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Tbio
PFKM
ATP-dependent 6-phosphofructokinase, muscle type

Protein Summary
Description
Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis. Three phosphofructokinase isozymes exist in humans: muscle, liver and platelet. These isozymes function as subunits of the mammalian tetramer phosphofructokinase, which catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-bisphosphate. Tetramer composition varies depending on tissue type. This gene encodes the muscle-type isozyme. Mutations in this gene have been associated with glycogen storage disease type VII, also known as Tarui disease. Alternatively spliced transcript variants have been described.[provided by RefSeq, Nov 2009]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000312352
  • ENSP00000309438
  • ENSG00000152556
  • ENST00000340802
  • ENSP00000345771
  • ENST00000359794
  • ENSP00000352842
  • ENST00000547587
  • ENSP00000449426
  • ENST00000550345
  • ENSP00000450369
  • ENST00000550924
  • ENSP00000446945
  • ENST00000551339
  • ENSP00000448253
  • ENST00000551804
  • ENSP00000448177

Symbol
  • PFKX
  • GSD7
  • PFK1
  • PFKA
  • PFKX
  • PFK-1
  • PFK-A
  • ATP-PFK
  • PPP1R122
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.99
virus perturbation
0.99
disease perturbation
0.98
hub protein
0.98
histone modification site profile
0.9


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 561.39   (req: < 5)
Gene RIFs: 18   (req: <= 3)
Antibodies: 430   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 561.39   (req: >= 5)
Gene RIFs: 18   (req: > 3)
Antibodies: 430   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 24
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0