Tclin ELANE Neutrophil elastase

Protein Summary

Description

Modifies the functions of natural killer cells, monocytes and granulocytes. Inhibits C5a-dependent neutrophil enzyme release and chemotaxis. Elastases form a subfamily of serine proteases that hydrolyze many proteins in addition to elastin. Humans have six elastase genes which encode structurally similar proteins. The encoded preproprotein is proteolytically processed to generate the active protease. Following activation, this protease hydrolyzes proteins within specialized neutrophil lysosomes, called azurophil granules, as well as proteins of the extracellular matrix. The enzyme may play a role in degenerative and inflammatory diseases through proteolysis of collagen-IV and elastin. This protein also degrades the outer membrane protein A (OmpA) of E. coli as well as the virulence factors of such bacteria as Shigella, Salmonella and Yersinia. Mutations in this gene are associated with cyclic neutropenia and severe congenital neutropenia (SCN). This gene is present in a gene cluster on chromosome 19. [provided by RefSeq, Jan 2016]

Uniprot Accession IDs

• P08246
• P09649
• Q6B0D9
• Q6LDP5

Gene Name

• ELANE

Ensembl ID

• ENST00000263621
• ENSP00000263621
• ENSG00000197561
• ENST00000590230
• ENSP00000466090
• ENST00000615489
• ENSP00000480128
• ENSG00000277571
• ENST00000632488
• ENSP00000488075

Symbol

• ELA2
• GE
• NE
• HLE
• HNE
• ELA2
• SCN1
• PMN-E

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
biological process	1
biological term	0.98
molecular function	0.9
cellular component	0.75
gene perturbation	0.72

Protein Classes

PANTHER Classes

Protein / Hydrolase / Protease / Serine Protease / Neutrophil Elastase

DTO Classes

Protein / Enzyme / Protease / Serine Protease / Neutrophil Elastase

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3818.92   (req: < 5)

Gene RIFs: 246   (req: <= 3)

Antibodies: 600   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3818.92   (req: >= 5)

Gene RIFs: 246   (req: > 3)

Antibodies: 600   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 34

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 1770

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 2