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Tchem
SRPRA
Signal recognition particle receptor subunit alpha

Protein Summary
Description
Component of the SRP (signal recognition particle) receptor. Ensures, in conjunction with the signal recognition particle, the correct targeting of the nascent secretory proteins to the endoplasmic reticulum membrane system. The gene encodes a subunit of the endoplasmic reticulum signal recognition particle receptor that, in conjunction with the signal recognition particle, is involved in the targeting and translocation of signal sequence tagged secretory and membrane proteins across the endoplasmic reticulum. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2010]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000332118
  • ENSP00000328023
  • ENSG00000182934
  • ENST00000532259
  • ENSP00000435508

Symbol
  • SRPR
  • DP
  • SRPR
  • Sralpha
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0
biological term
0
cell line
0
cell type or tissue
0
cellular component
0


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 66.69   (req: < 5)
Gene RIFs: 0   (req: <= 3)
Antibodies: 142   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 66.69   (req: >= 5)
Gene RIFs: 0   (req: > 3)
Antibodies: 142   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 1
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Active Ligands (1)
1 – 1 of 1
ENMD-2076
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Protein-Protein Interactions (209)
1 – 10 of 209
SRPRB
Tbio
Novelty:  0.04735362
p_int:  0.999998295
p_ni:  0.000001705
Score:  0.999
Data Source:  BioPlex,Reactome,STRINGDB
DDRGK1
Tbio
Novelty:  0.10774064
p_int:  0.977113863
p_ni:  0.022886137
Score:  0.799
Data Source:  BioPlex,STRINGDB
SLC39A9
Tbio
Family:  Transporter
Novelty:  0.06143625
p_int:  0.969752024
p_ni:  0.030247976
Data Source:  BioPlex
ANXA13
Tbio
Novelty:  0.01534307
p_int:  0.965466116
p_ni:  0.002185688
p_wrong:  0.032348196
Score:  0.215
Data Source:  BioPlex,STRINGDB
IL27RA
Tbio
Novelty:  0.01348051
p_int:  0.941869685
p_ni:  0.052732484
p_wrong:  0.00539783
Score:  0.183
Data Source:  BioPlex,STRINGDB
ZDHHC17
Tbio
Family:  Enzyme
Novelty:  0.03288707
p_int:  0.906228253
p_ni:  0.093771708
p_wrong:  3.8e-8
Score:  0.181
Data Source:  BioPlex,STRINGDB
EVA1B
Tdark
Novelty:  2.1380272
p_int:  0.857985768
p_ni:  0.142014232
Data Source:  BioPlex
PLAC9
Tdark
Novelty:  0.23764669
p_int:  0.842347112
p_ni:  0.157652888
Data Source:  BioPlex
SLC39A12
Tbio
Family:  Transporter
Novelty:  0.09127395
p_int:  0.790587473
p_ni:  0.209412527
Data Source:  BioPlex
PIK3IP1
Tbio
Family:  Enzyme
Novelty:  0.07364653
p_int:  0.750926451
p_ni:  0.249073548
Data Source:  BioPlex
Pathways (7)
IRE1alpha activates chaperones (R-HSA-381070)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 6
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
IRE1alpha activates chaperones
Reactome
Metabolism of proteins
Reactome
SRP-dependent cotranslational protein targeting to membrane
Reactome
Translation
Reactome
Unfolded Protein Response (UPR)
Name
Explore in Pharos
Explore in Source
IRE1alpha activates chaperones
Metabolism of proteins
SRP-dependent cotranslational protein targeting to membrane
Translation
Unfolded Protein Response (UPR)
Gene Ontology Terms (12)
Items per page:
10
1 – 4 of 4
GO Term
Evidence
Assigned by
Inferred from High Throughput Direct Assay (HDA)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
GWAS Traits (20)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
low density lipoprotein cholesterol measurement
7
8
10
98.3
apolipoprotein B measurement
2
6
6
98
total cholesterol measurement
2
4
5
94.2
calcium measurement
1
2
2
91.9
ST2 protein measurement
1
1
1
81.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
low density lipoprotein cholesterol measurement
10
98.3
apolipoprotein B measurement
6
98
total cholesterol measurement
5
94.2
calcium measurement
2
91.9
ST2 protein measurement
1
81.2
Find similar targets by:
Orthologs (15)
1 – 5 of 15
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
SRP receptor subunit alpha
VGNC:3058
466844
Macaque
SRP receptor alpha subunit
714215
Mouse
MGI:1914648
67398
Rat
RGD:1311504
315548
Dog
SRP receptor subunit alpha
VGNC:53450
489293
Species
Name
OMA
EggNOG
Inparanoid
Chimp
SRP receptor subunit alpha
Macaque
SRP receptor alpha subunit
Mouse
Rat
Dog
SRP receptor subunit alpha
Publication Statistics
PubMed Score 66.69
PubMed score by year
PubTator Score 22.14
PubTator score by year