Tchem GLI1 Zinc finger protein GLI1

Protein Summary

Description

Acts as a transcriptional activator (PubMed:19706761, PubMed:10806483, PubMed:19878745, PubMed:24311597, PubMed:24217340). Binds to the DNA consensus sequence 5'-GACCACCCA-3' (PubMed:2105456, PubMed:8378770, PubMed:24217340). May regulate the transcription of specific genes during normal development (PubMed:19706761). May play a role in craniofacial development and digital development, as well as development of the central nervous system and gastrointestinal tract. Mediates SHH signaling (PubMed:19706761). Plays a role in cell proliferation and differentiation via its role in SHH signaling (Probable). Isoform 2: Acts as a transcriptional activator, but activates a different set of genes than isoform 1. Activates expression of CD24, unlike isoform 1. Mediates SHH signaling. Promotes cancer cell migration. This gene encodes a member of the Kruppel family of zinc finger proteins. The encoded transcription factor is activated by the sonic hedgehog signal transduction cascade and regulates stem cell proliferation. The activity and nuclear localization of this protein is negatively regulated by p53 in an inhibitory loop. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2009]

Uniprot Accession IDs

• P08151
• D0EUY3
• E9PQQ9
• F5H6H8
• Q8TDN9

Gene Name

• GLI1

Ensembl ID

• ENST00000228682
• ENSP00000228682
• ENSG00000111087
• ENST00000528467
• ENSP00000434408
• ENST00000543426
• ENSP00000437607
• ENST00000546141
• ENSP00000441006

Symbol

• GLI
• GLI
• PAPA8

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
biological process	0.85
molecular function	0.79
transcription factor binding site profile	0.76
biological term	0.73
gene perturbation	0.72

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1423.99   (req: < 5)

Gene RIFs: 298   (req: <= 3)

Antibodies: 671   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1423.99   (req: >= 5)

Gene RIFs: 298   (req: > 3)

Antibodies: 671   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 39

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 4

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Protein Sequence and Structure

Residue Counts

Protein Sequence

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Expression Data (0 Tissues)

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No expression data found

Related Tools

Target Illumination GWAS Analytics (TIGA)

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

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GENEVA

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

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GlyGen

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

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ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

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Approved Drugs (0)

No approved drugs found

Active Ligands (4)

Explore Active Ligands

1 – 4 of 4

Physalin B

GLI1Tchem TF

pIC50 : 6.21

CHEMBL4205868

GLI1Tchem TF

pIC50 : 6.19

Physalin F

GLI1Tchem TF

pIC50 : 6.18

CHEMBL4214812

GLI1Tchem TF

pIC50 : 6.13

Protein-Protein Interactions (329)

Explore Interacting Targets

1 – 10 of 329

• See Interactions on String-DB

SUFU

Tbio

Novelty:  0.00475249

Score:  0.999

Data Source:  Reactome,STRINGDB

PTCH1

Tbio

Novelty:  0.00077635

Score:  0.995

Data Source:  STRINGDB

STK36

Tbio

Family:  Kinase

Novelty:  0.0963277

Score:  0.992

Data Source:  STRINGDB

SMO

Tclin

Family:  GPCR

Novelty:  0.03235855

Score:  0.99

Data Source:  STRINGDB

ULK3

Tchem

Family:  Kinase

Novelty:  0.0783598

Score:  0.989

Data Source:  Reactome,STRINGDB

PTCH2

Tbio

Novelty:  0.00927849

Score:  0.982

Data Source:  STRINGDB

SHH

Tchem

Novelty:  0.00028347

Score:  0.978

Data Source:  STRINGDB

BTRC

Tbio

Novelty:  0.00293475

Score:  0.971

Data Source:  STRINGDB

HHIP

Tbio

Novelty:  0.00982404

Score:  0.97

Data Source:  STRINGDB

SPOP

Tbio

Novelty:  0.00663363

Score:  0.967

Data Source:  STRINGDB

Nearest Tclin Targets (2)

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Upstream (1)

Downstream (1)

1 – 1 of 1

GSK3B

Tclin

Family:  Kinase

KEGG Distance:  1

Common Pathways:  3

1: Basal cell carcinoma

2: Pathways in cancer

3: Hedgehog signaling pathway

Pathways (41)

Reactome (6)

KEGG (4)

PathwayCommons (8)

WikiPathways (23)

Degradation of GLI1 by the proteasome (R-HSA-5610780)

