Tbio CD55 Complement decay-accelerating factor

Protein Summary

Description

This protein recognizes C4b and C3b fragments that condense with cell-surface hydroxyl or amino groups when nascent C4b and C3b are locally generated during C4 and c3 activation. Interaction of daf with cell-associated C4b and C3b polypeptides interferes with their ability to catalyze the conversion of C2 and factor B to enzymatically active C2a and Bb and thereby prevents the formation of C4b2a and C3bBb, the amplification convertases of the complement cascade (PubMed:7525274). Inhibits complement activation by destabilizing and preventing the formation of C3 and C5 convertases, which prevents complement damage (PubMed:28657829). (Microbial infection) Acts as a receptor for Coxsackievirus A21, coxsackieviruses B1, B3 and B5. (Microbial infection) Acts as a receptor for Human enterovirus 70 and D68 (Probable). (Microbial infection) Acts as a receptor for Human echoviruses 6, 7, 11, 12, 20 and 21. This gene encodes a glycoprotein involved in the regulation of the complement cascade. Binding of the encoded protein to complement proteins accelerates their decay, thereby disrupting the cascade and preventing damage to host cells. Antigens present on this protein constitute the Cromer blood group system (CROM). Alternative splicing results in multiple transcript variants. The predominant transcript variant encodes a membrane-bound protein, but alternatively spliced transcripts may produce soluble proteins. [provided by RefSeq, Jul 2014]

Uniprot Accession IDs

• P08174
• B1AP14
• D3DT83
• D3DT84
• E7ER69
• P09679
• P78361
• Q14UF2
• Q14UF3
• Q14UF4
• Q14UF5
• Q14UF6

Gene Name

• CD55

Ensembl ID

• ENST00000314754
• ENSP00000316333
• ENSG00000196352
• ENST00000367064
• ENSP00000356031
• ENST00000644836
• ENSP00000495518
• ENST00000645323
• ENSP00000496251

Symbol

• CR
• DAF
• CR
• TC
• DAF
• CROM
• CHAPLE

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
virus perturbation	1
transcription factor perturbation	0.96
biological term	0.94
transcription factor binding site profile	0.91
biological process	0.89

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2181.61   (req: < 5)

Gene RIFs: 158   (req: <= 3)

Antibodies: 1444   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2181.61   (req: >= 5)

Gene RIFs: 158   (req: > 3)

Antibodies: 1444   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 14

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0