Tbio RHO Rhodopsin

Protein Summary

Description

Photoreceptor required for image-forming vision at low light intensity (PubMed:8107847, PubMed:7846071). Required for photoreceptor cell viability after birth (PubMed:2215617, PubMed:12566452). Light-induced isomerization of the chromophore 11-cis-retinal to all-trans-retinal triggers a conformational change that activates signaling via G-proteins (PubMed:8107847, PubMed:28524165, PubMed:26200343, PubMed:28753425). Subsequent receptor phosphorylation mediates displacement of the bound G-protein alpha subunit by the arrestin SAG and terminates signaling (PubMed:28524165, PubMed:26200343). The protein encoded by this gene is found in rod cells in the back of the eye and is essential for vision in low-light conditions. The encoded protein binds to 11-cis retinal and is activated when light hits the retinal molecule. Defects in this gene are a cause of congenital stationary night blindness. [provided by RefSeq, Aug 2017]

Uniprot Accession IDs

• P08100
• Q16414
• Q2M249

Gene Name

• RHO

Ensembl ID

• ENST00000296271
• ENSP00000296271
• ENSG00000163914

Symbol

• OPN2
• RP4
• OPN2
• CSNBAD1

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
protein domain	0.85
gene perturbation	0.79
cell type or tissue	0.74
molecular function	0.73
biological term	0.72

Protein Classes

PANTHER Classes

Protein / Receptor / G-protein Coupled Receptor / Rhodopsin

DTO Classes

Protein / G-protein Coupled Receptor / Class A Rhodopsin Like / Rhodopsin

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 8140.12   (req: < 5)

Gene RIFs: 149   (req: <= 3)

Antibodies: 492   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 8140.12   (req: >= 5)

Gene RIFs: 149   (req: > 3)

Antibodies: 492   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 17

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0