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Tchem
ASNS
Asparagine synthetase [glutamine-hydrolyzing]

Protein Classes
Protein Summary
Description
The protein encoded by this gene is involved in the synthesis of asparagine. This gene complements a mutation in the temperature-sensitive hamster mutant ts11, which blocks progression through the G1 phase of the cell cycle at nonpermissive temperature. Alternatively spliced transcript variants have been described for this gene. [provided by RefSeq, May 2010]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000175506
  • ENSP00000175506
  • ENSG00000070669
  • ENST00000394308
  • ENSP00000377845
  • ENST00000394309
  • ENSP00000377846
  • ENST00000422745
  • ENSP00000414901
  • ENST00000437628
  • ENSP00000414379
  • ENST00000444334
  • ENSP00000406994
  • ENST00000455086
  • ENSP00000408472

Symbol
  • TS11
  • TS11
  • ASNSD
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
1
kinase perturbation
0.99
PubMedID
0.99
gene perturbation
0.98
transcription factor perturbation
0.97


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 263.85   (req: < 5)
Gene RIFs: 36   (req: <= 3)
Antibodies: 328   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 263.85   (req: >= 5)
Gene RIFs: 36   (req: > 3)
Antibodies: 328   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 20
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 3
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Pathways (20)
ATF4 activates genes in response to endoplasmic reticulum stress (R-HSA-380994)

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Items per page:
1 – 5 of 7
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
ATF4 activates genes in response to endoplasmic reticulum stress
Reactome
Aspartate and asparagine metabolism
Reactome
Metabolism
Reactome
Metabolism of amino acids and derivatives
Reactome
Metabolism of proteins
Name
Explore in Pharos
Explore in Source
ATF4 activates genes in response to endoplasmic reticulum stress
Aspartate and asparagine metabolism
Metabolism
Metabolism of amino acids and derivatives
Metabolism of proteins
Protein-Protein Interactions (145)
1 – 10 of 145
ASS1
Tbio
Family: Enzyme
Novelty: 0.00451148
Score: 0.993
Data Source: STRINGDB
ATF4
Tbio
Family: TF
Novelty: 0.00139602
Score: 0.986
Data Source: STRINGDB
GARS
Tbio
Family: Enzyme
Novelty: 0.00380565
Score: 0.964
Data Source: STRINGDB
GOT2
Tbio
Family: Enzyme
Novelty: 0.00062666
Score: 0.963
Data Source: STRINGDB
CAD
Tchem
Novelty: 0.00769545
Score: 0.95
Data Source: STRINGDB
GOT1
Tbio
Family: Enzyme
Novelty: 0.00607491
Score: 0.944
Data Source: STRINGDB
ADSS
Tchem
Family: Enzyme
Novelty: 0.0101455
Score: 0.921
Data Source: STRINGDB
ADSSL1
Tbio
Family: Enzyme
Novelty: 0.06341789
Score: 0.916
Data Source: STRINGDB
ASPA
Tbio
Family: Enzyme
Novelty: 0.00421309
Score: 0.91
Data Source: STRINGDB
EPRS
Tchem
Family: Enzyme
Novelty: 0.00072148
Score: 0.909
Data Source: STRINGDB
Publication Statistics
PubMed Score  263.85

PubMed score by year
PubTator Score  85.28

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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