CELA2A
Chymotrypsin-like elastase family member 2A
Protein Summary
Acts upon elastin. Elastases form a subfamily of serine proteases that hydrolyze many proteins in addition to elastin. Humans have six elastase genes which encode the structurally similar proteins elastase 1, 2, 2A, 2B, 3A, and 3B. Like most of the human elastases, elastase 2A is secreted from the pancreas as a zymogen. In other species, elastase 2A has been shown to preferentially cleave proteins after leucine, methionine, and phenylalanine residues. [provided by RefSeq, May 2009]
- ENST00000359621
- ENSP00000352639
- ENSG00000142615
- ELA2A
- PE-1
- ELA2A
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
cell type or tissue | 0.61 | ||
gene perturbation | 0.6 | ||
tissue sample | 0.6 | ||
protein domain | 0.58 | ||
cell line | 0.49 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 7.2 (req: < 5)
Gene RIFs: 4 (req: <= 3)
Antibodies: 100 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 7.2 (req: >= 5)
Gene RIFs: 4 (req: > 3)
Antibodies: 100 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 5
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0