Protein Summary
Acts as a transcriptional activator (PubMed:19706761, PubMed:10806483, PubMed:19878745, PubMed:24311597, PubMed:24217340). Binds to the DNA consensus sequence 5'-GACCACCCA-3' (PubMed:2105456, PubMed:8378770, PubMed:24217340). May regulate the transcription of specific genes during normal development (PubMed:19706761). May play a role in craniofacial development and digital development, as well as development of the central nervous system and gastrointestinal tract. Mediates SHH signaling (PubMed:19706761). Plays a role in cell proliferation and differentiation via its role in SHH signaling (Probable). Isoform 2: Acts as a transcriptional activator, but activates a different set of genes than isoform 1. Activates expression of CD24, unlike isoform 1. Mediates SHH signaling. Promotes cancer cell migration. This gene encodes a member of the Kruppel family of zinc finger proteins. The encoded transcription factor is activated by the sonic hedgehog signal transduction cascade and regulates ...more
- ENST00000228682
- ENSP00000228682
- ENSG00000111087
- ENST00000528467
- ENSP00000434408
- ENST00000543426
- ENSP00000437607
- ENST00000546141
- ENSP00000441006
- GLI
- GLI
- PAPA8
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
---|---|---|---|
biological process | 0.85 | ||
molecular function | 0.79 | ||
transcription factor binding site profile | 0.76 | ||
biological term | 0.73 | ||
gene perturbation | 0.72 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 1423.99 (req: < 5)
Gene RIFs: 298 (req: <= 3)
Antibodies: 671 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 1423.99 (req: >= 5)
Gene RIFs: 298 (req: > 3)
Antibodies: 671 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 39
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligands: 4
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
Related Tools

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (4)
Protein-Protein Interactions (329)
Nearest Tclin Targets (2)
Upstream (1)
Downstream (1)
1 – 1 of 1
Pathways (41)
Reactome (6)
KEGG (4)
PathwayCommons (8)
WikiPathways (23)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|---|
Reactome | Degradation of GLI1 by the proteasome | ||||
Reactome | GLI proteins bind promoters of Hh responsive genes to promote transcription | ||||
Reactome | Hedgehog 'off' state | ||||
Reactome | Hedgehog 'on' state | ||||
Reactome | Signal Transduction | ||||
Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|
Degradation of GLI1 by the proteasome | ||||
GLI proteins bind promoters of Hh responsive genes to promote transcription | ||||
Hedgehog 'off' state | ||||
Hedgehog 'on' state | ||||
Signal Transduction | ||||
Viral Interactions (0)
Gene Ontology Terms (46)
Functions (10)
Components (7)
Processes (29)
GO Term | Evidence | Assigned by | ||
---|---|---|---|---|
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Direct Assay (IDA) | MGI | |||
Inferred from Direct Assay (IDA) | MGI | |||
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Sequence Alignment (ISA) | NTNU_SB | |||
Inferred from Electronic Annotation (IEA) | UniProtKB-KW | |||
Inferred from Electronic Annotation (IEA) | Ensembl | |||
Inferred from Electronic Annotation (IEA) | Ensembl | |||
Inferred from Electronic Annotation (IEA) | Ensembl | |||
Disease Associations ()
GWAS Traits (24)
Items per page:
1 – 5 of 24
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|---|---|
urate measurement | 6 | 4 | 6 | 5.2 | 98 | ||||
high density lipoprotein cholesterol measurement | 8 | 7 | 17 | 97.3 | |||||
triglyceride measurement | 8 | 7 | 14 | 2.7 | 96.2 | ||||
glomerular filtration rate | 3 | 2 | 3 | 89 | |||||
apolipoprotein A 1 measurement | 2 | 2 | 2 | 84.9 | |||||
Items per page:
1 – 5 of 24
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|
urate measurement | 6 | 5.2 | 98 | ||||
high density lipoprotein cholesterol measurement | 17 | 97.3 | |||||
triglyceride measurement | 14 | 2.7 | 96.2 | ||||
glomerular filtration rate | 3 | 89 | |||||
apolipoprotein A 1 measurement | 2 | 84.9 | |||||
Find similar targets by:
IDG Resources
Orthologs (9)
1 – 5 of 9
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|---|---|
Chimp | GLI family zinc finger 1 | VGNC:8955 | 100615503 | |||||
Macaque | GLI family zinc finger 1 | 714843 | ||||||
Mouse | MGI:95727 | 14632 | ||||||
Rat | RGD:621673 | 140589 | ||||||
Dog | GLI family zinc finger 1 | VGNC:41256 | 481126 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|
Chimp | GLI family zinc finger 1 | |||||
Macaque | GLI family zinc finger 1 | |||||
Mouse | ||||||
Rat | ||||||
Dog | GLI family zinc finger 1 | |||||
Publication Statistics
PubMed Score 1423.99
PubMed score by year
PubTator Score 909.12
PubTator score by year
Related Publications
Text Mined References (332)
GeneRif Annotations (298)
Items per page:
0 of 0
PMID | Year | Title |
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