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Tclin
MME
Neprilysin

Protein Summary
Description
Thermolysin-like specificity, but is almost confined on acting on polypeptides of up to 30 amino acids (PubMed:15283675, PubMed:8168535). Biologically important in the destruction of opioid peptides such as Met- and Leu-enkephalins by cleavage of a Gly-Phe bond (PubMed:17101991). Able to cleave angiotensin-1, angiotensin-2 and angiotensin 1-9 (PubMed:15283675). Involved in the degradation of atrial natriuretic factor (ANF) (PubMed:2531377, PubMed:2972276). Displays UV-inducible elastase activity toward skin preelastic and elastic fibers (PubMed:20876573). The protein encoded by this gene is a type II transmembrane glycoprotein and a common acute lymphocytic leukemia antigen that is an important cell surface marker in the diagnosis of human acute lymphocytic leukemia (ALL). The encoded protein is present on leukemic cells of pre-B phenotype, which represent 85% of cases of ALL. This protein is not restricted to leukemic cells, however, and is found on a variety of normal tissues. The pr ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000360490
  • ENSP00000353679
  • ENSG00000196549
  • ENST00000460393
  • ENSP00000418525
  • ENST00000462745
  • ENSP00000419653
  • ENST00000492661
  • ENSP00000420389
  • ENST00000493237
  • ENSP00000417079
  • ENST00000615825
  • ENSP00000478173

Symbol
  • EPN
  • NEP
  • SFE
  • CD10
  • CALLA
  • CMT2T
  • SCA43
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
PubMedID
0.95
cellular component
0.8
disease
0.78
protein domain
0.73
hub protein
0.71


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 5215.68   (req: < 5)
Gene RIFs: 237   (req: <= 3)
Antibodies: 2082   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 5215.68   (req: >= 5)
Gene RIFs: 237   (req: > 3)
Antibodies: 2082   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 19
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 302
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 2
Approved Drugs (2)
1 – 2 of 2
racecadotril
chemical structure image
sacubitril
chemical structure image
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
testosterone measurement
2
1
2
75.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
testosterone measurement
2
75.6
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
membrane metalloendopeptidase
VGNC:14231
460792
Macaque
membrane metalloendopeptidase
707667
Mouse
MGI:97004
17380
Rat
RGD:3098
24590
Dog
membrane metalloendopeptidase
VGNC:43271
477120
Species
Name
OMA
EggNOG
Inparanoid
Chimp
membrane metalloendopeptidase
Macaque
membrane metalloendopeptidase
Mouse
Rat
Dog
membrane metalloendopeptidase
Protein Data Bank (12)
1 – 5 of 12
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (12)
Immune System (R-HSA-168256)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 6
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Immune System
Reactome
Innate Immune System
Reactome
Metabolism of Angiotensinogen to Angiotensins
Reactome
Metabolism of proteins
Reactome
Neutrophil degranulation
Name
Explore in Pharos
Explore in Source
Immune System
Innate Immune System
Metabolism of Angiotensinogen to Angiotensins
Metabolism of proteins
Neutrophil degranulation
Gene Ontology Terms (32)
Items per page:
10
1 – 6 of 6
GO Term
Evidence
Assigned by
Inferred from Experiment (EXP)
Reactome
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Protein-Protein Interactions (261)
1 – 10 of 261
HLA-A
Tbio
Novelty: 0.00270731
p_int: 0.999379371
p_ni: 0.000620629
Score: 0.364
Data Source: BioPlex,STRINGDB
GLT8D2
Tbio
Family: Enzyme
Novelty: 0.79488367
p_int: 0.995822912
p_ni: 0.000605202
p_wrong: 0.003571886
Score: 0.175
Data Source: BioPlex,STRINGDB
LEMD3
Tbio
Novelty: 0.00579701
p_int: 0.994968151
p_ni: 0.005031849
Data Source: BioPlex
PXMP2
Tbio
Novelty: 0.24472872
p_int: 0.990695666
p_ni: 0.009304332
p_wrong: 2e-9
Data Source: BioPlex
POMGNT1
Tbio
Family: Enzyme
Novelty: 0.00755927
p_int: 0.981334051
p_ni: 0.018665949
Score: 0.185
Data Source: BioPlex,STRINGDB
SLC10A7
Tbio
Family: Transporter
Novelty: 0.15556211
p_int: 0.979076437
p_ni: 0.020015103
p_wrong: 0.00090846
Data Source: BioPlex
STARD3
Tbio
Novelty: 0.01540936
p_int: 0.976399229
p_ni: 0.023600544
p_wrong: 2.27e-7
Score: 0.152
Data Source: BioPlex,STRINGDB
MANEAL
Tdark
Family: Enzyme
Novelty: 0.71535497
p_int: 0.96881441
p_ni: 0.03118559
Data Source: BioPlex
TENM3
Tbio
Novelty: 0.0251948
p_int: 0.968742657
p_ni: 0.030880987
p_wrong: 0.000376356
Score: 0.182
Data Source: BioPlex,STRINGDB
TMEM223
Tdark
Novelty: 0.89146194
p_int: 0.949647882
p_ni: 0.050341454
p_wrong: 0.000010663
Data Source: BioPlex
Publication Statistics
PubMed Score  5215.68

PubMed score by year
PubTator Score  2796.3

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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