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Data Source	Name	Explore in Pharos	Explore in Source
Reactome	Degradation of GLI1 by the proteasome	61 targets	R-HSA-5610780
Reactome	GLI proteins bind promoters of Hh responsive genes to promote transcription	7 targets	R-HSA-5635851
Reactome	Hedgehog 'off' state	104 targets	R-HSA-5610787
Reactome	Hedgehog 'on' state	87 targets	R-HSA-5632684
Reactome	Signal Transduction	2704 targets	R-HSA-162582

Name	Explore in Pharos	Explore in Source
Degradation of GLI1 by the proteasome	61 targets	R-HSA-5610780
GLI proteins bind promoters of Hh responsive genes to promote transcription	7 targets	R-HSA-5635851
Hedgehog 'off' state	104 targets	R-HSA-5610787
Hedgehog 'on' state	87 targets	R-HSA-5632684
Signal Transduction	2704 targets	R-HSA-162582

Viral Interactions (0)

No viral interactions found

Gene Ontology Terms (46)

Functions (10)

Components (7)

Processes (29)

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1 – 10 of 10

GO Term	Evidence	Assigned by
chromatin binding	Inferred from Direct Assay (IDA)	UniProtKB
DNA binding	Inferred from Direct Assay (IDA)	MGI
RNA polymerase II regulatory region sequence-specific DNA binding	Inferred from Direct Assay (IDA)	MGI
sequence-specific DNA binding	Inferred from Direct Assay (IDA)	UniProtKB
transcription regulatory region DNA binding	Inferred from Direct Assay (IDA)	UniProtKB
DNA-binding transcription factor activity, RNA polymerase II-specific	Inferred from Sequence Alignment (ISA)	NTNU_SB
metal ion binding	Inferred from Electronic Annotation (IEA)	UniProtKB-KW
microtubule binding	Inferred from Electronic Annotation (IEA)	Ensembl
RNA polymerase II proximal promoter sequence-specific DNA binding	Inferred from Electronic Annotation (IEA)	Ensembl
transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding	Inferred from Electronic Annotation (IEA)	Ensembl

Disease Associations ()

No disease associations found

GWAS Traits (24)

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1 – 5 of 24

GWAS Trait	EFO ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
urate measurement	EFO_0004531	6	4	6	5.2	98
high density lipoprotein cholesterol measurement	EFO_0004612	8	7	17		97.3
triglyceride measurement	EFO_0004530	8	7	14	2.7	96.2
glomerular filtration rate	EFO_0005208	3	2	3		89
apolipoprotein A 1 measurement	EFO_0004614	2	2	2		84.9

• Explore on Target Illumination GWAS Analytics (TIGA)

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GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
urate measurement	EFO_0004531	6	5.2	98
high density lipoprotein cholesterol measurement	EFO_0004612	17		97.3
triglyceride measurement	EFO_0004530	14	2.7	96.2
glomerular filtration rate	EFO_0005208	3		89
apolipoprotein A 1 measurement	EFO_0004614	2		84.9

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Find similar targets by:

UniProt Keyword Find Similar Targets

No Header	No Header
3D-structure
Acetylation
Activator
Alternative splicing
Complete proteome
Cytoplasm
Developmental protein
Differentiation
DNA-binding
Isopeptide bond

GWAS Trait Find Similar Targets

No Header	No Header
apolipoprotein A 1 measurement
apolipoprotein B measurement
aspartate aminotransferase measurement
blood urea nitrogen measurement
coronary artery disease
creatinine measurement
follistatin measurement
glomerular filtration rate
glucose measurement
hematocrit

IDG Resources

No IDG generated resources found

Orthologs (9)

1 – 5 of 9

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Chimp	GLI family zinc finger 1	VGNC:8955	100615503
Macaque	GLI family zinc finger 1		714843
Mouse	GLI-Kruppel family member GLI1	MGI:95727	14632
Rat	GLI family zinc finger 1	RGD:621673	140589
Dog	GLI family zinc finger 1	VGNC:41256	481126

Species	Name	OMA	EggNOG	Inparanoid
Chimp	GLI family zinc finger 1
Macaque	GLI family zinc finger 1
Mouse	GLI-Kruppel family member GLI1
Rat	GLI family zinc finger 1
Dog	GLI family zinc finger 1

Publication Statistics

PubMed Score 1423.99

PubMed score by year

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PubTator Score 909.12

PubTator score by year

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Related Publications

Text Mined References (332)

GeneRif Annotations (298)

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PMID	Year	Title