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Tbio
RHO
Rhodopsin

Protein Summary
Description
Photoreceptor required for image-forming vision at low light intensity (PubMed:8107847, PubMed:7846071). Required for photoreceptor cell viability after birth (PubMed:2215617, PubMed:12566452). Light-induced isomerization of the chromophore 11-cis-retinal to all-trans-retinal triggers a conformational change that activates signaling via G-proteins (PubMed:8107847, PubMed:28524165, PubMed:26200343, PubMed:28753425). Subsequent receptor phosphorylation mediates displacement of the bound G-protein alpha subunit by the arrestin SAG and terminates signaling (PubMed:28524165, PubMed:26200343). The protein encoded by this gene is found in rod cells in the back of the eye and is essential for vision in low-light conditions. The encoded protein binds to 11-cis retinal and is activated when light hits the retinal molecule. Defects in this gene are a cause of congenital stationary night blindness. [provided by RefSeq, Aug 2017]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000296271
  • ENSP00000296271
  • ENSG00000163914

Symbol
  • OPN2
  • RP4
  • OPN2
  • CSNBAD1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.85
gene perturbation
0.79
cell type or tissue
0.74
molecular function
0.73
biological term
0.72


Related Tools
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ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 7662.03   (req: < 5)
Gene RIFs: 127   (req: <= 3)
Antibodies: 492   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 7662.03   (req: >= 5)
Gene RIFs: 127   (req: > 3)
Antibodies: 492   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 17
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
rhodopsin
VGNC:2537
460685
Mouse
MGI:97914
212541
Rat
RGD:3573
24717
Dog
rhodopsin
VGNC:45554
493763
Horse
rhodopsin
VGNC:22370
100056641
Species
Name
OMA
EggNOG
Inparanoid
Chimp
rhodopsin
Mouse
Rat
Dog
rhodopsin
Horse
rhodopsin
Protein Structure (4 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P08100-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 4 of 4
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (23)
Activation of the phototransduction cascade (R-HSA-2485179)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 16
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Activation of the phototransduction cascade
Reactome
Cargo trafficking to the periciliary membrane
Reactome
Cilium Assembly
Reactome
Class A/1 (Rhodopsin-like receptors)
Reactome
G alpha (i) signalling events
Name
Explore in Pharos
Explore in Source
Activation of the phototransduction cascade
Cargo trafficking to the periciliary membrane
Cilium Assembly
Class A/1 (Rhodopsin-like receptors)
G alpha (i) signalling events
Protein-Protein Interactions (293)
1 – 10 of 293
SAG
Tbio
Novelty: 0.00040944
Score: 0.999
Data Source: Reactome,STRINGDB
GRK1
Tchem
Family: Kinase
Novelty: 0.00598725
Score: 0.999
Data Source: Reactome,STRINGDB
GNB1
Tbio
Novelty: 0.02477955
Score: 0.996
Data Source: Reactome,STRINGDB
GRK7
Tchem
Family: Kinase
Novelty: 0.01119521
Score: 0.996
Data Source: Reactome,STRINGDB
RCVRN
Tbio
Novelty: 0.00266222
Score: 0.991
Data Source: STRINGDB
GNAT1
Tbio
Novelty: 0.03042002
Score: 0.991
Data Source: Reactome,STRINGDB
GNAT2
Tbio
Novelty: 0.01683655
Score: 0.99
Data Source: Reactome,STRINGDB
GNG2
Tbio
Novelty: 0.04807242
Score: 0.988
Data Source: Reactome,STRINGDB
GNB3
Tbio
Novelty: 0.0037117
Score: 0.978
Data Source: STRINGDB
ARF4
Tbio
Family: Enzyme
Novelty: 0.01166211
Score: 0.976
Data Source: Reactome,STRINGDB
Publication Statistics
PubMed Score  7662.03

PubMed score by year
PubTator Score  3931.88

PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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