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Tbio
ANXA6
Annexin A6

Protein Summary
Description
May associate with CD21. May regulate the release of Ca(2+) from intracellular stores. Annexin VI belongs to a family of calcium-dependent membrane and phospholipid binding proteins. Several members of the annexin family have been implicated in membrane-related events along exocytotic and endocytotic pathways. The annexin VI gene is approximately 60 kbp long and contains 26 exons. It encodes a protein of about 68 kDa that consists of eight 68-amino acid repeats separated by linking sequences of variable lengths. It is highly similar to human annexins I and II sequences, each of which contain four such repeats. Annexin VI has been implicated in mediating the endosome aggregation and vesicle fusion in secreting epithelia during exocytosis. Alternatively spliced transcript variants have been described. [provided by RefSeq, Aug 2010]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000354546
  • ENSP00000346550
  • ENSG00000197043
  • ENST00000523714
  • ENSP00000430517

Symbol
  • ANX6
  • p68
  • p70
  • ANX6
  • CBP68
  • CPB-II
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
1
disease perturbation
0.98
interacting protein
0.98
cellular component
0.92
kinase perturbation
0.91


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 358.27   (req: < 5)
Gene RIFs: 46   (req: <= 3)
Antibodies: 478   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 358.27   (req: >= 5)
Gene RIFs: 46   (req: > 3)
Antibodies: 478   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 26
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
lymphocyte count
2
1
2
73.9
monocyte count
1
1
1
39.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
lymphocyte count
2
73.9
monocyte count
1
39.6
Protein Data Bank (1)
1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (28)
Muscle contraction (R-HSA-397014)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 2 of 2
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Muscle contraction
Reactome
Smooth Muscle Contraction
Name
Explore in Pharos
Explore in Source
Muscle contraction
Smooth Muscle Contraction
Gene Ontology Terms (35)
Items per page:
10
1 – 10 of 16
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
AgBase
Inferred from Mutant Phenotype (IMP)
UniProtKB
Inferred from Mutant Phenotype (IMP)
UniProtKB
Inferred from Mutant Phenotype (IMP)
UniProtKB
Inferred from Mutant Phenotype (IMP)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Protein-Protein Interactions (61)
1 – 10 of 61
ATP6V0A2
Tbio
Family: Enzyme
Novelty: 0.00504614
p_int: 0.905598168
p_ni: 0.094401832
Score: 0.22
Data Source: BioPlex,STRINGDB
DYSF
Tbio
Novelty: 0.00248634
Score: 0.975
Data Source: Reactome,STRINGDB
TRIM72
Tbio
Novelty: 0.01480557
Score: 0.954
Data Source: Reactome,STRINGDB
CAV3
Tbio
Novelty: 0.00190092
Score: 0.929
Data Source: Reactome,STRINGDB
ANXA1
Tbio
Novelty: 0.00103537
Score: 0.91
Data Source: Reactome,STRINGDB
ANXA2
Tbio
Novelty: 0.00103362
Score: 0.908
Data Source: Reactome,STRINGDB
S100A1
Tbio
Novelty: 0.00309618
Score: 0.717
Data Source: STRINGDB
NDST1
Tbio
Family: Enzyme
Novelty: 0.00955868
Score: 0.717
Data Source: STRINGDB
S100A11
Tbio
Novelty: 0.00670943
Score: 0.707
Data Source: STRINGDB
CD9
Tbio
Novelty: 0.00095308
Score: 0.707
Data Source: STRINGDB
Publication Statistics
PubMed Score  358.27

PubMed score by year
PubTator Score  191.37

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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