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Tchem
MMP2
72 kDa type IV collagenase

Protein Summary
Description
Ubiquitinous metalloproteinase that is involved in diverse functions such as remodeling of the vasculature, angiogenesis, tissue repair, tumor invasion, inflammation, and atherosclerotic plaque rupture. As well as degrading extracellular matrix proteins, can also act on several nonmatrix proteins such as big endothelial 1 and beta-type CGRP promoting vasoconstriction. Also cleaves KISS at a Gly-|-Leu bond. Appears to have a role in myocardial cell death pathways. Contributes to myocardial oxidative stress by regulating the activity of GSK3beta. Cleaves GSK3beta in vitro. Involved in the formation of the fibrovascular tissues in association with MMP14. PEX, the C-terminal non-catalytic fragment of MMP2, posseses anti-angiogenic and anti-tumor properties and inhibits cell migration and cell adhesion to FGF2 and vitronectin. Ligand for integrinv/beta3 on the surface of blood vessels. Isoform 2: Mediates the proteolysis of CHUK/IKKA and initiates a primary innate immune response by inducin ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000219070
  • ENSP00000219070
  • ENSG00000087245
  • ENST00000437642
  • ENSP00000394237
  • ENST00000543485
  • ENSP00000444143
  • ENST00000570308
  • ENSP00000461421

Symbol
  • CLG4A
  • CLG4
  • MONA
  • CLG4A
  • MMP-2
  • TBE-1
  • MMP-II
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
chemical
1
protein domain
1
kinase perturbation
0.91
PubMedID
0.81
disease
0.74


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 7640.54   (req: < 5)
Gene RIFs: 1527   (req: <= 3)
Antibodies: 1510   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 7640.54   (req: >= 5)
Gene RIFs: 1527   (req: > 3)
Antibodies: 1510   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 20
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 2252
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
heel bone mineral density
2
2
2
93.8
age-related hearing impairment
1
1
0
5.7
60.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
heel bone mineral density
2
93.8
age-related hearing impairment
0
5.7
60.7
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
matrix metallopeptidase 2
VGNC:5839
454094
Macaque
matrix metallopeptidase 2
698478
Mouse
MGI:97009
17390
Rat
RGD:621316
81686
Dog
matrix metallopeptidase 2
VGNC:43280
403733
Species
Name
OMA
EggNOG
Inparanoid
Chimp
matrix metallopeptidase 2
Macaque
matrix metallopeptidase 2
Mouse
Rat
Dog
matrix metallopeptidase 2
Protein Data Bank (11)
1 – 5 of 11
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (209)
Activation of Matrix Metalloproteinases (R-HSA-1592389)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 20
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Activation of Matrix Metalloproteinases
Reactome
Axon guidance
Reactome
Collagen degradation
Reactome
Cytokine Signaling in Immune system
Reactome
Degradation of the extracellular matrix
Name
Explore in Pharos
Explore in Source
Activation of Matrix Metalloproteinases
Axon guidance
Collagen degradation
Cytokine Signaling in Immune system
Degradation of the extracellular matrix
Protein-Protein Interactions (433)
1 – 10 of 433
COL14A1
Tbio
Novelty: 0.01760399
p_int: 0.999990076
p_ni: 0.000009924
Score: 0.444
Data Source: BioPlex,STRINGDB
COL12A1
Tbio
Novelty: 0.0239421
p_int: 0.999976774
p_ni: 4.9e-7
p_wrong: 0.000022737
Score: 0.55
Data Source: BioPlex,STRINGDB
COL2A1
Tbio
Novelty: 0.0011102
p_int: 0.999937648
p_ni: 0.000062306
p_wrong: 4.6e-8
Score: 0.497
Data Source: BioPlex,STRINGDB
FN1
Tchem
Novelty: 0.00003647
p_int: 0.999921617
p_ni: 0.000078383
Score: 0.605
Data Source: BioPlex,STRINGDB
COL18A1
Tbio
Novelty: 0.00074602
p_int: 0.999641796
p_ni: 0.000358203
Score: 0.985
Data Source: BioPlex,STRINGDB
HIST2H2AC
Tbio
Novelty: 0.00065524
p_int: 0.999562465
p_ni: 0.000437535
Score: 0.304
Data Source: BioPlex,STRINGDB
COL4A2
Tbio
Novelty: 0.00782053
p_int: 0.998648391
p_ni: 0.001351609
Score: 0.613
Data Source: BioPlex,STRINGDB
EDA
Tbio
Novelty: 0.00352464
p_int: 0.995426074
p_ni: 0.001398653
p_wrong: 0.003175272
Score: 0.314
Data Source: BioPlex,STRINGDB
COL5A1
Tbio
Novelty: 0.00506815
p_int: 0.993727212
p_ni: 0.000010308
p_wrong: 0.006262479
Score: 0.804
Data Source: BioPlex,STRINGDB
COL6A1
Tbio
Novelty: 0.00644855
p_int: 0.987655458
p_ni: 0.012344542
Score: 0.864
Data Source: BioPlex,STRINGDB
Publication Statistics
PubMed Score  7640.54

PubMed score by year
PubTator Score  7094.28

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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