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Tchem
ASNS
Asparagine synthetase [glutamine-hydrolyzing]

Protein Summary
Description
The protein encoded by this gene is involved in the synthesis of asparagine. This gene complements a mutation in the temperature-sensitive hamster mutant ts11, which blocks progression through the G1 phase of the cell cycle at nonpermissive temperature. Alternatively spliced transcript variants have been described for this gene. [provided by RefSeq, May 2010]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000175506
  • ENSP00000175506
  • ENSG00000070669
  • ENST00000394308
  • ENSP00000377845
  • ENST00000394309
  • ENSP00000377846
  • ENST00000422745
  • ENSP00000414901
  • ENST00000437628
  • ENSP00000414379
  • ENST00000444334
  • ENSP00000406994
  • ENST00000455086
  • ENSP00000408472

Symbol
  • TS11
  • TS11
  • ASNSD
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
1
kinase perturbation
0.99
PubMedID
0.99
gene perturbation
0.98
transcription factor perturbation
0.97


Protein Classes
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 411.17   (req: < 5)
Gene RIFs: 36   (req: <= 3)
Antibodies: 328   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 411.17   (req: >= 5)
Gene RIFs: 36   (req: > 3)
Antibodies: 328   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 20
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 3
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Protein-Protein Interactions (145)
ASS1
Tbio
Family:  Enzyme
Novelty:  0.00358761
Score:  0.993
Data Source:  STRINGDB
ATF4
Tbio
Family:  TF
Novelty:  0.00253408
Score:  0.986
Data Source:  STRINGDB
GARS
Tchem
Family:  Enzyme
Novelty:  0.00190498
Score:  0.964
Data Source:  STRINGDB
GOT2
Tbio
Family:  Enzyme
Novelty:  0.00054023
Score:  0.963
Data Source:  STRINGDB
CAD
Tchem
Novelty:  0.00651422
Score:  0.95
Data Source:  STRINGDB
GOT1
Tbio
Family:  Enzyme
Novelty:  0.00448817
Score:  0.944
Data Source:  STRINGDB
ADSS
Tchem
Family:  Enzyme
Novelty:  0.0126472
Score:  0.921
Data Source:  STRINGDB
ADSSL1
Tbio
Family:  Enzyme
Novelty:  0.0511949
Score:  0.916
Data Source:  STRINGDB
ASPA
Tbio
Family:  Enzyme
Novelty:  0.02701619
Score:  0.91
Data Source:  STRINGDB
EPRS
Tchem
Family:  Enzyme
Novelty:  0.00084896
Score:  0.909
Data Source:  STRINGDB
Pathways (20)
ATF4 activates genes in response to endoplasmic reticulum stress (R-HSA-380994)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 7
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
ATF4 activates genes in response to endoplasmic reticulum stress
Reactome
Aspartate and asparagine metabolism
Reactome
Metabolism
Reactome
Metabolism of amino acids and derivatives
Reactome
Metabolism of proteins
Name
Explore in Pharos
Explore in Source
ATF4 activates genes in response to endoplasmic reticulum stress
Aspartate and asparagine metabolism
Metabolism
Metabolism of amino acids and derivatives
Metabolism of proteins
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (6)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
asparagine measurement
1
1
0
9.2
75.6
antisocial behaviour measurement
1
1
1
10.4
1
1
1
10.4
substance abuse
1
1
1
10.4
social interaction measurement
1
1
1
6.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
asparagine measurement
0
9.2
75.6
antisocial behaviour measurement
1
10.4
1
10.4
substance abuse
1
10.4
social interaction measurement
1
6.6
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (15)
1 – 5 of 15
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
asparagine synthetase (glutamine-hydrolyzing)
VGNC:7214
463556
Macaque
asparagine synthetase (glutamine-hydrolyzing)
697232
Mouse
MGI:1350929
27053
Rat
RGD:2162
25612
Dog
asparagine synthetase (glutamine-hydrolyzing)
VGNC:53542
475240
Species
Name
OMA
EggNOG
Inparanoid
Chimp
asparagine synthetase (glutamine-hydrolyzing)
Macaque
asparagine synthetase (glutamine-hydrolyzing)
Mouse
Rat
Dog
asparagine synthetase (glutamine-hydrolyzing)
Publication Statistics
PubMed Score 411.17
PubMed score by year
PubTator Score 85.28
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title