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Tchem
GLI1
Zinc finger protein GLI1

Protein Summary
Description
Acts as a transcriptional activator (PubMed:19706761, PubMed:10806483, PubMed:19878745, PubMed:24311597, PubMed:24217340). Binds to the DNA consensus sequence 5'-GACCACCCA-3' (PubMed:2105456, PubMed:8378770, PubMed:24217340). May regulate the transcription of specific genes during normal development (PubMed:19706761). May play a role in craniofacial development and digital development, as well as development of the central nervous system and gastrointestinal tract. Mediates SHH signaling (PubMed:19706761). Plays a role in cell proliferation and differentiation via its role in SHH signaling (Probable). Isoform 2: Acts as a transcriptional activator, but activates a different set of genes than isoform 1. Activates expression of CD24, unlike isoform 1. Mediates SHH signaling. Promotes cancer cell migration. This gene encodes a member of the Kruppel family of zinc finger proteins. The encoded transcription factor is activated by the sonic hedgehog signal transduction cascade and regulates ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000228682
  • ENSP00000228682
  • ENSG00000111087
  • ENST00000528467
  • ENSP00000434408
  • ENST00000543426
  • ENSP00000437607
  • ENST00000546141
  • ENSP00000441006

Symbol
  • GLI
  • GLI
  • PAPA8
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0.85
molecular function
0.79
transcription factor binding site profile
0.76
biological term
0.73
gene perturbation
0.72


Related Tools
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1372.81   (req: < 5)
Gene RIFs: 298   (req: <= 3)
Antibodies: 671   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1372.81   (req: >= 5)
Gene RIFs: 298   (req: > 3)
Antibodies: 671   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 39
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 2
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
GLI family zinc finger 1
VGNC:8955
100615503
Macaque
GLI family zinc finger 1
714843
Mouse
MGI:95727
14632
Rat
RGD:621673
140589
Dog
GLI family zinc finger 1
VGNC:41256
481126
Species
Name
OMA
EggNOG
Inparanoid
Chimp
GLI family zinc finger 1
Macaque
GLI family zinc finger 1
Mouse
Rat
Dog
GLI family zinc finger 1
Protein Structure (4 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P08151-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 4 of 4
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (41)
Degradation of GLI1 by the proteasome (R-HSA-5610780)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 6
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Degradation of GLI1 by the proteasome
Reactome
GLI proteins bind promoters of Hh responsive genes to promote transcription
Reactome
Hedgehog 'off' state
Reactome
Hedgehog 'on' state
Reactome
Signal Transduction
Name
Explore in Pharos
Explore in Source
Degradation of GLI1 by the proteasome
GLI proteins bind promoters of Hh responsive genes to promote transcription
Hedgehog 'off' state
Hedgehog 'on' state
Signal Transduction
Gene Ontology Terms (46)
Items per page:
10
1 – 10 of 10
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
MGI
Inferred from Direct Assay (IDA)
MGI
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Sequence Alignment (ISA)
NTNU_SB
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Protein-Protein Interactions (329)
1 – 10 of 329
SUFU
Tbio
Novelty: 0.00475249
Score: 0.999
Data Source: Reactome,STRINGDB
PTCH1
Tbio
Novelty: 0.00077635
Score: 0.995
Data Source: STRINGDB
STK36
Tbio
Family: Kinase
Novelty: 0.0963277
Score: 0.992
Data Source: STRINGDB
SMO
Tclin
Family: GPCR
Novelty: 0.03235855
Score: 0.99
Data Source: STRINGDB
ULK3
Tchem
Family: Kinase
Novelty: 0.0783598
Score: 0.989
Data Source: Reactome,STRINGDB
PTCH2
Tbio
Novelty: 0.00927849
Score: 0.982
Data Source: STRINGDB
SHH
Tchem
Novelty: 0.00028347
Score: 0.978
Data Source: STRINGDB
BTRC
Tbio
Novelty: 0.00293475
Score: 0.971
Data Source: STRINGDB
HHIP
Tbio
Novelty: 0.00982404
Score: 0.97
Data Source: STRINGDB
SPOP
Tbio
Novelty: 0.00663363
Score: 0.967
Data Source: STRINGDB
Publication Statistics
PubMed Score  1372.81

PubMed score by year
PubTator Score  909.12

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer