NR3C2
Mineralocorticoid receptor
Protein Summary
Receptor for both mineralocorticoids (MC) such as aldosterone and glucocorticoids (GC) such as corticosterone or cortisol. Binds to mineralocorticoid response elements (MRE) and transactivates target genes. The effect of MC is to increase ion and water transport and thus raise extracellular fluid volume and blood pressure and lower potassium levels. This gene encodes the mineralocorticoid receptor, which mediates aldosterone actions on salt and water balance within restricted target cells. The protein functions as a ligand-dependent transcription factor that binds to mineralocorticoid response elements in order to transactivate target genes. Mutations in this gene cause autosomal dominant pseudohypoaldosteronism type I, a disorder characterized by urinary salt wasting. Defects in this gene are also associated with early onset hypertension with severe exacerbation in pregnancy. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2009]
- ENST00000342437
- ENSP00000343907
- ENSG00000151623
- ENST00000344721
- ENSP00000341390
- ENST00000358102
- ENSP00000350815
- ENST00000511528
- ENSP00000421481
- ENST00000512865
- ENSP00000423510
- ENST00000625323
- ENSP00000486719
- MCR
- MLR
- MR
- MCR
- MLR
- NR3C2VIT
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
co-expressed gene | 1 | ||
virus perturbation | 0.9 | ||
microRNA | 0.83 | ||
disease | 0.82 | ||
molecular function | 0.76 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 5678.7 (req: < 5)
Gene RIFs: 225 (req: <= 3)
Antibodies: 267 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 5678.7 (req: >= 5)
Gene RIFs: 225 (req: > 3)
Antibodies: 267 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 8
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligands: 286
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drugs: 18