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Tclin
CHRM4
Muscarinic acetylcholine receptor M4

Protein Summary
Description
The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. Primary transducing effect is inhibition of adenylate cyclase. The muscarinic cholinergic receptors belong to a larger family of G protein-coupled receptors. The functional diversity of these receptors is defined by the binding of acetylcholine and includes cellular responses such as adenylate cyclase inhibition, phosphoinositide degeneration, and potassium channel mediation. Muscarinic receptors influence many effects of acetylcholine in the central and peripheral nervous system. The clinical implications of this receptor are unknown; however, mouse studies link its function to adenylyl cyclase inhibition. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000433765
  • ENSP00000409378
  • ENSG00000180720

Symbol
  • HM4
  • M4R
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
ligand (chemical)
1
drug
0.99
chemical
0.7
pathway
0.64
biological process
0.6


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 80.86   (req: < 5)
Gene RIFs: 15   (req: <= 3)
Antibodies: 181   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 80.86   (req: >= 5)
Gene RIFs: 15   (req: > 3)
Antibodies: 181   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 13
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 200
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 47
Protein Data Bank (2)
1 – 2 of 2
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (19)
Amine ligand-binding receptors (R-HSA-375280)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 8
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Amine ligand-binding receptors
Reactome
Class A/1 (Rhodopsin-like receptors)
Reactome
G alpha (i) signalling events
Reactome
GPCR downstream signalling
Reactome
GPCR ligand binding
Name
Explore in Pharos
Explore in Source
Amine ligand-binding receptors
Class A/1 (Rhodopsin-like receptors)
G alpha (i) signalling events
GPCR downstream signalling
GPCR ligand binding
Gene Ontology Terms (18)
Items per page:
10
1 – 4 of 4
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Protein-Protein Interactions (304)
1 – 10 of 304
USP24
Tbio
Family: Enzyme
Novelty: 0.02723559
p_int: 0.998965712
p_ni: 0.001034288
Data Source: BioPlex
PDS5B
Tbio
Novelty: 0.00263816
p_int: 0.998792786
p_ni: 0.001207195
p_wrong: 2e-8
Data Source: BioPlex
PPP1R15B
Tbio
Family: Enzyme
Novelty: 0.03268691
p_int: 0.994952074
p_ni: 0.005047923
p_wrong: 3e-9
Data Source: BioPlex
GSPT1
Tbio
Family: Enzyme
Novelty: 0.04456917
p_int: 0.993456205
p_ni: 0.006543795
Score: 0.179
Data Source: BioPlex,STRINGDB
PDXDC1
Tdark
Family: Enzyme
Novelty: 0.43701506
p_int: 0.991589567
p_ni: 0.008410433
Data Source: BioPlex
CAND2
Tbio
Novelty: 0.00222158
p_int: 0.988028297
p_ni: 0.011971703
Data Source: BioPlex
XPO6
Tbio
Novelty: 0.0244998
p_int: 0.985416154
p_ni: 0.014583844
p_wrong: 3e-9
Data Source: BioPlex
LPCAT3
Tbio
Family: Enzyme
Novelty: 0.00564842
p_int: 0.985244096
p_ni: 0.014755898
p_wrong: 6e-9
Data Source: BioPlex
THADA
Tbio
Novelty: 0.02734274
p_int: 0.976791012
p_ni: 0.023208988
Data Source: BioPlex
IPO9
Tbio
Novelty: 0.06055386
p_int: 0.976368084
p_ni: 0.023631916
Data Source: BioPlex
Publication Statistics
PubMed Score  80.86

PubMed score by year
PubTator Score  40.53

PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
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