CELA2A
Chymotrypsin-like elastase family member 2A
Protein Classes
Protein Summary
Acts upon elastin. Elastases form a subfamily of serine proteases that hydrolyze many proteins in addition to elastin. Humans have six elastase genes which encode the structurally similar proteins elastase 1, 2, 2A, 2B, 3A, and 3B. Like most of the human elastases, elastase 2A is secreted from the pancreas as a zymogen. In other species, elastase 2A has been shown to preferentially cleave proteins after leucine, methionine, and phenylalanine residues. [provided by RefSeq, May 2009]
- ENST00000359621
- ENSP00000352639
- ENSG00000142615
- ELA2A
- PE-1
- ELA2A
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
cell type or tissue | 0.61 | ||
gene perturbation | 0.6 | ||
tissue sample | 0.6 | ||
protein domain | 0.58 | ||
cell line | 0.49 | ||
Related Tools
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 6.75 (req: < 5)
Gene RIFs: 4 (req: <= 3)
Antibodies: 100 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 6.75 (req: >= 5)
Gene RIFs: 4 (req: > 3)
Antibodies: 100 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 5
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
GWAS Traits (8)
Items per page:
1 – 5 of 8
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
urate measurement | 3 | 4 | 4 | 92.5 | |||||
1 | 5 | 0 | 1.6 | 91.3 | |||||
creatinine measurement | 4 | 4 | 4 | 84.3 | |||||
glomerular filtration rate | 4 | 4 | 4 | 80.8 | |||||
body mass index | 2 | 2 | 2 | 49.4 | |||||
Items per page:
1 – 5 of 8
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
urate measurement | 4 | 92.5 | |||||
0 | 1.6 | 91.3 | |||||
creatinine measurement | 4 | 84.3 | |||||
glomerular filtration rate | 4 | 80.8 | |||||
body mass index | 2 | 49.4 | |||||
Orthologs (6)
1 – 5 of 6
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | chymotrypsin like elastase family member 2A | VGNC:5016 | 747215 | |||||
Mouse | MGI:95316 | 13706 | ||||||
Rat | RGD:2548 | 24332 | ||||||
Horse | chymotrypsin-like elastase family member 2A | 100050670 | ||||||
Cow | chymotrypsin-like elastase family, member 2A | 282687 | ||||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | chymotrypsin like elastase family member 2A | |||||
Mouse | ||||||
Rat | ||||||
Horse | chymotrypsin-like elastase family member 2A | |||||
Cow | chymotrypsin-like elastase family, member 2A | |||||
Protein Structure (0 Structures, 1 AlphaFold Model)
Pathways (5)
Reactome (3)
KEGG (2)
Click on a row in the table to change the structure displayed.
Items per page:
1 – 3 of 3
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Developmental Biology | ||||
Reactome | Formation of the cornified envelope | ||||
Reactome | Keratinization | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Developmental Biology | ||||
Formation of the cornified envelope | ||||
Keratinization | ||||
Gene Ontology Terms (9)
Functions (3)
Components (4)
Processes (2)
Items per page:
10
1 – 3 of 3
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Direct Assay (IDA) | MGI | |||
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Traceable Author Statement (TAS) | Reactome | |||
Protein-Protein Interactions (41)
1 – 10 of 41
CPB1
Family: Enzyme
Novelty: 0.00108031
Score: 0.945
Data Source: STRINGDB
KLK5
Family: Enzyme
Novelty: 0.00835407
Score: 0.913
Data Source: Reactome,STRINGDB
SPINK5
Family: Enzyme
Novelty: 0.00451563
Score: 0.905
Data Source: STRINGDB
DSC1
Novelty: 0.01434802
Score: 0.905
Data Source: STRINGDB
DSG2
Novelty: 0.00524156
Score: 0.902
Data Source: STRINGDB
DSG4
Novelty: 0.01599371
Score: 0.902
Data Source: STRINGDB
DSG1
Novelty: 0.00142889
Score: 0.902
Data Source: STRINGDB
DSC3
Novelty: 0.00457331
Score: 0.901
Data Source: STRINGDB
DSC2
Novelty: 0.00642576
Score: 0.901
Data Source: STRINGDB
DSP
Novelty: 0.00178018
Score: 0.9
Data Source: STRINGDB
Publication Statistics
PubMed Score 6.75
PubMed score by year
PubTator Score 18.69
PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
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