Protein Summary
May associate with CD21. May regulate the release of Ca(2+) from intracellular stores. Annexin VI belongs to a family of calcium-dependent membrane and phospholipid binding proteins. Several members of the annexin family have been implicated in membrane-related events along exocytotic and endocytotic pathways. The annexin VI gene is approximately 60 kbp long and contains 26 exons. It encodes a protein of about 68 kDa that consists of eight 68-amino acid repeats separated by linking sequences of variable lengths. It is highly similar to human annexins I and II sequences, each of which contain four such repeats. Annexin VI has been implicated in mediating the endosome aggregation and vesicle fusion in secreting epithelia during exocytosis. Alternatively spliced transcript variants have been described. [provided by RefSeq, Aug 2010]
- ENST00000354546
- ENSP00000346550
- ENSG00000197043
- ENST00000523714
- ENSP00000430517
- ANX6
- p68
- p70
- ANX6
- CBP68
- CPB-II
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
molecular function | 1 | ||
disease perturbation | 0.98 | ||
interacting protein | 0.98 | ||
cellular component | 0.92 | ||
kinase perturbation | 0.91 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 393.79 (req: < 5)
Gene RIFs: 61 (req: <= 3)
Antibodies: 478 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 393.79 (req: >= 5)
Gene RIFs: 61 (req: > 3)
Antibodies: 478 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 26
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0