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Tbio
CELA2A
Chymotrypsin-like elastase family member 2A

Protein Summary
Description
Acts upon elastin. Elastases form a subfamily of serine proteases that hydrolyze many proteins in addition to elastin. Humans have six elastase genes which encode the structurally similar proteins elastase 1, 2, 2A, 2B, 3A, and 3B. Like most of the human elastases, elastase 2A is secreted from the pancreas as a zymogen. In other species, elastase 2A has been shown to preferentially cleave proteins after leucine, methionine, and phenylalanine residues. [provided by RefSeq, May 2009]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000359621
  • ENSP00000352639
  • ENSG00000142615

Symbol
  • ELA2A
  • PE-1
  • ELA2A
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
cell type or tissue
0.61
gene perturbation
0.6
tissue sample
0.6
protein domain
0.58
cell line
0.49


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 6.7   (req: < 5)
Gene RIFs: 4   (req: <= 3)
Antibodies: 100   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 6.7   (req: >= 5)
Gene RIFs: 4   (req: > 3)
Antibodies: 100   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
1
1
0
1.8
45
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
1.8
45
Orthologs (6)
1 – 5 of 6
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
chymotrypsin like elastase family member 2A
VGNC:5016
747215
Mouse
MGI:95316
13706
Rat
RGD:2548
24332
Horse
chymotrypsin-like elastase family member 2A
100050670
Cow
chymotrypsin-like elastase family, member 2A
282687
Species
Name
OMA
EggNOG
Inparanoid
Chimp
chymotrypsin like elastase family member 2A
Mouse
Rat
Horse
chymotrypsin-like elastase family member 2A
Cow
chymotrypsin-like elastase family, member 2A
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-P08217-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (5)
Developmental Biology (R-HSA-1266738)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Developmental Biology
Reactome
Formation of the cornified envelope
Reactome
Keratinization
Name
Explore in Pharos
Explore in Source
Developmental Biology
Formation of the cornified envelope
Keratinization
Protein-Protein Interactions (41)
1 – 10 of 41
CPB1
Tchem
Family: Enzyme
Novelty: 0.00108031
Score: 0.945
Data Source: STRINGDB
KLK5
Tchem
Family: Enzyme
Novelty: 0.00835407
Score: 0.913
Data Source: Reactome,STRINGDB
SPINK5
Tbio
Family: Enzyme
Novelty: 0.00451563
Score: 0.905
Data Source: STRINGDB
DSC1
Tbio
Novelty: 0.01434802
Score: 0.905
Data Source: STRINGDB
DSG2
Tbio
Novelty: 0.00524156
Score: 0.902
Data Source: STRINGDB
DSG4
Tbio
Novelty: 0.01599371
Score: 0.902
Data Source: STRINGDB
DSG1
Tbio
Novelty: 0.00142889
Score: 0.902
Data Source: STRINGDB
DSC3
Tbio
Novelty: 0.00457331
Score: 0.901
Data Source: STRINGDB
DSC2
Tbio
Novelty: 0.00642576
Score: 0.901
Data Source: STRINGDB
DSP
Tbio
Novelty: 0.00178018
Score: 0.9
Data Source: STRINGDB
Publication Statistics
PubMed Score  6.70

PubMed score by year
PubTator Score  18.69

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer