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Tbio
SOD3
Extracellular superoxide dismutase [Cu-Zn]

Protein Classes
Protein Summary
Description
Protect the extracellular space from toxic effect of reactive oxygen intermediates by converting superoxide radicals into hydrogen peroxide and oxygen. This gene encodes a member of the superoxide dismutase (SOD) protein family. SODs are antioxidant enzymes that catalyze the conversion of superoxide radicals into hydrogen peroxide and oxygen, which may protect the brain, lungs, and other tissues from oxidative stress. Proteolytic processing of the encoded protein results in the formation of two distinct homotetramers that differ in their ability to interact with the extracellular matrix (ECM). Homotetramers consisting of the intact protein, or type C subunit, exhibit high affinity for heparin and are anchored to the ECM. Homotetramers consisting of a proteolytically cleaved form of the protein, or type A subunit, exhibit low affinity for heparin and do not interact with the ECM. A mutation in this gene may be associated with increased heart disease risk. [provided by RefSeq, Oct 2015]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000382120
  • ENSP00000371554
  • ENSG00000109610

Symbol
  • EC-SOD
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological term
0.83
disease perturbation
0.83
disease
0.74
molecular function
0.67
chemical
0.6


Related Tools
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 709.06   (req: < 5)
Gene RIFs: 124   (req: <= 3)
Antibodies: 518   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 709.06   (req: >= 5)
Gene RIFs: 124   (req: > 3)
Antibodies: 518   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
superoxide dismutase 3
VGNC:8178
461143
Macaque
superoxide dismutase 3
715931
Mouse
MGI:103181
20657
Rat
RGD:3733
25352
Dog
superoxide dismutase 3
VGNC:46654
488855
Species
Name
OMA
EggNOG
Inparanoid
Chimp
superoxide dismutase 3
Macaque
superoxide dismutase 3
Mouse
Rat
Dog
superoxide dismutase 3
Protein Structure (1 Structure, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P08294-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (25)
Cellular responses to external stimuli (R-HSA-8953897)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cellular responses to external stimuli
Reactome
Cellular responses to stress
Reactome
Detoxification of Reactive Oxygen Species
Name
Explore in Pharos
Explore in Source
Cellular responses to external stimuli
Cellular responses to stress
Detoxification of Reactive Oxygen Species
Gene Ontology Terms (16)
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (120)
1 – 10 of 120
SOD2
Tbio
Family: Enzyme
Novelty: 0.00084288
Score: 0.995
Data Source: STRINGDB
CAT
Tbio
Family: Enzyme
Novelty: 0.00181888
Score: 0.989
Data Source: STRINGDB
ATOX1
Tbio
Novelty: 0.00509938
Score: 0.986
Data Source: STRINGDB
ATP7A
Tbio
Family: Enzyme
Novelty: 0.00064155
Score: 0.98
Data Source: STRINGDB
GPX1
Tbio
Family: Enzyme
Novelty: 0.000826
Score: 0.973
Data Source: STRINGDB
GPX3
Tbio
Family: Enzyme
Novelty: 0.0015734
Score: 0.969
Data Source: STRINGDB
GPX2
Tbio
Family: Enzyme
Novelty: 0.00479104
Score: 0.963
Data Source: STRINGDB
GPX7
Tbio
Family: Enzyme
Novelty: 0.01342855
Score: 0.962
Data Source: STRINGDB
GPX5
Tbio
Family: Enzyme
Novelty: 0.01204448
Score: 0.96
Data Source: STRINGDB
GPX8
Tbio
Family: Enzyme
Novelty: 0.02304355
Score: 0.957
Data Source: STRINGDB
Publication Statistics
PubMed Score  709.06

PubMed score by year
PubTator Score  323.56

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer