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Tbio
ANXA6
Annexin A6

Protein Summary
Description
May associate with CD21. May regulate the release of Ca(2+) from intracellular stores. Annexin VI belongs to a family of calcium-dependent membrane and phospholipid binding proteins. Several members of the annexin family have been implicated in membrane-related events along exocytotic and endocytotic pathways. The annexin VI gene is approximately 60 kbp long and contains 26 exons. It encodes a protein of about 68 kDa that consists of eight 68-amino acid repeats separated by linking sequences of variable lengths. It is highly similar to human annexins I and II sequences, each of which contain four such repeats. Annexin VI has been implicated in mediating the endosome aggregation and vesicle fusion in secreting epithelia during exocytosis. Alternatively spliced transcript variants have been described. [provided by RefSeq, Aug 2010]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000354546
  • ENSP00000346550
  • ENSG00000197043
  • ENST00000523714
  • ENSP00000430517

Symbol
  • ANX6
  • p68
  • p70
  • ANX6
  • CBP68
  • CPB-II
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
1
disease perturbation
0.98
interacting protein
0.98
cellular component
0.92
kinase perturbation
0.91


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 364.1   (req: < 5)
Gene RIFs: 46   (req: <= 3)
Antibodies: 478   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 364.1   (req: >= 5)
Gene RIFs: 46   (req: > 3)
Antibodies: 478   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 26
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (61)
ATP6V0A2
Tbio
Family:  Enzyme
Novelty:  0.00504614
p_int:  0.905598168
p_ni:  0.094401832
Score:  0.22
Data Source:  BioPlex,STRINGDB
DYSF
Tbio
Novelty:  0.00248634
Score:  0.975
Data Source:  Reactome,STRINGDB
TRIM72
Tbio
Novelty:  0.01480557
Score:  0.954
Data Source:  Reactome,STRINGDB
CAV3
Tbio
Novelty:  0.00190092
Score:  0.929
Data Source:  Reactome,STRINGDB
ANXA1
Tbio
Novelty:  0.00103537
Score:  0.91
Data Source:  Reactome,STRINGDB
ANXA2
Tbio
Novelty:  0.00103362
Score:  0.908
Data Source:  Reactome,STRINGDB
S100A1
Tbio
Novelty:  0.00309618
Score:  0.717
Data Source:  STRINGDB
NDST1
Tbio
Family:  Enzyme
Novelty:  0.00955868
Score:  0.717
Data Source:  STRINGDB
S100A11
Tbio
Novelty:  0.00670943
Score:  0.707
Data Source:  STRINGDB
CD9
Tbio
Novelty:  0.00095308
Score:  0.707
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (28)
Muscle contraction (R-HSA-397014)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 2 of 2
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Muscle contraction
Reactome
Smooth Muscle Contraction
Name
Explore in Pharos
Explore in Source
Muscle contraction
Smooth Muscle Contraction
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (35)
Find Similar Targets
Items per page:
10
1 – 10 of 16
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
AgBase
Inferred from Mutant Phenotype (IMP)
UniProtKB
Inferred from Mutant Phenotype (IMP)
UniProtKB
Inferred from Mutant Phenotype (IMP)
UniProtKB
Inferred from Mutant Phenotype (IMP)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Disease Associations ()
No disease associations found
GWAS Traits (27)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
9
5
0
1.3
97.1
4
2
0
1.4
92.1
lymphocyte count
2
3
4
88.1
psoriasis vulgaris
2
1
0
1.8
81.9
red blood cell distribution width
2
1
2
81.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
1.3
97.1
0
1.4
92.1
lymphocyte count
4
88.1
psoriasis vulgaris
0
1.8
81.9
red blood cell distribution width
2
81.7
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
annexin A6
711612
Mouse
MGI:88255
11749
Rat
RGD:621172
79125
Dog
annexin A6
VGNC:37943
479325
Horse
annexin A6
VGNC:15365
100071569
Species
Name
OMA
EggNOG
Inparanoid
Macaque
annexin A6
Mouse
Rat
Dog
annexin A6
Horse
annexin A6
Publication Statistics
PubMed Score 364.10
PubMed score by year
PubTator Score 191.37
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title