Tchem GLI1 Zinc finger protein GLI1

Protein Summary

Description

Acts as a transcriptional activator (PubMed:19706761, PubMed:10806483, PubMed:19878745, PubMed:24311597, PubMed:24217340). Binds to the DNA consensus sequence 5'-GACCACCCA-3' (PubMed:2105456, PubMed:8378770, PubMed:24217340). May regulate the transcription of specific genes during normal development (PubMed:19706761). May play a role in craniofacial development and digital development, as well as development of the central nervous system and gastrointestinal tract. Mediates SHH signaling (PubMed:19706761). Plays a role in cell proliferation and differentiation via its role in SHH signaling (Probable). Isoform 2: Acts as a transcriptional activator, but activates a different set of genes than isoform 1. Activates expression of CD24, unlike isoform 1. Mediates SHH signaling. Promotes cancer cell migration. This gene encodes a member of the Kruppel family of zinc finger proteins. The encoded transcription factor is activated by the sonic hedgehog signal transduction cascade and regulates stem cell proliferation. The activity and nuclear localization of this protein is negatively regulated by p53 in an inhibitory loop. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2009]

Uniprot Accession IDs

• P08151
• D0EUY3
• E9PQQ9
• F5H6H8
• Q8TDN9

Gene Name

• GLI1

Ensembl ID

• ENST00000228682
• ENSP00000228682
• ENSG00000111087
• ENST00000528467
• ENSP00000434408
• ENST00000543426
• ENSP00000437607
• ENST00000546141
• ENSP00000441006

Symbol

• GLI
• GLI
• PAPA8

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
biological process	0.85
molecular function	0.79
transcription factor binding site profile	0.76
biological term	0.73
gene perturbation	0.72

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1069.93   (req: < 5)

Gene RIFs: 298   (req: <= 3)

Antibodies: 671   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1069.93   (req: >= 5)

Gene RIFs: 298   (req: > 3)

Antibodies: 671   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 39

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 2

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Active Ligands (2)

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1 – 2 of 2

CHEMBL1215434

GLI1Tchem TF

IC50: 6.18

CHEMBL504404

GLI1Tchem TF

IC50: 6.21

Protein Data Bank (4)

1 – 4 of 4

PDB Structure Id	Ligand	Method	Resolution (Å)	M.W. (kDa)	Pub Year	Title

PDB Structure Id	M.W.	Resolution	Pub Year

Pathways (41)

Reactome (6)

KEGG (4)

PathwayCommons (8)

WikiPathways (23)

Degradation of GLI1 by the proteasome (R-HSA-5610780)

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Data Source	Name	Explore in Pharos	Explore in Source
Reactome	Degradation of GLI1 by the proteasome	61 targets	R-HSA-5610780
Reactome	GLI proteins bind promoters of Hh responsive genes to promote transcription	7 targets	R-HSA-5635851
Reactome	Hedgehog 'off' state	104 targets	R-HSA-5610787
Reactome	Hedgehog 'on' state	87 targets	R-HSA-5632684
Reactome	Signal Transduction	2704 targets	R-HSA-162582

Name	Explore in Pharos	Explore in Source
Degradation of GLI1 by the proteasome	61 targets	R-HSA-5610780
GLI proteins bind promoters of Hh responsive genes to promote transcription	7 targets	R-HSA-5635851
Hedgehog 'off' state	104 targets	R-HSA-5610787
Hedgehog 'on' state	87 targets	R-HSA-5632684
Signal Transduction	2704 targets	R-HSA-162582

Gene Ontology Terms (46)

Functions (10)

Components (7)

Processes (29)

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10

1 – 10 of 10

GO Term	Evidence	Assigned by
chromatin binding	Inferred from Direct Assay (IDA)	UniProtKB
DNA binding	Inferred from Direct Assay (IDA)	MGI
RNA polymerase II regulatory region sequence-specific DNA binding	Inferred from Direct Assay (IDA)	MGI
sequence-specific DNA binding	Inferred from Direct Assay (IDA)	UniProtKB
transcription regulatory region DNA binding	Inferred from Direct Assay (IDA)	UniProtKB
DNA-binding transcription factor activity, RNA polymerase II-specific	Inferred from Sequence Alignment (ISA)	NTNU_SB
metal ion binding	Inferred from Electronic Annotation (IEA)	UniProtKB-KW
microtubule binding	Inferred from Electronic Annotation (IEA)	Ensembl
RNA polymerase II proximal promoter sequence-specific DNA binding	Inferred from Electronic Annotation (IEA)	Ensembl
transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding	Inferred from Electronic Annotation (IEA)	Ensembl

Protein-Protein Interactions (329)

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1 – 10 of 329

• See Interactions on String-DB

SUFU

Tbio

Novelty: 0.00485324

Score: 0.999

Data Source: Reactome,STRINGDB

PTCH1

Tbio

Novelty: 0.00096312

Score: 0.995

Data Source: STRINGDB

STK36

Tdark

Family: Kinase

Novelty: 0.30550841

Score: 0.992

Data Source: STRINGDB

SMO

Tclin

Family: GPCR

Novelty: 0.04792829

Score: 0.99

Data Source: STRINGDB

ULK3

Tchem

Family: Kinase

Novelty: 0.11123566

Score: 0.989

Data Source: Reactome,STRINGDB

PTCH2

Tbio

Novelty: 0.01422381

Score: 0.982

Data Source: STRINGDB

SHH

Tchem

Novelty: 0.00033539

Score: 0.978

Data Source: STRINGDB

BTRC

Tbio

Novelty: 0.00393331

Score: 0.971

Data Source: STRINGDB

HHIP

Tbio

Novelty: 0.01371119

Score: 0.97

Data Source: STRINGDB

SPOP

Tbio

Novelty: 0.00958399

Score: 0.967

Data Source: STRINGDB

Publication Statistics

PubMed Score  1069.93

PubMed score by year

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PubTator Score  909.12

PubTator score by year

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Amino Acid Sequence

Residue Counts

Protein Sequence

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3D-structure
Acetylation
Activator
Alternative splicing
Complete proteome
Cytoplasm
Developmental protein
Differentiation
DNA-binding
Isopeptide bond