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Tchem
GUSB
Beta-glucuronidase

Protein Summary
Description
Plays an important role in the degradation of dermatan and keratan sulfates. This gene encodes a hydrolase that degrades glycosaminoglycans, including heparan sulfate, dermatan sulfate, and chondroitin-4,6-sulfate. The enzyme forms a homotetramer that is localized to the lysosome. Mutations in this gene result in mucopolysaccharidosis type VII. Alternative splicing results in multiple transcript variants. There are many pseudogenes of this locus in the human genome.[provided by RefSeq, May 2014]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000304895
  • ENSP00000302728
  • ENSG00000169919
  • ENST00000421103
  • ENSP00000391390

Symbol
  • BG
  • MPS7
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
1
protein domain
1
virus perturbation
1
transcription factor perturbation
0.94
pathway
0.88


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1430.96   (req: < 5)
Gene RIFs: 18   (req: <= 3)
Antibodies: 354   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1430.96   (req: >= 5)
Gene RIFs: 18   (req: > 3)
Antibodies: 354   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 41
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Active Ligands (41)
1 – 10 of 41
US9334288, 9
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CHEMBL3903683
Rendered image for CHEMBL3903683
CHEMBL4635113
Rendered image for CHEMBL4635113
CHEMBL1236932
Rendered image for CHEMBL1236932
CHEMBL2335167
Rendered image for CHEMBL2335167
CHEMBL4165927
Rendered image for CHEMBL4165927
CHEMBL4168635
Rendered image for CHEMBL4168635
CHEMBL4642327
Rendered image for CHEMBL4642327
CHEMBL4642420
Rendered image for CHEMBL4642420
Protein-Protein Interactions (233)
1 – 10 of 233
HOXA3
Tbio
Family:  TF
Novelty:  0.01407069
p_int:  0.999930799
p_wrong:  0.000069201
Score:  0.688
Data Source:  BioPlex,STRINGDB
PMEL
Tbio
Novelty:  0.00116525
p_int:  0.999457311
p_ni:  0.000542688
Score:  0.208
Data Source:  BioPlex,STRINGDB
CDK4
Tclin
Family:  Kinase
Novelty:  0.00036742
p_int:  0.989904983
p_ni:  0.010095017
Score:  0.241
Data Source:  BioPlex,STRINGDB
IDS
Tbio
Family:  Enzyme
Novelty:  0.00733996
p_int:  0.847783834
p_ni:  0.152216166
Score:  0.722
Data Source:  BioPlex,STRINGDB
CES1
Tchem
Family:  Enzyme
Novelty:  0.00092608
Score:  0.979
Data Source:  STRINGDB
MAN2B1
Tchem
Family:  Enzyme
Novelty:  0.0051017
Score:  0.967
Data Source:  STRINGDB
GLA
Tclin
Family:  Enzyme
Novelty:  0.00075604
Score:  0.967
Data Source:  STRINGDB
GLB1
Tchem
Family:  Enzyme
Novelty:  0.00241713
Score:  0.964
Data Source:  STRINGDB
ARSB
Tbio
Family:  Enzyme
Novelty:  0.01044355
Score:  0.962
Data Source:  STRINGDB
ARSA
Tbio
Family:  Enzyme
Novelty:  0.00469851
Score:  0.954
Data Source:  STRINGDB
Pathways (21)
Disease (R-HSA-1643685)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 15
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Disease
Reactome
Diseases of carbohydrate metabolism
Reactome
Diseases of metabolism
Reactome
Glycosaminoglycan metabolism
Reactome
HS-GAG degradation
Name
Explore in Pharos
Explore in Source
Disease
Diseases of carbohydrate metabolism
Diseases of metabolism
Glycosaminoglycan metabolism
HS-GAG degradation
GWAS Traits (4)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
neutrophil count
1
1
1
60.2
alkaline phosphatase measurement
1
1
1
13.3
glomerular filtration rate
1
1
1
12.7
corneal topography
1
1
1
6.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
neutrophil count
1
60.2
alkaline phosphatase measurement
1
13.3
glomerular filtration rate
1
12.7
corneal topography
1
6.1
Find similar targets by:
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
glucuronidase beta
VGNC:8690
463443
Mouse
MGI:95872
110006
Rat
RGD:2772
24434
Dog
glucuronidase beta
VGNC:54034
403831
Horse
glucuronidase beta
VGNC:51148
100037416
Species
Name
OMA
EggNOG
Inparanoid
Chimp
glucuronidase beta
Mouse
Rat
Dog
glucuronidase beta
Horse
glucuronidase beta
Publication Statistics
PubMed Score 1430.96
PubMed score by year
PubTator Score 2154.95
PubTator score by year