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Tclin
CHRM2
Muscarinic acetylcholine receptor M2

Protein Summary
Description
The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. Primary transducing effect is adenylate cyclase inhibition. Signaling promotes phospholipase C activity, leading to the release of inositol trisphosphate (IP3); this then triggers calcium ion release into the cytosol. The muscarinic cholinergic receptors belong to a larger family of G protein-coupled receptors. The functional diversity of these receptors is defined by the binding of acetylcholine to these receptors and includes cellular responses such as adenylate cyclase inhibition, phosphoinositide degeneration, and potassium channel mediation. Muscarinic receptors influence many effects of acetylcholine in the central and peripheral nervous system. The muscarinic cholinergic receptor 2 is involved in mediation of bradycardia and a decrease in cardiac contractility. M ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000320658
  • ENSP00000319984
  • ENSG00000181072
  • ENST00000401861
  • ENSP00000384401
  • ENST00000445907
  • ENSP00000399745
  • ENST00000453373
  • ENSP00000415386

Symbol
  • HM2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
drug
1
ligand (chemical)
1
chemical
0.84
biological process
0.79
disease
0.72


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 518.02   (req: < 5)
Gene RIFs: 86   (req: <= 3)
Antibodies: 526   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 518.02   (req: >= 5)
Gene RIFs: 86   (req: > 3)
Antibodies: 526   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 19
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 603
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 46
Protein Data Bank (4)
1 – 4 of 4
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (30)
Amine ligand-binding receptors (R-HSA-375280)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 12
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Amine ligand-binding receptors
Reactome
Cargo recognition for clathrin-mediated endocytosis
Reactome
Class A/1 (Rhodopsin-like receptors)
Reactome
Clathrin-mediated endocytosis
Reactome
G alpha (i) signalling events
Name
Explore in Pharos
Explore in Source
Amine ligand-binding receptors
Cargo recognition for clathrin-mediated endocytosis
Class A/1 (Rhodopsin-like receptors)
Clathrin-mediated endocytosis
G alpha (i) signalling events
Gene Ontology Terms (33)
Items per page:
10
1 – 6 of 6
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
CAFA
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Electronic Annotation (IEA)
Ensembl
Protein-Protein Interactions (405)
1 – 10 of 405
GNG2
Tbio
Novelty: 0.08273543
Score: 0.957
Data Source: STRINGDB
TAS2R16
Tbio
Family: GPCR
Novelty: 0.03546057
Score: 0.954
Data Source: STRINGDB
GRM8
Tchem
Family: GPCR
Novelty: 0.00998475
Score: 0.954
Data Source: STRINGDB
GNB5
Tbio
Novelty: 0.01077999
Score: 0.945
Data Source: STRINGDB
TAS2R38
Tbio
Family: GPCR
Novelty: 0.00547147
Score: 0.938
Data Source: STRINGDB
GNAI1
Tbio
Novelty: 0.12575547
Score: 0.938
Data Source: STRINGDB
PDYN
Tbio
Novelty: 0.00033852
Score: 0.934
Data Source: STRINGDB
GNB1
Tbio
Novelty: 0.04716243
Score: 0.932
Data Source: STRINGDB
GRM3
Tchem
Family: GPCR
Novelty: 0.00438401
Score: 0.93
Data Source: STRINGDB
AVP
Tbio
Novelty: 0.0001163
Score: 0.928
Data Source: STRINGDB
Publication Statistics
PubMed Score  518.02

PubMed score by year
PubTator Score  280.68

PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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