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Tbio
CD55
Complement decay-accelerating factor

Protein Summary
Description
This protein recognizes C4b and C3b fragments that condense with cell-surface hydroxyl or amino groups when nascent C4b and C3b are locally generated during C4 and c3 activation. Interaction of daf with cell-associated C4b and C3b polypeptides interferes with their ability to catalyze the conversion of C2 and factor B to enzymatically active C2a and Bb and thereby prevents the formation of C4b2a and C3bBb, the amplification convertases of the complement cascade (PubMed:7525274). Inhibits complement activation by destabilizing and preventing the formation of C3 and C5 convertases, which prevents complement damage (PubMed:28657829). (Microbial infection) Acts as a receptor for Coxsackievirus A21, coxsackieviruses B1, B3 and B5. (Microbial infection) Acts as a receptor for Human enterovirus 70 and D68 (Probable). (Microbial infection) Acts as a receptor for Human echoviruses 6, 7, 11, 12, 20 and 21. This gene encodes a glycoprotein involved in the regulation of the complement cascade. Bin ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000314754
  • ENSP00000316333
  • ENSG00000196352
  • ENST00000367064
  • ENSP00000356031
  • ENST00000644836
  • ENSP00000495518
  • ENST00000645323
  • ENSP00000496251

Symbol
  • CR
  • DAF
  • CR
  • TC
  • DAF
  • CROM
  • CHAPLE
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
virus perturbation
1
transcription factor perturbation
0.96
biological term
0.94
transcription factor binding site profile
0.91
biological process
0.89


Related Tools
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1858.4   (req: < 5)
Gene RIFs: 139   (req: <= 3)
Antibodies: 1444   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1858.4   (req: >= 5)
Gene RIFs: 139   (req: > 3)
Antibodies: 1444   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 14
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (8)
1 – 5 of 8
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
CD55 molecule
VGNC:7359
744672
Macaque
CD55 molecule (Cromer blood group)
714370
Mouse
MGI:104850
13136
Mouse
MGI:104849
13137
Rat
RGD:620651
64036
Species
Name
OMA
EggNOG
Inparanoid
Chimp
CD55 molecule
Macaque
CD55 molecule (Cromer blood group)
Mouse
Mouse
Rat
Protein Data Bank (22)
1 – 5 of 22
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (104)
Asparagine N-linked glycosylation (R-HSA-446203)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 17
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Asparagine N-linked glycosylation
Reactome
COPI-mediated anterograde transport
Reactome
Class B/2 (Secretin family receptors)
Reactome
Complement cascade
Reactome
ER to Golgi Anterograde Transport
Name
Explore in Pharos
Explore in Source
Asparagine N-linked glycosylation
COPI-mediated anterograde transport
Class B/2 (Secretin family receptors)
Complement cascade
ER to Golgi Anterograde Transport
Gene Ontology Terms (25)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Protein-Protein Interactions (191)
1 – 10 of 191
C2
Tbio
Novelty: 0.00974862
p_int: 0.999941524
p_ni: 0.000029745
p_wrong: 0.000028731
Score: 0.985
Data Source: BioPlex,Reactome,STRINGDB
HFE
Tbio
Novelty: 0.00042077
p_int: 0.999359815
p_ni: 0.000638531
p_wrong: 0.000001654
Data Source: BioPlex
LY86
Tbio
Novelty: 0.00314575
p_int: 0.998055158
p_ni: 0.001831187
p_wrong: 0.000113654
Data Source: BioPlex
PDCD2
Tbio
Novelty: 0.05054811
p_int: 0.996218308
p_ni: 0.00364198
p_wrong: 0.000139712
Data Source: BioPlex
CHI3L1
Tbio
Family: Enzyme
Novelty: 0.00119387
p_int: 0.985984372
p_ni: 0.014014916
p_wrong: 7.12e-7
Score: 0.455
Data Source: BioPlex,STRINGDB
ABCG2
Tchem
Family: Transporter
Novelty: 0.00029779
p_int: 0.948557248
p_ni: 0.050592219
p_wrong: 0.000850534
Data Source: BioPlex
C3
Tbio
Novelty: 0.00019115
Score: 0.997
Data Source: Reactome,STRINGDB
CD59
Tbio
Novelty: 0.0008352
Score: 0.991
Data Source: STRINGDB
ADGRE5
Tbio
Family: GPCR
Novelty: 0.01137558
Score: 0.99
Data Source: Reactome,STRINGDB
C4A
Tbio
Novelty: 0.00062793
Score: 0.969
Data Source: Reactome,STRINGDB
Publication Statistics
PubMed Score  1858.40

PubMed score by year
PubTator Score  736.04

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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