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Tbio
COL1A2
Collagen alpha-2(I) chain

Protein Summary
Description
Type I collagen is a member of group I collagen (fibrillar forming collagen). This gene encodes the pro-alpha2 chain of type I collagen whose triple helix comprises two alpha1 chains and one alpha2 chain. Type I is a fibril-forming collagen found in most connective tissues and is abundant in bone, cornea, dermis and tendon. Mutations in this gene are associated with osteogenesis imperfecta types I-IV, Ehlers-Danlos syndrome type VIIB, recessive Ehlers-Danlos syndrome Classical type, idiopathic osteoporosis, and atypical Marfan syndrome. Symptoms associated with mutations in this gene, however, tend to be less severe than mutations in the gene for the alpha1 chain of type I collagen (COL1A1) reflecting the different role of alpha2 chains in matrix integrity. Three transcripts, resulting from the use of alternate polyadenylation signals, have been identified for this gene. [provided by R. Dalgleish, Feb 2008]
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor perturbation
0.99
biological term
0.93
disease perturbation
0.93
disease
0.91
kinase perturbation
0.88


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ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1890.61   (req: < 5)
Gene RIFs: 167   (req: <= 3)
Antibodies: 368   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1890.61   (req: >= 5)
Gene RIFs: 167   (req: > 3)
Antibodies: 368   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 24
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
appendicular lean mass
2
1
2
77.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
appendicular lean mass
2
77.2
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
collagen type I alpha 2 chain
VGNC:10658
455117
Mouse
MGI:88468
12843
Rat
RGD:621351
84352
Dog
collagen type I alpha 2 chain
VGNC:39465
403824
Horse
collagen type I alpha 2 chain
VGNC:16731
100051715
Species
Name
OMA
EggNOG
Inparanoid
Chimp
collagen type I alpha 2 chain
Mouse
Rat
Dog
collagen type I alpha 2 chain
Horse
collagen type I alpha 2 chain
Protein Data Bank (3)
1 – 3 of 3
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (42)
Assembly of collagen fibrils and other multimeric structures (R-HSA-2022090)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 12
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Assembly of collagen fibrils and other multimeric structures
Reactome
Binding and Uptake of Ligands by Scavenger Receptors
Reactome
Collagen biosynthesis and modifying enzymes
Reactome
Collagen chain trimerization
Reactome
Collagen formation
Name
Explore in Pharos
Explore in Source
Assembly of collagen fibrils and other multimeric structures
Binding and Uptake of Ligands by Scavenger Receptors
Collagen biosynthesis and modifying enzymes
Collagen chain trimerization
Collagen formation
Gene Ontology Terms (32)
Items per page:
10
1 – 8 of 8
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
MGI
Inferred from Physical Interaction (IPI)
CAFA
Inferred from Mutant Phenotype (IMP)
UniProtKB
Inferred from High Throughput Direct Assay (HDA)
BHF-UCL
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
Ensembl
Protein-Protein Interactions (256)
1 – 10 of 256
ERAL1
Tbio
Family: Enzyme
Novelty: 0.01695998
p_int: 0.99999197
p_ni: 4.06e-7
p_wrong: 0.000007624
Score: 0.309
Data Source: BioPlex,STRINGDB
CAMKMT
Tbio
Family: Enzyme
Novelty: 0.00382649
p_int: 0.999966698
p_ni: 3.37e-7
p_wrong: 0.000032965
Score: 0.309
Data Source: BioPlex,STRINGDB
YAF2
Tbio
Novelty: 0.10772286
p_int: 0.785516837
p_ni: 0.000073813
p_wrong: 0.21440935
Score: 0.181
Data Source: BioPlex,STRINGDB
TIMM44
Tbio
Family: Enzyme
Novelty: 0.020862
p_int: 0.761560642
p_ni: 0.000018537
p_wrong: 0.238420821
Score: 0.379
Data Source: BioPlex,STRINGDB
COL1A1
Tbio
Novelty: 0.00063584
Score: 0.999
Data Source: Reactome,STRINGDB
COL5A2
Tbio
Novelty: 0.01352973
Score: 0.996
Data Source: STRINGDB
COL3A1
Tbio
Novelty: 0.00197327
Score: 0.995
Data Source: STRINGDB
LUM
Tbio
Novelty: 0.00219939
Score: 0.995
Data Source: STRINGDB
SPARC
Tbio
Novelty: 0.00063267
Score: 0.992
Data Source: STRINGDB
COL6A1
Tbio
Novelty: 0.00644855
Score: 0.989
Data Source: STRINGDB
Publication Statistics
PubMed Score  1890.61

PubMed score by year
PubTator Score  1270.01

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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