Tbio PFKM ATP-dependent 6-phosphofructokinase, muscle type

Protein Summary

Description

Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis. Three phosphofructokinase isozymes exist in humans: muscle, liver and platelet. These isozymes function as subunits of the mammalian tetramer phosphofructokinase, which catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-bisphosphate. Tetramer composition varies depending on tissue type. This gene encodes the muscle-type isozyme. Mutations in this gene have been associated with glycogen storage disease type VII, also known as Tarui disease. Alternatively spliced transcript variants have been described.[provided by RefSeq, Nov 2009]

Uniprot Accession IDs

• P08237
• J3KNX3
• Q16814
• Q16815
• Q6ZTT1
• ATP-PFK

Gene Name

• PFKM

Ensembl ID

• ENST00000312352
• ENSP00000309438
• ENSG00000152556
• ENST00000340802
• ENSP00000345771
• ENST00000359794
• ENSP00000352842
• ENST00000547587
• ENSP00000449426
• ENST00000550345
• ENSP00000450369
• ENST00000550924
• ENSP00000446945
• ENST00000551339
• ENSP00000448253
• ENST00000551804
• ENSP00000448177

Symbol

• PFKX
• GSD7
• PFK1
• PFKA
• PFKX
• PFK-1
• PFK-A
• ATP-PFK
• PPP1R122

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
molecular function	0.99
virus perturbation	0.99
disease perturbation	0.98
hub protein	0.98
histone modification site profile	0.9

Protein Classes

PANTHER Classes

Protein / Transferase / Kinase / Carbohydrate Kinase / Atp-dependent 6-phosphofructokinase, Muscle Type

DTO Classes

Protein / Kinase / Unclassified Protein / Atp-dependent 6-phosphofructokinase, Muscle Type

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 561.39   (req: < 5)

Gene RIFs: 31   (req: <= 3)

Antibodies: 430   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 561.39   (req: >= 5)

Gene RIFs: 31   (req: > 3)

Antibodies: 430   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 24

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0