CELA2A
Chymotrypsin-like elastase family member 2A
Protein Summary
Acts upon elastin. Elastases form a subfamily of serine proteases that hydrolyze many proteins in addition to elastin. Humans have six elastase genes which encode the structurally similar proteins elastase 1, 2, 2A, 2B, 3A, and 3B. Like most of the human elastases, elastase 2A is secreted from the pancreas as a zymogen. In other species, elastase 2A has been shown to preferentially cleave proteins after leucine, methionine, and phenylalanine residues. [provided by RefSeq, May 2009]
- ENST00000359621
- ENSP00000352639
- ENSG00000142615
- ELA2A
- PE-1
- ELA2A
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
cell type or tissue | 0.61 | ||
gene perturbation | 0.6 | ||
tissue sample | 0.6 | ||
protein domain | 0.58 | ||
cell line | 0.49 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 6.75 (req: < 5)
Gene RIFs: 4 (req: <= 3)
Antibodies: 100 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 6.75 (req: >= 5)
Gene RIFs: 4 (req: > 3)
Antibodies: 100 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 5
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
Related Tools
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (41)
Nearest Tclin Targets
Pathways (5)
Reactome (3)
KEGG (2)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Developmental Biology | ||||
Reactome | Formation of the cornified envelope | ||||
Reactome | Keratinization | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Developmental Biology | ||||
Formation of the cornified envelope | ||||
Keratinization | ||||
Viral Interactions (0)
Gene Ontology Terms (9)
Functions (3)
Components (4)
Processes (2)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Direct Assay (IDA) | MGI | |||
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Traceable Author Statement (TAS) | Reactome | |||
Disease Associations ()
GWAS Traits (8)
Items per page:
1 – 5 of 8
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
urate measurement | 3 | 4 | 4 | 92.5 | |||||
1 | 5 | 0 | 1.6 | 91.3 | |||||
creatinine measurement | 4 | 4 | 4 | 84.3 | |||||
glomerular filtration rate | 4 | 4 | 4 | 80.8 | |||||
body mass index | 2 | 2 | 2 | 49.4 | |||||
Items per page:
1 – 5 of 8
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
urate measurement | 4 | 92.5 | |||||
0 | 1.6 | 91.3 | |||||
creatinine measurement | 4 | 84.3 | |||||
glomerular filtration rate | 4 | 80.8 | |||||
body mass index | 2 | 49.4 | |||||
Find similar targets by:
IDG Resources
Orthologs (6)
1 – 5 of 6
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | chymotrypsin like elastase family member 2A | VGNC:5016 | 747215 | |||||
Mouse | MGI:95316 | 13706 | ||||||
Rat | RGD:2548 | 24332 | ||||||
Horse | chymotrypsin-like elastase family member 2A | 100050670 | ||||||
Cow | chymotrypsin-like elastase family, member 2A | 282687 | ||||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | chymotrypsin like elastase family member 2A | |||||
Mouse | ||||||
Rat | ||||||
Horse | chymotrypsin-like elastase family member 2A | |||||
Cow | chymotrypsin-like elastase family, member 2A | |||||
Publication Statistics
PubMed Score 6.75
PubMed score by year
PubTator Score 18.69
PubTator score by year
Related Publications
Text Mined References (19)
GeneRif Annotations (4)
Items per page:
0 of 0
PMID | Year | Title |
|---|