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Tchem
ABCB1
Multidrug resistance protein 1

Protein Summary
Description
Energy-dependent efflux pump responsible for decreased drug accumulation in multidrug-resistant cells. The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance. The protein encoded by this gene is an ATP-dependent drug efflux pump for xenobiotic compounds with broad substrate specificity. It is responsible for decreased drug accumulation in multidrug-resistant cells and often mediates the development of resistance to anticancer drugs. This protein also functions as a transporter in the blood-brain barrier. Mutations in this gene are associated with colchicine resistance and Inflammatory bowel disease 13. Alternativ ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000265724
  • ENSP00000265724
  • ENSG00000085563
  • ENST00000543898
  • ENSP00000444095
  • ENST00000622132
  • ENSP00000478255

Symbol
  • MDR1
  • PGY1
  • CLCS
  • MDR1
  • P-GP
  • PGY1
  • ABC20
  • CD243
  • GP170
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
chemical
1
drug
1
molecular function
0.99
co-expressed gene
0.98
gene perturbation
0.95


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 6875.82   (req: < 5)
Gene RIFs: 2032   (req: <= 3)
Antibodies: 1260   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 6875.82   (req: >= 5)
Gene RIFs: 2032   (req: > 3)
Antibodies: 1260   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 16
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 919
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 20