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Tchem
HSP90AB1
Heat shock protein HSP 90-beta

Protein Summary
Description
Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function (PubMed:16478993, PubMed:19696785). Engages with a range of client protein classes via its interaction with various co-chaperone proteins or complexes, that act as adapters, simultaneously able to interact with the specific client and the central chaperone itself. Recruitment of ATP and co-chaperone followed by client protein forms a functional chaperone. After the completion of the chaperoning process, properly folded client protein and co-chaperone leave HSP90 in an ADP-bound partially open conform ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000353801
  • ENSP00000325875
  • ENSG00000096384
  • ENST00000371554
  • ENSP00000360609
  • ENST00000371646
  • ENSP00000360709
  • ENST00000620073
  • ENSP00000481908

Symbol
  • HSP90B
  • HSPC2
  • HSPCB
  • HSP84
  • HSPC2
  • HSPCB
  • D6S182
  • HSP90B
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
hub protein
1
interacting protein
1
molecular function
1
protein complex
1
biological process
0.99


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 87.83   (req: < 5)
Gene RIFs: 64   (req: <= 3)
Antibodies: 1559   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 87.83   (req: >= 5)
Gene RIFs: 64   (req: > 3)
Antibodies: 1559   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 76
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 333
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean reticulocyte volume
1
1
1
50.9
reticulocyte count
1
1
1
17.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean reticulocyte volume
1
50.9
reticulocyte count
1
17.5
Protein Data Bank (15)
1 – 5 of 15
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (92)
Aryl hydrocarbon receptor signalling (R-HSA-8937144)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 38
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Aryl hydrocarbon receptor signalling
Reactome
Attenuation phase
Reactome
Autophagy
Reactome
Axon guidance
Reactome
Biological oxidations
Name
Explore in Pharos
Explore in Source
Aryl hydrocarbon receptor signalling
Attenuation phase
Autophagy
Axon guidance
Biological oxidations
Gene Ontology Terms (102)
Items per page:
10
1 – 10 of 30
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
CAFA
Inferred from Direct Assay (IDA)
MGI
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
CAFA
Inferred from Physical Interaction (IPI)
CAFA
Inferred from Physical Interaction (IPI)
CAFA
Inferred from Physical Interaction (IPI)
BHF-UCL
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Physical Interaction (IPI)
BHF-UCL
Inferred from Physical Interaction (IPI)
UniProtKB
Protein-Protein Interactions (526)
1 – 10 of 526
HSP90AB4P
Tdark
p_int: 0.999999926
p_ni: 7.4e-8
Data Source: BioPlex
HSP90AB3P
Tdark
p_int: 0.999999919
p_ni: 8.1e-8
Data Source: BioPlex
HSP90AA4P
Tdark
p_int: 0.999999889
p_ni: 1.11e-7
Data Source: BioPlex
HSP90AA5P
Tdark
p_int: 0.999999602
p_ni: 3.98e-7
Data Source: BioPlex
EDRF1
Tbio
Novelty: 0.24333657
p_int: 0.999999215
p_ni: 7.85e-7
Data Source: BioPlex
CDC37L1
Tbio
Novelty: 0.11043692
p_int: 0.999857102
p_ni: 3.05e-7
p_wrong: 0.000142592
Score: 0.852
Data Source: BioPlex,STRINGDB
HSP90AA1
Tchem
Novelty: 0.00016774
p_int: 0.999660179
p_ni: 0.000339821
Score: 0.997
Data Source: BioPlex,Reactome,STRINGDB
RPS6KA4
Tchem
Family: Kinase
Novelty: 0.05213255
p_int: 0.999577733
p_ni: 0.000422268
Data Source: BioPlex
PINK1
Tbio
Family: Kinase
Novelty: 0.00100973
p_int: 0.999260833
p_ni: 0.000739167
Score: 0.635
Data Source: BioPlex,STRINGDB
CDK9
Tchem
Family: Kinase
Novelty: 0.00210218
p_int: 0.997757493
p_ni: 0.002242507
Score: 0.276
Data Source: BioPlex,STRINGDB
Publication Statistics
PubMed Score  87.83

PubMed score by year
PubTator Score  152.17

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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