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Tclin
ITGA2B
Integrin alpha-IIb

Protein Summary
Description
Integrin alpha-IIb/beta-3 is a receptor for fibronectin, fibrinogen, plasminogen, prothrombin, thrombospondin and vitronectin. It recognizes the sequence R-G-D in a wide array of ligands. It recognizes the sequence H-H-L-G-G-G-A-K-Q-A-G-D-V in fibrinogen gamma chain. Following activation integrin alpha-IIb/beta-3 brings about platelet/platelet interaction through binding of soluble fibrinogen. This step leads to rapid platelet aggregation which physically plugs ruptured endothelial cell surface. This gene encodes a member of the integrin alpha chain family of proteins. The encoded preproprotein is proteolytically processed to generate light and heavy chains that associate through disulfide linkages to form a subunit of the alpha-IIb/beta-3 integrin cell adhesion receptor. This receptor plays a crucial role in the blood coagulation system, by mediating platelet aggregation. Mutations in this gene are associated with platelet-type bleeding disorders, which are characterized by a failure ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000262407
  • ENSP00000262407
  • ENSG00000005961

Symbol
  • GP2B
  • ITGAB
  • GT
  • GTA
  • CD41
  • GP2B
  • HPA3
  • CD41B
  • GPIIb
  • BDPLT2
  • BDPLT16
  • PPP1R93
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological term
1
protein complex
0.94
disease
0.82
cellular component
0.74
protein domain
0.73


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 4273.07   (req: < 5)
Gene RIFs: 259   (req: <= 3)
Antibodies: 1685   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 4273.07   (req: >= 5)
Gene RIFs: 259   (req: > 3)
Antibodies: 1685   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 11
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 3
GWAS Traits (3)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean platelet volume
2
2
3
73.6
platelet count
2
1
2
63
platelet crit
1
1
1
23.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean platelet volume
3
73.6
platelet count
2
63
platelet crit
1
23.7
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
integrin subunit alpha 2b
714955
Mouse
MGI:96601
16399
Rat
RGD:1596428
685269
Dog
integrin subunit alpha 2b
VGNC:42124
403789
Horse
integrin subunit alpha 2b [Source:HGNC Symbol;Acc:HGNC:6138]
Species
Name
OMA
EggNOG
Inparanoid
Macaque
integrin subunit alpha 2b
Mouse
Rat
Dog
integrin subunit alpha 2b
Horse
integrin subunit alpha 2b [Source:HGNC Symbol;Acc:HGNC:6138]
Protein Data Bank (42)
1 – 5 of 42
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (70)
Axon guidance (R-HSA-422475)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 39
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Axon guidance
Reactome
Cytokine Signaling in Immune system
Reactome
Developmental Biology
Reactome
Disease
Reactome
Diseases of signal transduction
Name
Explore in Pharos
Explore in Source
Axon guidance
Cytokine Signaling in Immune system
Developmental Biology
Disease
Diseases of signal transduction
Gene Ontology Terms (19)
Items per page:
10
1 – 4 of 4
GO Term
Evidence
Assigned by
Inferred from Physical Interaction (IPI)
IntAct
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (349)
1 – 10 of 349
ITGB3
Tclin
Novelty: 0.00067255
Score: 0.999
Data Source: Reactome,STRINGDB
VWF
Tbio
Novelty: 0.00009007
Score: 0.989
Data Source: Reactome,STRINGDB
FLNA
Tbio
Novelty: 0.00156479
Score: 0.988
Data Source: STRINGDB
FN1
Tchem
Novelty: 0.00003647
Score: 0.974
Data Source: Reactome,STRINGDB
ITGB1
Tclin
Novelty: 0.00055626
Score: 0.971
Data Source: STRINGDB
GATA1
Tbio
Family: TF
Novelty: 0.00077901
Score: 0.968
Data Source: STRINGDB
TLN1
Tbio
Novelty: 0.00803981
Score: 0.958
Data Source: Reactome,STRINGDB
VTN
Tbio
Family: TF
Novelty: 0.00046861
Score: 0.956
Data Source: Reactome,STRINGDB
LCK
Tclin
Family: Kinase
Novelty: 0.00058377
Score: 0.949
Data Source: STRINGDB
FGA
Tbio
Novelty: 0.00107227
Score: 0.947
Data Source: Reactome,STRINGDB
Publication Statistics
PubMed Score  4273.07

PubMed score by year
PubTator Score  2643.78

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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