You are using an outdated browser. Please upgrade your browser to improve your experience.

Tchem
GUSB
Beta-glucuronidase

Protein Summary
Description
Plays an important role in the degradation of dermatan and keratan sulfates. This gene encodes a hydrolase that degrades glycosaminoglycans, including heparan sulfate, dermatan sulfate, and chondroitin-4,6-sulfate. The enzyme forms a homotetramer that is localized to the lysosome. Mutations in this gene result in mucopolysaccharidosis type VII. Alternative splicing results in multiple transcript variants. There are many pseudogenes of this locus in the human genome.[provided by RefSeq, May 2014]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000304895
  • ENSP00000302728
  • ENSG00000169919
  • ENST00000421103
  • ENSP00000391390

Symbol
  • BG
  • MPS7
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
1
protein domain
1
virus perturbation
1
transcription factor perturbation
0.94
pathway
0.88


Related Tools
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1423.49   (req: < 5)
Gene RIFs: 18   (req: <= 3)
Antibodies: 354   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1423.49   (req: >= 5)
Gene RIFs: 18   (req: > 3)
Antibodies: 354   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 9
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
glucuronidase beta
VGNC:8690
463443
Mouse
MGI:95872
110006
Rat
RGD:2772
24434
Dog
glucuronidase beta
VGNC:54034
403831
Horse
glucuronidase beta
VGNC:51148
100037416
Species
Name
OMA
EggNOG
Inparanoid
Chimp
glucuronidase beta
Mouse
Rat
Dog
glucuronidase beta
Horse
glucuronidase beta
Protein Structure (2 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P08236-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 2 of 2
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (21)
Disease (R-HSA-1643685)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 15
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Disease
Reactome
Diseases of carbohydrate metabolism
Reactome
Diseases of metabolism
Reactome
Glycosaminoglycan metabolism
Reactome
HS-GAG degradation
Name
Explore in Pharos
Explore in Source
Disease
Diseases of carbohydrate metabolism
Diseases of metabolism
Glycosaminoglycan metabolism
HS-GAG degradation
Protein-Protein Interactions (233)
1 – 10 of 233
HOXA3
Tbio
Family: TF
Novelty: 0.01407069
p_int: 0.999930799
p_wrong: 0.000069201
Score: 0.688
Data Source: BioPlex,STRINGDB
PMEL
Tbio
Novelty: 0.00116525
p_int: 0.999457311
p_ni: 0.000542688
Score: 0.208
Data Source: BioPlex,STRINGDB
CDK4
Tclin
Family: Kinase
Novelty: 0.00036742
p_int: 0.989904983
p_ni: 0.010095017
Score: 0.241
Data Source: BioPlex,STRINGDB
IDS
Tbio
Family: Enzyme
Novelty: 0.00733996
p_int: 0.847783834
p_ni: 0.152216166
Score: 0.722
Data Source: BioPlex,STRINGDB
CES1
Tchem
Family: Enzyme
Novelty: 0.00092608
Score: 0.979
Data Source: STRINGDB
MAN2B1
Tchem
Family: Enzyme
Novelty: 0.0051017
Score: 0.967
Data Source: STRINGDB
GLA
Tclin
Family: Enzyme
Novelty: 0.00075604
Score: 0.967
Data Source: STRINGDB
GLB1
Tchem
Family: Enzyme
Novelty: 0.00241713
Score: 0.964
Data Source: STRINGDB
ARSB
Tbio
Family: Enzyme
Novelty: 0.01044355
Score: 0.962
Data Source: STRINGDB
ARSA
Tbio
Family: Enzyme
Novelty: 0.00469851
Score: 0.954
Data Source: STRINGDB
Publication Statistics
PubMed Score  1423.49

PubMed score by year
PubTator Score  2154.95

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
Find similar targets by: