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Tbio
LPA
Apolipoprotein(a)

Protein Summary
Description
Apo(a) is the main constituent of lipoprotein(a) (Lp(a)). It has serine proteinase activity and is able of autoproteolysis. Inhibits tissue-type plasminogen activator 1. Lp(a) may be a ligand for megalin/Gp 330. The protein encoded by this gene is a serine proteinase that inhibits the activity of tissue-type plasminogen activator I. The encoded protein constitutes a substantial portion of lipoprotein(a) and is proteolytically cleaved, resulting in fragments that attach to atherosclerotic lesions and promote thrombogenesis. Elevated plasma levels of this protein are linked to atherosclerosis. Depending on the individual, the encoded protein contains 2-43 copies of kringle-type domains. The allele represented here contains 15 copies of the kringle-type repeats and corresponds to that found in the reference genome sequence. [provided by RefSeq, Dec 2009]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000316300
  • ENSP00000321334
  • ENSG00000198670
  • ENST00000447678
  • ENSP00000395608

Symbol
  • LP
  • AK38
  • APOA
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological term
0.95
trait
0.86
disease
0.75
phenotype
0.67
cellular component
0.51


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1757.97   (req: < 5)
Gene RIFs: 281   (req: <= 3)
Antibodies: 294   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1757.97   (req: >= 5)
Gene RIFs: 281   (req: > 3)
Antibodies: 294   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (30)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
lipoprotein A measurement
5
27
5
7.2
100
apolipoprotein A 1 measurement
3
15
2
9.1
99.8
low density lipoprotein cholesterol measurement
8
3
10
8.1
99.8
10
9
9
1.4
99.5
response to statin
5
1
4
6.8
97.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
lipoprotein A measurement
5
7.2
100
apolipoprotein A 1 measurement
2
9.1
99.8
low density lipoprotein cholesterol measurement
10
8.1
99.8
9
1.4
99.5
response to statin
4
6.8
97.6
Protein Data Bank (12)
1 – 5 of 12
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (7)
LDL remodeling (R-HSA-8964041)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
LDL remodeling
Reactome
Plasma lipoprotein assembly, remodeling, and clearance
Reactome
Plasma lipoprotein remodeling
Reactome
Transport of small molecules
Name
Explore in Pharos
Explore in Source
LDL remodeling
Plasma lipoprotein assembly, remodeling, and clearance
Plasma lipoprotein remodeling
Transport of small molecules
Protein-Protein Interactions (143)
1 – 10 of 143
APOB
Tchem
Novelty: 0.00008247
Score: 0.994
Data Source: STRINGDB
APOA1
Tbio
Novelty: 0.0001216
Score: 0.985
Data Source: STRINGDB
APOA2
Tbio
Novelty: 0.00117627
Score: 0.981
Data Source: STRINGDB
LCAT
Tbio
Family: Enzyme
Novelty: 0.00307544
Score: 0.969
Data Source: STRINGDB
APOC3
Tclin
Novelty: 0.0009635
Score: 0.967
Data Source: STRINGDB
APOE
Tbio
Novelty: 0.00005049
Score: 0.961
Data Source: STRINGDB
CETP
Tchem
Novelty: 0.00051779
Score: 0.96
Data Source: STRINGDB
APOM
Tbio
Novelty: 0.00505937
Score: 0.96
Data Source: STRINGDB
APOA4
Tbio
Novelty: 0.00305835
Score: 0.953
Data Source: STRINGDB
APOC2
Tbio
Novelty: 0.0015496
Score: 0.952
Data Source: STRINGDB
Publication Statistics
PubMed Score  1757.97

PubMed score by year
PubTator Score  3122.28

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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