You are using an outdated browser. Please upgrade your browser to improve your experience.

Tchem
GLI1
Zinc finger protein GLI1

Protein Summary
Description
Acts as a transcriptional activator (PubMed:19706761, PubMed:10806483, PubMed:19878745, PubMed:24311597, PubMed:24217340). Binds to the DNA consensus sequence 5'-GACCACCCA-3' (PubMed:2105456, PubMed:8378770, PubMed:24217340). May regulate the transcription of specific genes during normal development (PubMed:19706761). May play a role in craniofacial development and digital development, as well as development of the central nervous system and gastrointestinal tract. Mediates SHH signaling (PubMed:19706761). Plays a role in cell proliferation and differentiation via its role in SHH signaling (Probable). Isoform 2: Acts as a transcriptional activator, but activates a different set of genes than isoform 1. Activates expression of CD24, unlike isoform 1. Mediates SHH signaling. Promotes cancer cell migration. This gene encodes a member of the Kruppel family of zinc finger proteins. The encoded transcription factor is activated by the sonic hedgehog signal transduction cascade and regulates ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000228682
  • ENSP00000228682
  • ENSG00000111087
  • ENST00000528467
  • ENSP00000434408
  • ENST00000543426
  • ENSP00000437607
  • ENST00000546141
  • ENSP00000441006

Symbol
  • GLI
  • GLI
  • PAPA8
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0.85
molecular function
0.79
transcription factor binding site profile
0.76
biological term
0.73
gene perturbation
0.72


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1069.93   (req: < 5)
Gene RIFs: 298   (req: <= 3)
Antibodies: 671   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1069.93   (req: >= 5)
Gene RIFs: 298   (req: > 3)
Antibodies: 671   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 39
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 2
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Data Bank (4)
1 – 4 of 4
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (41)
Degradation of GLI1 by the proteasome (R-HSA-5610780)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 6
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Degradation of GLI1 by the proteasome
Reactome
GLI proteins bind promoters of Hh responsive genes to promote transcription
Reactome
Hedgehog 'off' state
Reactome
Hedgehog 'on' state
Reactome
Signal Transduction
Name
Explore in Pharos
Explore in Source
Degradation of GLI1 by the proteasome
GLI proteins bind promoters of Hh responsive genes to promote transcription
Hedgehog 'off' state
Hedgehog 'on' state
Signal Transduction
Gene Ontology Terms (46)
Items per page:
10
1 – 10 of 10
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
MGI
Inferred from Direct Assay (IDA)
MGI
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Sequence Alignment (ISA)
NTNU_SB
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Protein-Protein Interactions (329)
1 – 10 of 329
SUFU
Tbio
Novelty: 0.00485324
Score: 0.999
Data Source: Reactome,STRINGDB
PTCH1
Tbio
Novelty: 0.00096312
Score: 0.995
Data Source: STRINGDB
STK36
Tdark
Family: Kinase
Novelty: 0.30550841
Score: 0.992
Data Source: STRINGDB
SMO
Tclin
Family: GPCR
Novelty: 0.04792829
Score: 0.99
Data Source: STRINGDB
ULK3
Tchem
Family: Kinase
Novelty: 0.11123566
Score: 0.989
Data Source: Reactome,STRINGDB
PTCH2
Tbio
Novelty: 0.01422381
Score: 0.982
Data Source: STRINGDB
SHH
Tchem
Novelty: 0.00033539
Score: 0.978
Data Source: STRINGDB
BTRC
Tbio
Novelty: 0.00393331
Score: 0.971
Data Source: STRINGDB
HHIP
Tbio
Novelty: 0.01371119
Score: 0.97
Data Source: STRINGDB
SPOP
Tbio
Novelty: 0.00958399
Score: 0.967
Data Source: STRINGDB
Publication Statistics
PubMed Score  1069.93

PubMed score by year
PubTator Score  909.12

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer