Tchem GLI1 Zinc finger protein GLI1

Protein Summary

Description

Acts as a transcriptional activator (PubMed:19706761, PubMed:10806483, PubMed:19878745, PubMed:24311597, PubMed:24217340). Binds to the DNA consensus sequence 5'-GACCACCCA-3' (PubMed:2105456, PubMed:8378770, PubMed:24217340). May regulate the transcription of specific genes during normal development (PubMed:19706761). May play a role in craniofacial development and digital development, as well as development of the central nervous system and gastrointestinal tract. Mediates SHH signaling (PubMed:19706761). Plays a role in cell proliferation and differentiation via its role in SHH signaling (Probable). Isoform 2: Acts as a transcriptional activator, but activates a different set of genes than isoform 1. Activates expression of CD24, unlike isoform 1. Mediates SHH signaling. Promotes cancer cell migration. This gene encodes a member of the Kruppel family of zinc finger proteins. The encoded transcription factor is activated by the sonic hedgehog signal transduction cascade and regulates stem cell proliferation. The activity and nuclear localization of this protein is negatively regulated by p53 in an inhibitory loop. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2009]

Uniprot Accession IDs

• P08151
• D0EUY3
• E9PQQ9
• F5H6H8
• Q8TDN9

Gene Name

• GLI1

Ensembl ID

• ENST00000228682
• ENSP00000228682
• ENSG00000111087
• ENST00000528467
• ENSP00000434408
• ENST00000543426
• ENSP00000437607
• ENST00000546141
• ENSP00000441006

Symbol

• GLI
• GLI
• PAPA8

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
biological process	0.85
molecular function	0.79
transcription factor binding site profile	0.76
biological term	0.73
gene perturbation	0.72

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1566.81   (req: < 5)

Gene RIFs: 392   (req: <= 3)

Antibodies: 671   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1566.81   (req: >= 5)

Gene RIFs: 392   (req: > 3)

Antibodies: 671   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 39

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 4

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0