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Tclin
CHRM2
Muscarinic acetylcholine receptor M2

Protein Summary
Description
The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. Primary transducing effect is adenylate cyclase inhibition. Signaling promotes phospholipase C activity, leading to the release of inositol trisphosphate (IP3); this then triggers calcium ion release into the cytosol. The muscarinic cholinergic receptors belong to a larger family of G protein-coupled receptors. The functional diversity of these receptors is defined by the binding of acetylcholine to these receptors and includes cellular responses such as adenylate cyclase inhibition, phosphoinositide degeneration, and potassium channel mediation. Muscarinic receptors influence many effects of acetylcholine in the central and peripheral nervous system. The muscarinic cholinergic receptor 2 is involved in mediation of bradycardia and a decrease in cardiac contractility. M ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000320658
  • ENSP00000319984
  • ENSG00000181072
  • ENST00000401861
  • ENSP00000384401
  • ENST00000445907
  • ENSP00000399745
  • ENST00000453373
  • ENSP00000415386

Symbol
  • HM2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
drug
1
ligand (chemical)
1
chemical
0.84
biological process
0.79
disease
0.72


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 337.86   (req: < 5)
Gene RIFs: 86   (req: <= 3)
Antibodies: 526   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 337.86   (req: >= 5)
Gene RIFs: 86   (req: > 3)
Antibodies: 526   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 19
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 603
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 46
GWAS Traits (4)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
heart rate response to recovery post exercise
5
3
5
79.9
heart rate
1
1
1
67.4
pulse pressure measurement
1
1
1
29
risk-taking behaviour
1
1
1
20.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
heart rate response to recovery post exercise
5
79.9
heart rate
1
67.4
pulse pressure measurement
1
29
risk-taking behaviour
1
20.3
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Mouse
MGI:88397
243764
Rat
RGD:620023
81645
Dog
cholinergic receptor muscarinic 2
VGNC:39232
403858
Horse
cholinergic receptor muscarinic 2 [Source:HGNC Symbol;Acc:HGNC:1951]
Cow
cholinergic receptor muscarinic 2
VGNC:27319
522170
Species
Name
OMA
EggNOG
Inparanoid
Mouse
Rat
Dog
cholinergic receptor muscarinic 2
Horse
cholinergic receptor muscarinic 2 [Source:HGNC Symbol;Acc:HGNC:1951]
Cow
cholinergic receptor muscarinic 2
Protein Structure (4 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P08172-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 4 of 4
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (30)
Amine ligand-binding receptors (R-HSA-375280)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 12
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Amine ligand-binding receptors
Reactome
Cargo recognition for clathrin-mediated endocytosis
Reactome
Class A/1 (Rhodopsin-like receptors)
Reactome
Clathrin-mediated endocytosis
Reactome
G alpha (i) signalling events
Name
Explore in Pharos
Explore in Source
Amine ligand-binding receptors
Cargo recognition for clathrin-mediated endocytosis
Class A/1 (Rhodopsin-like receptors)
Clathrin-mediated endocytosis
G alpha (i) signalling events
Gene Ontology Terms (33)
Items per page:
10
1 – 6 of 6
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
CAFA
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Electronic Annotation (IEA)
Ensembl
Protein-Protein Interactions (405)
1 – 10 of 405
GNG2
Tbio
Novelty: 0.04807242
Score: 0.957
Data Source: STRINGDB
TAS2R16
Tbio
Family: GPCR
Novelty: 0.03181719
Score: 0.954
Data Source: STRINGDB
GRM8
Tchem
Family: GPCR
Novelty: 0.00827879
Score: 0.954
Data Source: STRINGDB
GNB5
Tbio
Novelty: 0.0067714
Score: 0.945
Data Source: STRINGDB
TAS2R38
Tbio
Family: GPCR
Novelty: 0.004625
Score: 0.938
Data Source: STRINGDB
GNAI1
Tbio
Novelty: 0.0488971
Score: 0.938
Data Source: STRINGDB
PDYN
Tbio
Novelty: 0.00039564
Score: 0.934
Data Source: STRINGDB
GNB1
Tbio
Novelty: 0.02477955
Score: 0.932
Data Source: STRINGDB
GRM3
Tchem
Family: GPCR
Novelty: 0.00340947
Score: 0.93
Data Source: STRINGDB
AVP
Tbio
Novelty: 0.00016475
Score: 0.928
Data Source: STRINGDB
Publication Statistics
PubMed Score  337.86

PubMed score by year
PubTator Score  280.68

PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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