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Tchem
ABCB1
Multidrug resistance protein 1

Protein Summary
Description
Energy-dependent efflux pump responsible for decreased drug accumulation in multidrug-resistant cells. The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance. The protein encoded by this gene is an ATP-dependent drug efflux pump for xenobiotic compounds with broad substrate specificity. It is responsible for decreased drug accumulation in multidrug-resistant cells and often mediates the development of resistance to anticancer drugs. This protein also functions as a transporter in the blood-brain barrier. Mutations in this gene are associated with colchicine resistance and Inflammatory bowel disease 13. Alternativ ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000265724
  • ENSP00000265724
  • ENSG00000085563
  • ENST00000543898
  • ENSP00000444095
  • ENST00000622132
  • ENSP00000478255

Symbol
  • MDR1
  • PGY1
  • CLCS
  • MDR1
  • P-GP
  • PGY1
  • ABC20
  • CD243
  • GP170
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
chemical
1
drug
1
molecular function
0.99
co-expressed gene
0.98
gene perturbation
0.95


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 6875.82   (req: < 5)
Gene RIFs: 1749   (req: <= 3)
Antibodies: 1260   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 6875.82   (req: >= 5)
Gene RIFs: 1749   (req: > 3)
Antibodies: 1260   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 16
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 919
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 20
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
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GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (20)
nintedanib
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chlorpromazine
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imatinib
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aripiprazole
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haloperidol
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verapamil
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pimozide
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quinidine
Rendered image for quinidine
ketoconazole
Rendered image for ketoconazole
tamoxifen
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Active Ligands (919)
epigallocatechin gallate
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doramapimod
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Niguldipine
Rendered image for Niguldipine
US9090657, DEBIO-025, 2
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US9090657, Cyclosporine A, 1
Rendered image for US9090657, Cyclosporine A, 1
PB28
Rendered image for PB28
CHEMBL242983
Rendered image for CHEMBL242983
CEP-33779
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combretastatin A4
Rendered image for combretastatin A4
Nelfinavir
Rendered image for Nelfinavir
Protein-Protein Interactions (203)
BCL2
Tclin
Novelty:  0.00608635
p_int:  0.999999915
p_ni:  6.7e-8
p_wrong:  1.8e-8
Score:  0.179
Data Source:  BioPlex,STRINGDB
LGALS3
Tchem
Novelty:  0.00032754
p_int:  0.999904316
p_ni:  0.000095679
p_wrong:  5e-9
Score:  0.426
Data Source:  BioPlex,STRINGDB
CCR6
Tchem
Family:  GPCR
Novelty:  0.00257933
p_int:  0.997898888
p_ni:  0.001726548
p_wrong:  0.000374564
Score:  0.23
Data Source:  BioPlex,STRINGDB
TP53
Tchem
Family:  TF
Novelty:  0.00001907
Score:  0.975
Data Source:  STRINGDB
MAPK8
Tchem
Family:  Kinase
Novelty:  0.00055723
Score:  0.935
Data Source:  STRINGDB
EP300
Tchem
Family:  Epigenetic
Novelty:  0.00055009
Score:  0.915
Data Source:  STRINGDB
RPA1
Tchem
Novelty:  0.00212665
Score:  0.902
Data Source:  STRINGDB
TAF1
Tchem
Family:  Kinase
Novelty:  0.00555929
Score:  0.902
Data Source:  STRINGDB
CYP3A5
Tclin
Family:  Enzyme
Novelty:  0.00105607
Score:  0.87
Data Source:  STRINGDB
CYP3A4
Tclin
Family:  Enzyme
Novelty:  0.00015515
Score:  0.852
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (20)
ABC-family proteins mediated transport (R-HSA-382556)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 5
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
ABC-family proteins mediated transport
Reactome
Abacavir transmembrane transport
Reactome
Abacavir transport and metabolism
Reactome
Metabolism
Reactome
Transport of small molecules
Name
Explore in Pharos
Explore in Source
ABC-family proteins mediated transport
Abacavir transmembrane transport
Abacavir transport and metabolism
Metabolism
Transport of small molecules
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (22)
Find Similar Targets
Items per page:
10
1 – 7 of 7
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Direct Assay (IDA)
BHF-UCL
Traceable Author Statement (TAS)
ProtInc
Traceable Author Statement (TAS)
ProtInc
Traceable Author Statement (TAS)
ProtInc
Traceable Author Statement (TAS)
Reactome
Disease Associations (null)
No disease associations found
GWAS Traits (17)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
serum alanine aminotransferase measurement
3
3
2
13.6
91.9
1
1
0
1.2
88.6
red blood cell distribution width
3
3
3
78.2
1
2
0
1.5
71.2
low density lipoprotein cholesterol measurement
4
4
4
64.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
serum alanine aminotransferase measurement
2
13.6
91.9
0
1.2
88.6
red blood cell distribution width
3
78.2
0
1.5
71.2
low density lipoprotein cholesterol measurement
4
64.6
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (7)
1 – 5 of 7
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
ATP binding cassette subfamily B member 1
VGNC:4240
463516
Macaque
multidrug resistance protein 1 [Source:RefSeq peptide;Acc:NP_001028059]
Mouse
MGI:97570
18671
Rat
Horse
ATP binding cassette subfamily B member 1
VGNC:14907
100034074
Species
Name
OMA
EggNOG
Inparanoid
Chimp
ATP binding cassette subfamily B member 1
Macaque
multidrug resistance protein 1 [Source:RefSeq peptide;Acc:NP_001028059]
Mouse
Rat
Horse
ATP binding cassette subfamily B member 1
Publication Statistics
PubMed Score 6875.82
PubMed score by year
PubTator Score 11506.56
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title