbation	0.94
histone modification site profile	0.88
interacting protein	0.86

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 303.89   (req: < 5)

Gene RIFs: 49   (req: <= 3)

Antibodies: 601   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 303.89   (req: >= 5)

Gene RIFs: 49   (req: > 3)

Antibodies: 601   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0